Presentation 1_Extraction of anthocyanins from purple sweet potato: evaluation of anti-inflammatory effects in a rheumatoid arthritis animal model, mechanistic studies on inflammat... by Jingjian Dong (12458730)

“…Meanwhile, exosomes were extracted from MH7A cells and loaded with PSPA, then co-incubated with inflammatory cells to observe the targeting capability of the drug-loaded exosomes.</p>Results<p>PSPA significantly reduced joint swelling and structural damage in CIA rats, with the highest dose (40 mg/kg) reducing tissue hyperplasia and inflammatory infiltration. …”

Image 1_CD3zeta-mediated modulation of TCR signaling: a novel strategy for neuroprotection in retinal ganglion cell degeneration.jpeg by Kexin Xu (757891)

“…Changes in inflammatory cytokine profiles were assessed to examine the broader impact of TCR modulation.</p>Results<p>CD3ζ knockdown significantly improved RGC survival by reducing apoptosis and necroptosis. …”

Data Sheet 1_Prognostic value of lymph node ratio in patients with non-small cell lung cancer: a systematic review and meta-analysis.zip by Junhuang Zheng (21629486)

“…High LNR was significantly associated with decreased overall survival (OS) (multivariable HR=1.76, 95% CI=1.36-2.27; univariable HR=2.26, 95% CI=1.95-2.63) and increased risk of shorter disease-free survival (DFS) (multivariable HR=1.66, 95% CI=1.48-1.88). …”

Image 6_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif by Ying Dong (41989)

“…MR analysis was then performed using summary statistics from the EBI database (n = 484,598) to assess the putative relationships between candidate genes and psoriasis risk.</p>Results<p>Seven genetically informed candidate genes were identified as being significantly associated with psoriasis susceptibility. …”

Data Sheet 3_Aurantii Fructus extract alleviates DSS-induced colitis in mice via regulating NF-κB and Nrf2/HO-1 signaling pathways and modulating intestinal microbiota.zip by JunBao Yu (22442218)

“…Additionally, cecal contents were subjected to 16S rRNA gene sequencing to analyze changes in the intestinal microbiota.</p>Results<p>AFE treatment significantly alleviated the severity of colitis, as evidenced by reduced DAI scores, attenuated colon shortening, and improved histopathological damage. …”

Table 5_Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo.docx by Yan Fan (575147)

“…This secretion was reinforced by the above sera. IGFBP5 decreased in ALI mice’s blood, while its supplement exacerbated inflammation. …”

Data Sheet 3_Beyond salt tolerance: SOS1-13’s pivotal role in regulating the immune response to Fusarium oxysporum in Solanum phureja.docx by Liqin Liang (652560)

“…Conversely, silencing the ortholog gene NbSOS1-13 in Nicotiana benthamiana showed more accumulation of ROS, serious cell necrosis, reduced activities of SOD and CAT, significantly increased MDA level, obvious leaf wilting, decreased tolerance to infection, and reduced leaf stomatal closure rate and accelerated stomatal area. …”

Image 1_Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors.tif by Yiping Cao (1229856)

“…Pharmacological activation of local PVT A_2AR with its agonist CGS21680 induced significantly decreased 50% paw withdrawal threshold (50%PWTs) and paw withdrawal latency (PWLs), as measured by the Von Frey test and Hargreaves test in adult mice. …”

Data Sheet 1_Aurantii Fructus extract alleviates DSS-induced colitis in mice via regulating NF-κB and Nrf2/HO-1 signaling pathways and modulating intestinal microbiota.zip by JunBao Yu (22442218)

“…Additionally, cecal contents were subjected to 16S rRNA gene sequencing to analyze changes in the intestinal microbiota.</p>Results<p>AFE treatment significantly alleviated the severity of colitis, as evidenced by reduced DAI scores, attenuated colon shortening, and improved histopathological damage. …”

Supplementary file 1_Parasite populations of river otter and mink in Western Canada, and the first report of the zoonotic trematode Alaria mustelae in river otter in North America.... by Kyle M. Shanebeck (21766418)

“…Increasing intensities of infection were significantly related to decreasing nutritional condition.…”

Image 1_Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.tif by Miguel Ângelo-Dias (20936444)

