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significant decrease » significant increase (Expand Search), significantly increased (Expand Search)
significant results » significant reductions (Expand Search), significant reduction (Expand Search)
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17021
Table_1_Oxidative stress and inflammation mediate the association between elevated oxidative balance scores and improved sleep quality: evidence from NHANES.docx
Published 2024“…Sensitivity analyses revealed a significant association between OBS and sleep disorder (p < 0.001).…”
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17022
Table 4_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.xlsx
Published 2025“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”
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17023
Table 1_Long-term multicomponent exercise enhances functional mobility in early-stage Parkinson’s disease: a 48-month retrospective cohort study.docx
Published 2025“…Minimal detectable change (MDC), effect sizes, and linear regressions were computed.</p>Results<p>After 48 months, TUG time decreased by −3.8 s (95% CI: −5.0 to −2.6; p < 0.001; dz = −1.12) and 6MWT distance increased by +88.8 m (95% CI: 45.1 to 133.0; p < 0.001; dz = 0.72), both exceeding MDC thresholds. …”
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17024
Impact of COVID-19 on early intervention referrals (Zellner et al., 2025)
Published 2025“…Using Bayesian-interrupted time series segmented regression analysis, we then examined the impact of the pandemic on EI at three key timepoints: April 2020, September 2020, and September 2021.</p><p dir="ltr"><b>Results: </b>Overall, we found large decreases in service provision rates for the first 2 timepoints; however, by September 2021, rates had moved closer to expected prepandemic levels. …”
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17025
Supplementary file 1_Exploration of the renoprotective effect of Yi-Shen-Hua-Shi granules on db/db mice and the mechanism of podocyte apoptosis based on the GRP78/CHOP signaling pa...
Published 2025“…The expression levels of GRP78, PERK, p-PERK, CHOP, Bcl-2, Bax, and Nephrin proteins and mRNAs in mouse kidney tissues and MPC-5 cells were evaluated by immunohistochemistry, Western blotting, and real-time PCR.</p>Results<p>YSHS significantly improved the general status of db/db mice, with a significant reduction in body mass, renal function indices, total cholesterol, triglycerides, and low-density lipoprotein. …”
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17026
Data Sheet 1_EURAD state-of-the-art report: thermo-hydro-mechanical behaviour of clay buffers at high temperatures.pdf
Published 2025“…The clay mineralogy was significantly preserved. The slight changes observed in the other properties were opposite depending on the heating conditions: in the case of evaporation, the cation exchange capacity, specific surface area, sorption coefficients, and sometimes swelling pressure decreased. …”
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17027
Data Sheet 1_The role of oxidative stress in modulating mortality risk across the hypertension control cascade.docx
Published 2025“…Q1, HR: 0.82; 95% CI: 0.66–0.87; P < 0.001). A significant interaction was observed between OBS and hypertension control status (P for interaction = 0.017 and 0.026), corroborated by sensitivity analyses (P for interaction = 0.025). …”
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17028
Table 2_Strategies to support the mental health and well-being of health and care workforce: a rapid review of reviews.docx
Published 2025“…Health and care workforce report significantly greater levels of job-related burnout and mental health problems, which in turn are associated with poorer patient outcomes, increased medical errors, diminished quality and safety, decreased patient satisfaction, and reduced healthcare efficiency.…”
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17029
Data Sheet 4_CD44 knockdown alters miRNA expression and their target genes in colon cancer.pdf
Published 2025“…Introduction<p>Metastasis formation poses a significant challenge to oncologists, as it severely limits the survival of colorectal cancer (CRC) patients. …”
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17030
Table 1_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.docx
Published 2025“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”
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17031
Data Sheet 1_The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects.pdf
Published 2025“…Additionally, multiple linear regression was utilized to investigate the associations between this variant and glycemic-related quantitative traits and lipid levels.</p>Results<p>While no association was observed between the rs724030 variant in MTNR1B and prediabetes risk in the overall cohort (P > 0.05), we found the G allele of this variant was associated with higher fasting and 30-minute plasma glucose levels, decreased Insulinogenic Index (IGI), and oral disposition index (DIo) (P = 0.009, 0.001, 0.001, and 0.007, respectively) in the normal glucose tolerance (NGT) individuals with normal BMI levels. …”
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17032
Table 2_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf
Published 2025“…</p>Conclusions<p>While significant progress has been made in reducing the global burden of pediatric IE, major geographic and socio-demographic inequalities persist. …”
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17033
Image1_Association between vitamin C intake and thyroid function among U.S. adults: a population-based study.tiff
Published 2024“…Additionally, restricted cubic spline (RCS) regression was employed to assess any nonlinear relationship that may exist between vitamin C intake and thyroid function.</p>Results<p>After adjusting for covariates, our research found a significant inverse correlation between vitamin C intake and total thyroxine (TT4) (β= -0.182, P= 0.006). …”
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17034
Data Sheet 1_From court to community: a cost–benefit evaluation of a community sports programme for Arab women in Israel's multiethnic context.docx
Published 2025“…The economic evaluation incorporated reductions in healthcare utilization and medication costs, productivity gains, and QALY improvements, accounting for direct and opportunity costs.</p>Results<p>Mamanet participation was associated with improvements in physical health outcomes, including a significant reduction in psychosomatic symptoms (p < 0.001, effect size = 0.75). …”
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17035
Table 1_Strategies to support the mental health and well-being of health and care workforce: a rapid review of reviews.docx
Published 2025“…Health and care workforce report significantly greater levels of job-related burnout and mental health problems, which in turn are associated with poorer patient outcomes, increased medical errors, diminished quality and safety, decreased patient satisfaction, and reduced healthcare efficiency.…”
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17036
Image 1_The advanced lung cancer inflammation index as a predictor of kidney stone risk in men: a cross-sectional analysis.tif
Published 2025“…Background<p>Kidney stone incidence and recurrence are increasing, which poses significant health problems. The Advanced Lung Cancer Inflammation Index (ALI) combines body mass index (BMI), albumin, and neutrophil-to-lymphocyte ratio (NLR). …”
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17037
Data Sheet 1_CARTOON-based educational intervention for children to foster hygiene knowledge and emotional resilience in preschool children: a randomized controlled trial.pdf
Published 2025“…Additionally, anxiety scores significantly decreased in the intervention group post-intervention compared to baseline (2.2 ± 1.7 vs. 5.6 ± 2.5; p = .01). …”
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17038
Table 1_Nicotine dependence is associated with an increased risk of developing chronic, non-communicable inflammatory disease: a large-scale retrospective cohort study.docx
Published 2025“…Introduction<p>Chronic, non-communicable inflammatory diseases (CIDs) affect a large portion of the population, imposing a significant morbidity, encompassing a substantial mortality. …”
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17039
Table 13_Identification and validation for biomarkers associated with mitochondrial metabolism in chronic obstructive pulmonary disease.xlsx
Published 2025“…The mRNA and protein expression of APRT and LCAT were significantly decreased in COPD patients’ lung tissues.…”
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17040
Image 2_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.tif
Published 2025“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”