Video 1_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 by Lina Ouologuem (22489549)

“…These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…”

Image 2_Characterizing HLA-A2-restricted CD8+ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients.tif by Chanchan Xiao (9522614)

“…We identified two epitopes associated with decreased CD8 T-cell reactivity post-Omicron variant emergence. …”

Baidu heat map average. by Tingting Cui (564531)

“…The factors within the Park attributes (G1) and the park’s social media level (G4) showed a two-way interaction strength increase. (4)The coefficients of influence of impact factors on the space heterogeneity of vacation park vitality exhibit significant variation. The positive indicators have a spatial distribution that decreases from the northwest to the southeast, with the old city district having higher coefficients than the new city district. …”

Data Sheet 1_Overexpression of KPC contributes to ceftazidime-avibactam heteroresistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae.docx by Yitan Li (1449217)

“…Silencing bla_KPC expression significantly decreased the CZA MIC in resistant subpopulations with high bla_KPC expression and hindered the emergence of CZA heteroresistance in their parental strains. …”

Data Sheet 1_Temperature extremes across elevation gradients: evidence from two German mountain observatories.pdf by Monica Ionita (6486275)

“…Temperature extremes have also changed markedly: cold extremes have declined significantly at both locations (e.g., the duration of cold spells has decreased by 16 days at Hohenpeißenberg and by 10 days at Zugspitze, over the period 1981–2024), while warm extremes exhibit a pronounced rise, especially in the Warm Spell Duration Index (WSDI), which has nearly doubled since the 1980s. …”

Table 1_Automated radiosynthesis and clinical experience of [18F]SMBT-1 PET imaging for in vivo evaluation of reactive astrocyte in Parkinson's disease: a pilot study.docx by Peerapon Kiatkittikul (22801874)

“…Healthy control also showed globally increased [¹⁸F]SMBT-1 uptake. There was no significant correlation between the degree of [¹⁸F]FDOPA uptake and [¹⁸F]SMBT-1 uptake in any brain region.…”

Data Sheet 1_Linarin alleviates colonic barrier dysfunction induced by enterotoxic Escherichia coli in weaned piglets by regulating the gut microbiota and metabolic pathways.docx by Qianqian Zhang (587342)

“…</p>Results<p>Linarin supplementation significantly ameliorated colonic crypt hyperplasia, increased goblet cell numbers, and decreased diarrhea incidence following ETEC infusion. …”

Image 1_Oral supplementation with Lactobacillus fermentum MC018 improves intestinal health, immune response, and growth performance of Zi geese infected with Escherichia coli XH197... by Yang Li (7082)

“…Introduction<p>Escherichia coli infection causes severe diarrhea, decreases growth performance, and increases mortality of poultry, which imposes a significant economic burden on the poultry industry and severely limits its growth.…”

Image 1_Ketogenic diet–induced changes in methylation status and neuropeptide signaling: relationships between S-adenosylmethionine (AdoMet), orexin-A, and metabolic health.pdf by Laura Mosca (704904)

“…Circulating AdoMet (−75.7%) and Orexin-A (−7.2%) levels also decreased significantly. AdoMet levels positively correlated with body weight, BMI, visceral adipose tissue, total cholesterol, fasting glycemia, triglycerides, HbA1c, and notably Orexin-A (R² = 0.3848, p < 0.0001).…”

The epidemiology and gene mutation characteristics of pyrazinamide-resistant <i>Mycobacterium tuberculosis</i> clinical isolates in Southern China by Nan Wang (21935)

“…These findings indicate that <i>rpsA</i> and <i>panD</i> may not significantly contribute to the development of PZA resistance in clinical <i>M. tuberculosis</i> isolates.…”

Table 1_Species-level taxonomic characterization of gut microbiota in HIV-infected individuals.xlsx by Jiali Chen (5696)

“…We recruited 114 individuals in the PWH group and 58 individuals in the HC group, from whom fecal samples were collected for 16S rRNA gene sequencing of the V3–V4 region. Significant differences in α diversity and β diversity (p-values < 0.05) were observed between the two groups. …”

