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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. …”
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A New Genetic-Based Tabu Search Algorithm For Unit Commitment Problem
Published 2020“…This paper presents a new algorithm based on integrating the use of genetic algorithms and tabu search methods to solve the unit commitment problem. …”
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Scatter search for protein structure prediction. (c2008)
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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A new tabu search algorithm for the long-term hydro scheduling problem
Published 2002“…A new efficient algorithm to solve the long-term hydro scheduling problem (LTHSP) is presented in this paper. The algorithm is based on using the short-term memory of the tabu search (TS) approach to solve the nonlinear optimization problem in continuous variables of the LTHSP. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Analysis of Diabetes Apps to Assess Privacy-Related Permissions: Systematic Search of Apps
Published 2021“…</p><h3>Methods</h3><p dir="ltr">We developed a semiautomatic app search module capable of retrieving Android apps’ privacy-related information, particularly the dangerous permissions required by apps, with the aim of analyzing privacy aspects related to diabetes apps. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Efficient multi-objective neural architecture search framework via policy gradient algorithm
Published 2024“…<p>Differentiable architecture search plays a prominent role in Neural Architecture Search (NAS) and exhibits preferable efficiency than traditional heuristic NAS methods, including those based on evolutionary algorithms (EA) and reinforcement learning (RL). …”
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MDPF: Minimum Distance Packet Forwarding for Search Applications in Mobile Ad Hoc Networks
Published 2009“…This paper introduces a message forwarding algorithm for search applications within mobile ad hoc networks that is based on the concept of selecting the nearest node from a set of designated nodes. …”
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A memristive all-inclusive hypernetwork for parallel analog deployment of full search space architectures
Published 2024“…<p dir="ltr">In recent years, there has been a significant advancement in memristor-based neural networks, positioning them as a pivotal processing-in-memory deployment architecture for a wide array of deep learning applications. …”
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A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation
Published 2009“…To investigate the contribution of genetic variation in DNA methyltransferase (DNMT) genes to such epigenetic variation, we performed a systematic search for polymorphisms in all known human DNMT genes [ DNMT1 , DNMT3A , DNMT3B , DNMT3L and DNMT2 (TRDMT1 )] in 192 healthy males and females. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”