DataSheet1_Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut–kidney axis.PDF by Hongmei Yu (584700)

“…Comparative analyses of the gut microbiota, serum metabolites, and kidney transcriptomics before and after drug administration were performed.</p>Results<p>After treatment with HKC, EB, and their combination for 4 weeks, the urinary albumin-to-creatinine ratios decreased significantly in the db/db mice with DN. …”

Table 1_Growth regulation mechanism of Rhododendron moulmainense to high-temperature stress: integrated physiological, transcriptomic, and metabolomic insights.xlsx by Zaid Khan (625790)

“…Scanning electron microscopy resulted in reduced leaf stomatal traits, altering gas exchange, and thus, photosynthetic rates were decreased. …”

Table 5_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.xlsx by Mangle Chen (20639051)

“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”

Table 6_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.xlsx by Mangle Chen (20639051)

“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”

Supplementary Figures for AJP-Integr Reg Comp Physiol R-00035-2025R1 by Joshua Huot (20868279)

“…<i>In vivo</i>, carcass, heart, and fat mass were significantly reduced in the tumor-bearing mice. Skeletal muscle growth was impeded in the GL261 hosts, along with smaller muscle CSA. …”

Table 1_Effects of selenium-mediated RUNX2 overexpression and its transcriptome alterations on Chondrocyte injury in Kashin Beck disease.docx by Di Zhang (197959)

“…A chondrocyte injury model was established under Se-deficient conditions, while a RUNX2 overexpression model was generated by lentiviral transfection and further analyzed by RNA sequencing.</p>Results<p>The proportion of RUNX2-positive cells in KBD cartilage was significantly higher than in controls. …”

<b>Association between myristic acid in plasma triglycerides and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes: A comprehensive analysis... by Shigero Hosoe (21735020)

“…After comprehensive diabetes treatment for 2 weeks, FA levels in many TGs significantly decreased; especially, FA 14:0 levels in TGs decreased notably, and this reduction was more pronounced in patients with MASLD.…”

Table 1_Early identification of sarcopenia in patients with diabetes mellitus combined with osteoporosis: development and validation of a gender-specific nomogram.docx by Mingzhong Yu (21215879)

“…Furthermore, a sex-specific nomogram was constructed based on these indicators to predict the occurrence of sarcopenia, and the predictive efficacy and clinical value of the model were evaluated by receiver operating characteristic curve and decision curve analysis.</p>Results<p>The prevalence of sarcopenia in patients with T2DM combined with osteoporosis was 33.88%, with men having a significantly higher prevalence than women. …”

Table 3_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.xls by Mangle Chen (20639051)

“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”

Table 2_Mechanism of Huaiqihuang (HQH) against cyclophosphamide (CYP)-induced hippocampal neurotoxicity based on network pharmacology, molecular docking and experimental verificati... by Yueming Zhang (790755)

“…Experimental validation using Western blot confirmed that HQH significantly decreased the protein expression of TNF, HSP90AA1, TP53, and MAPK1 in hippocampal tissues.…”

Image 1_Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broile... by Yang Li (7082)

“…LPS and PLP + LPS group were intraperitoneally injected with LPS on days 14, 16, 18, and 20. The results demonstrated that LPS significantly decreased average daily gain (ADG), average daily feed intake (ADFI), and total antioxidant capacity (T-AOC) activity in serum and duodenum. …”

Data Sheet 2_Comprehensive analysis of SQOR involvement in ferroptosis resistance of pancreatic ductal adenocarcinoma in hypoxic environments.docx by Quan Lin (5958)

“…SQOR promotes the malignant progression of PDAC in hypoxic environment by enhancing the resistance of tumor cells to ferroptosis. SQOR knockdown resulted in decreased cell viability, decreased migration ability and increased MDA level under hypoxic Ersatin induced conditions. …”

Image 1_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.jpeg by Mangle Chen (20639051)

“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”

Table 2_Profiling of small RNAs derived from tomato brown rugose fruit virus in infected Solanum lycopersicum plants by deep sequencing.xls by Mangle Chen (20639051)

“…Seven potential target genes were selected for qRT-PCR analysis, confirming that their transcript accumulation significantly decreased in the leaves of tomato plants infected with ToBRFV. …”

Table 4_Mechanism of Huaiqihuang (HQH) against cyclophosphamide (CYP)-induced hippocampal neurotoxicity based on network pharmacology, molecular docking and experimental verificati... by Yueming Zhang (790755)

“…Experimental validation using Western blot confirmed that HQH significantly decreased the protein expression of TNF, HSP90AA1, TP53, and MAPK1 in hippocampal tissues.…”

Supplementary Material for: Efficacy of Spray Cryotherapy on Airway Secretions in Canine Models of Chronic Bronchitis and Mechanism Insights by Wang B. (4026758)

“…SCT treatment reduced mucus and pulmonary resistance, improved bronchial structure, and decreased goblet cells. SCT significantly reduced BALF mucin, MUC5AC, MUC5B, acetylcholine, IL-6, INF-γ, TNF-α, and IL-10, and bronchial MUC5AC and CHRM3. …”

Chronic hyperpolarization of dFB^23E10Ո^84C10 neurons promotes sleep and impairs sleep homeostasis. by Joseph D. Jones (13883524)

“…Two-tailed Mann–Whitney U tests revealed that sleep rebound is significantly decreased at all time points between controls and <i>dFB-Split>UAS-Kir2.1</i> female flies. …”

Table 1_Nitrite exposure on gills of Oreochromis niloticus: structure change, immune response, and apoptosis.xlsx by Chaowei Song (20639240)

“…Nitrite exposure significantly elevated serum catalase (CAT) activity and decreased superoxide dismutase (SOD) activity. …”

Construction and in vitro activity evaluation of protein transduction domain-transactivator of transcription and <i>Candida antarctica</i> lipase B fusion proteins by Xinhua Fu (20714497)

“…As the concentration of the fusion protein decreased, the effect on cell viability decreased. …”

Image1_In-situ analysis of polymetallic nodules from the clarion-Clipperton zone, Pacific Ocean: implication for controlling on chemical composition variability.jpeg by Jie Li (15030)

“…<p>Polymetallic ferromanganese nodules (PMNs) in the Clarion-Clipperton Zone (CCZ) exhibit significant spatial variability in chemical composition, which complicates exploration efforts and increases associated costs. …”