Showing 1,561 - 1,580 results of 21,342 for search '(( significant role decrease ) OR ( significant decrease decrease ))', query time: 0.29s Refine Results
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    Advantages of Novel Anti-cancer Selenosemicarbazones: Preferential Reactivity of Their Fe(III), Cu(II), and Zn(II) Complexes with Key Physiological Reductants/Ligands Versus Isoste... by Mahendiran Dharmasivam (14165426)

    Published 2025
    “…Considering this: (1) [Fe(PPP4pSe)<sub>2</sub>]<sup>+</sup> demonstrated increased reduction relative to [Fe(PPP4pT)<sub>2</sub>]<sup>+</sup> with glutathione and l-cysteine, while l-ascorbate led to comparable reduction; (2) glutathione led to complete dissociation of [Zn(PPP4pSe)<sub>2</sub>], while incomplete dissociation of [Zn(PPP4pT)<sub>2</sub>] occurred; and (3) [Cu(PPP4pSe)Cl] demonstrated complete coordinate sphere substitution with glutathione, l-cysteine, and l-ascorbate, whereas [Cu(PPP4pT)Cl] demonstrated partial substitution. The role of glutathione in all three latter reactions is significant, given the greater reactivity of the selenosemicarbazone, and glutathione’s key role in selenosemicarbazone and thiosemicarbazone anticancer activity.…”
  11. 1571

    Advantages of Novel Anti-cancer Selenosemicarbazones: Preferential Reactivity of Their Fe(III), Cu(II), and Zn(II) Complexes with Key Physiological Reductants/Ligands Versus Isoste... by Mahendiran Dharmasivam (14165426)

    Published 2025
    “…Considering this: (1) [Fe(PPP4pSe)<sub>2</sub>]<sup>+</sup> demonstrated increased reduction relative to [Fe(PPP4pT)<sub>2</sub>]<sup>+</sup> with glutathione and l-cysteine, while l-ascorbate led to comparable reduction; (2) glutathione led to complete dissociation of [Zn(PPP4pSe)<sub>2</sub>], while incomplete dissociation of [Zn(PPP4pT)<sub>2</sub>] occurred; and (3) [Cu(PPP4pSe)Cl] demonstrated complete coordinate sphere substitution with glutathione, l-cysteine, and l-ascorbate, whereas [Cu(PPP4pT)Cl] demonstrated partial substitution. The role of glutathione in all three latter reactions is significant, given the greater reactivity of the selenosemicarbazone, and glutathione’s key role in selenosemicarbazone and thiosemicarbazone anticancer activity.…”
  12. 1572

    Raw data. by Camilla Albano (16446679)

    Published 2025
    “…Blocking CD36 function with SSO further decreased viral infectivity, demonstrating the critical role of lipid uptake in HSV-1 life cycle. …”
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