S1 Data - by Richard Junior Zapata Dongo (17912565)

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Average activity profiles (columns 1 & 3) and double-plotted actograms (col. 2 & 4) of female and male <i>M. marinus</i> (col. 1 & 2) and <i>G. pulex</i> (col. 3 & 4). by Charlotte N. Underwood (5043110)

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Combination therapy exhibited apoptosis in Ba/F3 EML4-ALKmutant cell models. by Richard Junior Zapata Dongo (17912565)

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Ba/F3 EML4-ALK^mutants exhibit variable dose-response to ABT-199 treatment. by Richard Junior Zapata Dongo (17912565)

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Average activity profiles (left column) and double-plotted actograms (right column) of <i>Marinogammarus marinus</i> (A-B) and <i>Gammarus pulex</i> (C-D) under the LD light regime... by Charlotte N. Underwood (5043110)

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Molecular docking showed that ABT-199 can fit into active site of ALK^Mutant. by Richard Junior Zapata Dongo (17912565)

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The binding energy values of ATP, ALK inhibitors and ABT-199 to ALK were obtained from AlphaFold and modeled protein structures. by Richard Junior Zapata Dongo (17912565)

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Amino acids interactions and binding energy describe that ABT-199 binds to ALK^Mutant. by Richard Junior Zapata Dongo (17912565)

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Activity of female and male <i>M. marinus</i> (left column) and <i>G. pulex</i> (right column). by Charlotte N. Underwood (5043110)

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Average activity profiles (columns 1 & 3) and double-plotted actograms (col. 2 & 4) of <i>G. pulex.</i> by Charlotte N. Underwood (5043110)

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Western blot analysis of drug combinations. by Richard Junior Zapata Dongo (17912565)

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ALKL1196M –ABT199 interactions. by Richard Junior Zapata Dongo (17912565)

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Behavioural parameters of <i>Marinogammarus marinus</i> and <i>Gammarus pulex</i> activity under varying light/dark cycles. by Charlotte N. Underwood (5043110)

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Average activity profiles (columns 1 & 3) and double-plotted actograms (col. 2 & 4) of <i>M. marinus.</i> by Charlotte N. Underwood (5043110)

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ALK^wt–ABT199 interactions. by Richard Junior Zapata Dongo (17912565)

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BCL2 protein keeps their expression in different conditions treatment nevertheless each EML4-ALK cell modells exhibit variable expression. by Richard Junior Zapata Dongo (17912565)

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ALK inhibitors (Positive control) and ABT199 (Proposed binding) in complex with the ALK active side. by Richard Junior Zapata Dongo (17912565)

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Locomotor activity of <i>Marinogammarus marinus</i> (left column) and <i>Gammarus pulex</i> (right column). by Charlotte N. Underwood (5043110)

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BCL2 antiapoptotic protein exhibits heterogeneous expression in Ba/F3 EML4-ALK^mutants. by Richard Junior Zapata Dongo (17912565)

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Loewe synergy-antagonism score analysis shows additive and synergistic effects after ALKi and ABT-199 combination treatment. by Richard Junior Zapata Dongo (17912565)

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