“…We evaluated 74 lymphocyte subsets, including follicular and non-follicular CD4 and CD8 T cells, and functional markers CD69 and PD-L1, under basal and stimulated conditions.</p>Results<p>Pregnancy was associated with decreased total B cell counts, particularly within transitional and anergic naïve subsets, and increased activated naïve and memory B cells. …”

Table2_Slow-release boron fertilizer improves yield and nutritional profile of Beta vulgaris L. grown in Northeast China by increasing boron supply capacity.docx by Zhenzhen Wu (4747098)

“…Boron fertilizer can increase soil B content and significantly improve crop yield and quality. At present, the effects of slow-release B fertilizer on beet root yield and quality remain unclear. …”

Image 1_Association of inflammatory biomarkers with new functional morbidity at hospital discharge in children who survive severe sepsis.pdf by Mallory A. Perry-Eaddy (20842868)

“…The primary outcome was new functional morbidity, defined as at least a one-point increase in the pediatric overall performance category from baseline to hospital discharge.</p>Results<p>New functional morbidity occurred in 38 children (32%) and was associated with increased plasma levels of interleukin (IL)-6, IL-18, sIL-2Ra, MCP1, IL-8 (CXCL8), sIL-1RII, IL-10, MIP1a, and IL-2r and decreased RANTES (CCL5) (p < .001) at all three timepoints. …”

Table 1_Multi-omics reveals that NOTCH1 promotes cervical cancer progression and reduces radiosensitivity.docx by Aihua Guo (13267712)

“…In addition, patients with high NOTCH1 expression showed decreased plasma cell infiltration in the microenvironment. …”

Table 2_Relationships between rumen methanogens and fungal communities and their response to changes in alfalfa forms and starch in sheep diets.xlsx by Wenliang Guo (14825407)

“…The relative abundance of Aspergillus in the AHLR diet was significantly higher than in the AS diets (P < 0.01), and the relative abundance of Occultifur and Meyerozyma were decreased in the AH diets than in the AS diets (P < 0.05). …”

Novel Vanillic Acid-Loaded <i>In Situ</i> Gels: Development, Characterization, <i>In Vitro</i> Evaluation for Enhanced Wound Healing and Skin Irritation Test by Gökçe Mutlu Sonat (21726037)

“…Moreover, IN15-VA significantly reduced prostaglandin E2 levels, controlled IL-6 increase and exhibited non-irritating properties. …”

Data Sheet 2_Renewable energy consumption optimization allocation strategy for a regional microgrid based on a shared energy storage mechanism.pdf by Hongde Ma (20137539)

“…Finally, the rationality and effectiveness of the proposed bilayer optimization model were verified through a case analysis of three typical scenarios. The research results show that after configuring shared energy storage, the operating cost of the regional microgrid system decreases by 15.12%, the new energy consumption rate increases to 97.44%, and the shared energy storage service provider can recover the investment cost within 4.62 years. …”

Data Sheet 1_Pharmacist-led surgical medicines prescription optimization and prediction service improves patient outcomes - a machine learning based study.docx by Xianlin Li (2004964)

“…In Phase 3, the acceptance rate of pharmacist recommendations rose to 71.3%, while the length of stay, total hospitalization costs, and medication costs significantly decreased (p < 0.05), indicating overall improvement compared to Phase 1.…”

Image 2_Neonatal supplementation of oleamide during suckling ameliorates maternal postpartum sleep interruption-induced neural impairment and endocannabinoid dysfunction in early a... by Linxi Qian (555385)

“…Introduction<p>Postpartum sleep disturbances in women are common and can significantly affect maternal mental health and breastfeeding. …”

Table 1_Association between body composition in early pregnancy and the risk of gestational diabetes mellitus.docx by Yan Li (23143)

“…Logistic regression and restricted cubic spline (RCS) analyses were performed to examine the associations between body composition and GDM risk.</p>Results<p>Compared with the bottom tertile, the top tertile levels of PBF and FM were significantly associated with an increased risk of GDM, with adjusted odds ratios (ORs) and corresponding 95% confidence intervals (95% CI) of 1.77 (1.13, 2.77) and 1.99 (1.23, 3.20), respectively. …”