Image 1_3KO-NSCs ameliorate behavioral deficits and modulate gut microbiota in a VPA-induced C57BL/6 mouse model of autism.tif حسب Caixia Wu (8959697)

"…Assessments included behavioral assays (social interaction, repetitive behaviors), hippocampal cytokine profiling (IL-6, TNF-α), 16S rRNA sequencing for gut microbiota analysis, immunohistochemistry (Iba1⁺ microglia), and ultrastructural synaptic analysis.</p>Results<p>3KO-hiPSC-NSC treatment significantly ameliorated VPA-induced ASD-like behaviors. …"

Image 7_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.tif حسب Chen Wang (88408)

"…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…"

Table 1_Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study.docx حسب Tingwen Wang (3927815)

"…Clinical data and serum amino acid concentrations were analyzed to: (1) compare preoperative and postoperative amino acid profiles; (2) evaluate amino acid differences between groups at various timepoints and correlate with alopecia severity; (3) perform logistic regression to identify alopecia risk factors.</p>Results<p>Among 67 patients analyzed, LSG significantly decreased serum concentrations of arginine, alanine, threonine, glutamic acid, branched-chain amino acids (valine, isoleucine, leucine), and aromatic amino acids (tyrosine, phenylalanine, tryptophan) (p < 0.05), while serine and glycine increased (p < 0.05). …"

YOLOv8n-BWG model structure diagram. حسب Yaojun Zhang (389482)

"…GSConv employs a channel grouping approach, streamlining model parameters without sacrificing accuracy. Results on a specialized dataset reveal that YOLOv8n-BWG outperforms YOLOv8n by increasing the mean Average Precision (mAP) by 4.2%, boosting recognition speed by 21.3% per second, and decreasing both the number of floating-point operations (FLOPs) by 28.9% and model size by 26.3%. …"

Image 2_Low-frequency electroacupuncture attenuates methamphetamine-induced depressive-like behaviors and cognitive impairment via modulating neuroinflammation.tif حسب Jingyi Zhang (741111)

"…EA was applied at different frequencies to the Zusanli (ST36) acupoint for 7 days post-METH administration.</p>Results<p>Behavioral tests revealed that low-frequency EA significantly alleviated depressive-like behaviors and cognitive impairment. …"

Image 1_PCP4 inhibits the progression of prostate cancer through Ca2+/CAMKK2/AMPK/AR pathway.jpeg حسب Wenqiao Jia (12356306)

"…A series of molecular and biochemical experiments were carried out in PCa cell lines to investigate the mechanism underlying PCP4-mediated tumor suppression.</p>Results<p>(1) PCP4 gene loss occurs at high frequency in PCa patients, and decreased expression of PCP4 correlates with poor prognosis of PCa, particularly CRPC development; (2) TMPRSS2-ERG fusion frequently co-occurs with PCP4 deletion; (3) PCP4 suppresses prostate cancer progression in vitro and in vivo; (4) PCP4 is an androgen receptor (AR) suppressed gene; (5) PCP4 was involved in the stabilization of CAMKK2 protein; (6) PCP4 inhibits PCa progression by regulating Ca²⁺/CAMKK2/AMPK/AR signaling axis.…"

Supplementary file 1_Integrated transcriptomic analysis of COVID-19 stages and recovery: insights into key gene signatures, immune features, and diagnostic biomarkers through machi... حسب Zhiyuan Gong (51844)

"…Recovery analysis showed significantly reduced adaptive immune cells at 1 month, with partial recovery by 3 and 6 months. …"

Image 6_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg حسب Chen Wang (88408)

"…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…"

Raw data WB.pdf حسب Grazia Serino (21164993)

"…Moreover, miR-369-3p significantly decreased the release of pro-inflammatory cytokine IL-8. …"

Image 2_GPER1 signaling restricts macrophage proliferation and accumulation in human hepatocellular carcinoma.tif حسب Yanyan Yang (412382)

"…The expression of G protein–coupled estrogen receptor 1 (GPER1), a non-classical estrogen receptor, was significantly decreased in proliferating macrophages, and was inversely correlated with macrophage proliferation in HCC tumors. …"