Data Sheet 1_Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy.zip by Han-han He (20594477)

“…The immune infiltration analysis showed that there was a significantly increased abundance of macrophages and a decreased abundance of CD4 and CD8 T cells, including Tr1, nTreg, Tfh, CD8 naïve, cytotoxic T cells and effector memory T cells in the epilepsy group. …”

DataSheet1_Anaerobic membrane bioreactor (AnMBR) with external ultrafiltration membrane for the treatment of sugar beet vinasse.PDF by Beatriz Egerland Bueno (20143764)

“…L^-1 d^-1 and fluxes of 12 and 14 LMH, the COD removal efficiency decreased to 77% ± 11% and 73% ± 7.9%, respectively. …”

Data Sheet 1_Impact of liposomal bupivacaine on subjective recovery quality after surgery: a meta-analysis of randomized controlled trials.docx by Longyi Zhang (11120151)

“…The LB group also exhibited lower cumulative morphine-equivalent opioid consumption within 72 h after surgery, a reduced incidence of PONV, and significantly higher patient satisfaction scores.</p>Conclusion<p>The use of LB was associated with improved QoR scores within 72 h after surgery, a reduced incidence of PONV, and decreased opioid consumption. …”

Data Sheet 1_Therapeutic efficacy of a galactoglucan from Pleurotus citrinopileatus in constipation: modulation of aquaporin signaling and intestinal barrier.pdf by Yi Gao (112914)

“…The oral administration of PCP-g resulted in a significant reduction in constipation symptoms, as indicated by an increase in fecal water content, normalization of pellet formation, enhancement of total fecal mass, decreased latency to the first stool, and improved intestinal propulsion. …”

Image 4_Species-level taxonomic characterization of gut microbiota in HIV-infected individuals.pdf by Jiali Chen (5696)

“…We recruited 114 individuals in the PWH group and 58 individuals in the HC group, from whom fecal samples were collected for 16S rRNA gene sequencing of the V3–V4 region. Significant differences in α diversity and β diversity (p-values < 0.05) were observed between the two groups. …”

Data Sheet 1_The multivalent passive immune-protective vaccines of egg yolk immunoglobulin Y derived from live or inactivated Pseudomonas anguilliseptica against aquaculture pathog... by Pan Cui (5726669)

“…Furthermore, the structures of the kidney, spleen, and intestinal tissues were intact, and the expression of p53 and γH2A.X decreased in the kidney.</p>Conclusion<p>L-PA-IgY and I-PA-IgY can resist multiple bacterial infections and have immunoprotective effects with no significant differences. …”

Table 1_Analysis of growth variations and expression patterns of auxin response factor gene family in Fallopia multiflora under different light qualities.xlsx by Wenze Liu (22817513)

“…Results showed that the blue-light treatment group significantly increased the leaf area by 46.19% and chlorophyll content by 7.35%, decreased the plant height by 20.92%, and increased the THSG content in roots by 28.37% and in stems by 27.15%. …”

Data_Sheet_1_Safety and efficacy of plasmapheresis in treatment of acute fatty liver of pregnancy—a systematic review and meta-analysis.docx by Sujata Siwatch (19867233)

“…Biochemical parameter analysis demonstrated significant improvement post-PP/PE treatment, including decreased bilirubin (MD: 8.30, 95% CI: 6.75 to 9.84), AST (MD: 107.25, 95% CI: 52.45 to 162.06), ALT (MD: 111.08, 95% CI: 27.18 to 194.97), creatinine (MD: 1.66, 95% CI: 1.39 to 1.93), and Prothrombin time (MD: 5.08, 95% CI: 2.93 to 7.22).…”

PbCBP-O is required for efficient midgut traversal. by Dominika Kwecka (22170493)

“…In all relevant panels, statistical significance is indicated as: ns = not significant, ** = p < 0.01, *** = p < 0.001 and **** = p < 0.0001.…”