Data Sheet 3_Divergent trends and regional disparities in PM2.5 and O3 health economic burdens in China, 2013–2023: an integrated assessment with policy implications.zip by Ziqi Tang (10904159)

“…With 0 and 15 μg/m³ taken as the reference concentrations, all-cause mortality decreased by 47.41% (233,173 cases) and 65.55% (240,448 cases), respectively. …”

Data Sheet 1_Impact of early enteral nutrition on the prognosis of mechanically ventilated patients with chronic obstructive pulmonary disease: a retrospective cohort study based o... by Lamei Ouyang (20555782)

“…</p>Conclusion<p>Although early EN did not significantly improve overall mortality, it effectively decreased ventilation duration and hospital stays and demonstrated potential survival benefits for patients with better oxygenation. …”

Table1_Use of non-specific immunoglobulins in Catalonia in three third-level hospitals: a descriptive analysis of a hospital-prescribed medication registry.DOCX by J. Riera-Arnau (20431328)

“…In the sensitivity analysis, the A-level usage rate decreased to one-third and the B-level usage rate increased by 2–3 times. …”

Supplementary file 1_Comparison of morrow procedure and transapical beating-heart septal myectomy in patients with hypertrophic obstructive cardiomyopathy: a systematic review and... by Maxat Zhakayev (22445197)

“…Random-effects meta-analysis and meta-regression were performed.</p>Results<p>Both procedures achieved substantial and comparable reductions in LVOTG, with no significant between-group difference (p = 0.75). …”

Data Sheet 1_An analysis of the global burden of childhood and adolescent asthma attributable to high BMI: 1990–2021.pdf by Xinhui Zhang (1624039)

“…The percentage of DALYs attributable to risk factors is reported among all age groups and individuals under 20 years.</p>Results<p>From 1990 to 2021, globally, the mortality rates and numbers of asthma cases caused by high body mass index (BMI) decreased, while the numbers and rates of disability-adjusted life years (DALYs) increased. …”

Data Sheet 3_Factors influencing, and associated with, physical activity patterns in dogs with osteoarthritis-associated pain.pdf by Christina Stevens (9737867)

“…Data were analyzed using FLM and a custom R package to evaluate the effect of each factor on 24-h patterns of physical activity.</p>Results<p>At times of peak activity within a 24-h period, dogs with hindlimb OA pain, higher age, higher Clinical Metrology Instrument scores, higher joint pain, greater Body Condition Score and greater muscle atrophy all had decreased activity profiles. …”

Table1_Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway.XLSX by Sisi Lei (10999575)

“…The specific mechanism of CSP was explored using the LXRα agonist T0901317.</p>Results<p>The MS-related IR model exhibited a decreased p-Akt/Akt ratio and increased fasting glucose, insulin, homeostatic model assessment of IR, and hepatic lipid metabolism factors. …”

Data Sheet 1_Prognostic model construction and immune microenvironment analysis of pyroptosis-related genes in hepatocellular carcinoma based on single-cell RNA sequencing.zip by Haoming Shen (3816988)

“…Although pyroptosis plays a critical role in tumor-immune interactions, its prognostic significance in HCC at single-cell resolution has not been systematically investigated.…”

Image 5_Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activa... by Jiaochen Luan (9704384)

“…Multi-omics analysis revealed significant enrichment in lipid metabolic pathways, with Fasn identified as a hub gene. …”

Table 8_Identification and validation for biomarkers associated with mitochondrial metabolism in chronic obstructive pulmonary disease.xlsx by Wenjun Wang (314231)

“…The mRNA and protein expression of APRT and LCAT were significantly decreased in COPD patients’ lung tissues.…”

Data Sheet 1_Global burden of varicella and herpes zoster across 204 countries, 1990–2021: a temporal trend analysis in the era of the COVID-19 pandemic and projections to 2036.pdf... by Zilun Wu (18696883)

“…Mortality and DALYs declined significantly, with age-standardized mortality rates (ASMR) and DALYs rates (ASDR) decreasing by 50.0 and 36.3%, respectively. …”

Data Sheet 1_Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through a... by Jiaochen Luan (9704384)

“…Multi-omics analysis revealed significant enrichment in lipid metabolic pathways, with Fasn identified as a hub gene. …”

Region-scale decline in streamflow across New South Wales catchments by Danlu Guo (12549226)

“…Nearly all (104) catchments have decreasing trends in annual flow, with 32 of these being statistically significant, indicating an overall drying pattern. …”

Enhancement of mechanical and thermal properties of porous alkaline cements using silica and alumina nanoparticles by Nuno Cristelo (20594563)

“…Al nanoparticles did not enhance mechanical performance, but led to density reduction, resulting in decreased strength. Thermal conductivity showed no significant variations due to nanoparticles, with all formulations classified as T2 thermal mortars. …”

Supplementary Material for: Successful Management of Post-Thymectomy Pure Red Cell Aplasia with Rituximab: A Case Report by Abdulgayoom M. (17726475)

“…Initial treatment with prednisolone showed minimal improvement, leading to the inclusion of rituximab. This combination resulted in a significant increase in reticulocyte counts and transfusion independence. …”

The effect of cognitive behavioral therapy-based psychoeducation on substance abuse proclivity in adolescent smokers by Behiye Dilmen Bayar (19133390)

“…</p> <p>The study is an experimental study model with pretest–posttest control group. As a result of the power analysis carried out for the sample of the study, the sample size was calculated to be 110 adolescent smokers at a significance level of 0.05, confidence interval of 95%, an effect size of 0.7, and power of population representation of 0.95. …”

Table 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.xlsx by Fumiya Ito (14833366)

“…GRHL2 was upregulated in ER cells, and its knockdown and knockout significantly reduced erlotinib resistance. Further analysis revealed that GRHL2 upregulates the receptor tyrosine kinase HER3, and that HER3 knockdown similarly decreases the IC₅₀ for erlotinib. …”

Data Sheet 1_GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.pdf by Fumiya Ito (14833366)

“…GRHL2 was upregulated in ER cells, and its knockdown and knockout significantly reduced erlotinib resistance. Further analysis revealed that GRHL2 upregulates the receptor tyrosine kinase HER3, and that HER3 knockdown similarly decreases the IC₅₀ for erlotinib. …”

Image 2_A comprehensive study of hip dislocation: global health burden from 1990 to 2021 and its predictions to 2030.pdf by Xu Zheng (296676)

“…Bayesian Age-Period-Cohort models, implemented through the BAPC R package, were used to project changes in the disease burden of hip dislocation by 2030.</p>Results<p>From 1990 to 2021, the incidence rate and YLDs rate of hip dislocation decreased, while the number of cases and YLDs number increased. …”

Data Sheet 1_Analysis of pharmacotherapeutic approaches for multiple myeloma and correlated renal and pulmonary impairments: a retrospective real-world registry study in the Greate... by Ayman Alhejazi (21092054)

“…Background<p>Multiple myeloma (MM) is a plasma cell malignancy with significant unmet medical needs, particularly in the treatment of relapsed and refractory disease. …”