Supplementary file 1_IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema.d... حسب Zekuan Xue (21398444)

"…The therapeutic efficacy of combined transplantation of MSCs and LEPCs was shown to be superior to that of transplantation of LEPCs alone in murine hindlimb lymphedema models. These results suggest that MSCs significantly promote the proliferation of LEPCs through the activation of the PI3K/Akt/mTOR pathway in LEPCs by secreting IGF-1, and that IGF-1 also inhibits apoptosis and regulates cell metabolism. …"

Table 1_Multi-omics analysis reveals that low cathepsin S expression aggravates sepsis progression and worse prognosis via inducing monocyte polarization.xlsx حسب Xiao-Ting Luo (20836646)

"…Inflammatory markers (p < 0.05) and migration ability of LPS-activated monocytes were significantly reduced after CTSS agonist. In addition, CTSS agonist decreased the pulmonary tissue monocyte/macrophages infiltration in septic mice.…"

DataSheet1_Study on the effects of laser shock peening on the microstructure and properties of 17-7PH stainless steel.docx حسب Kangwen Li (19921167)

"…The microhardness of the specimens shows a decreasing trend with increasing power density. When the power density is 2.79 GW/cm², the microhardness of the specimen significantly increases to 462.94 HV0.5, which is 22.26% higher than that of the non-peened specimen.…"

Table1_CD34 evaluation of microvasculature in lung adenocarcinoma and its microvascular density predicts postoperative tumor recurrence.xlsx حسب Zijian Qiu (17560477)

"…Thus, the detection of intratumoral MVD is of great significance for understanding disease progression and predicting patient prognosis.…"

Oligonucleotides used for vector clone. حسب Mingyi Xu (5575871)

"…In this work, we found that RNA2.7 deletion significantly decreased the viability of HCMV-infected cells, while treatment with ferroptosis inhibitor Fer-1 rescued the infection-induced cell death, demonstrating an anti-ferroptosis role of RNA2.7. …"

<b>Human Milk Oligosaccharides Mitigate Infant </b><b>Diarrhea</b><b> </b><b>and </b><b>Anxiety</b><b>-like </b><b>Behaviors</b><b> via Gut Microbiota Modulation in an EPEC O127 In... حسب wang wenxiu (21257327)

"…Meanwhile, the mice received HMOs containing 2’-fucosyllactose (2’-FL, 1 g/kg) and/or lacto-N-neotetraose (LNnT, 0.3 g/kg) for three weeks. The results showed that HMOs significantly alleviated diarrhea symptoms, mitigated anxiety-like behaviors, reduced colon inflammation, and <a href="" target="_blank">restored gut barrier integrity</a>. …"

Table 2_Gandouling ameliorates Wilson’s disease-associated liver fibrosis in mice with associated faecal microbiome and metabolome remodeling.xlsx حسب Lulu Tang (2664904)

"…Additionally, to detect alterations in the intestinal bacterial composition and metabolites, faecal samples were examined using non-targeted metabolomics and 16S rRNA sequencing.</p>Results<p>The administration of GDL demonstrated anti-fibrotic effects on the liver, decreased serum inflammatory markers, ameliorated liver histopathology, and restored ileal permeability in the model group, as compared to the control group. …"

Data Sheet 1_Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective.pdf حسب Didar Murad (12220805)

"…We explored that the decreased levels of complement factor H and C1-inhibitor significantly elevate these components, whereas tissue factor pathway inhibitor and alpha-2-macroglobulin have more modest effects. …"

data.zip حسب Zhizhang Dong (21158474)

"…Compared with the control group, the thickness of retina in the experimental group was significantly reduced (t=5, P=0.0075), the number of retinal pigment epithelium was statistically decreased (t=4.243, P=0.0132), and the pyrolytic related proteins NLRP3, Caspase-1, GSDMD, IL-1β and IL-18 were strongly red positive in retinal pigment epithelium (P<0.05). …"

Image 8_RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.jpeg حسب Chen Wang (88408)

"…In vivo, RBM15 depletion significantly delayed tumor progression and enhanced CD8⁺ T cell infiltration and activation in the tumor microenvironment.…"