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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A New Genetic-Based Tabu Search Algorithm For Unit Commitment Problem
منشور في 2020"…This paper presents a new algorithm based on integrating the use of genetic algorithms and tabu search methods to solve the unit commitment problem. …"
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Scatter search for protein structure prediction. (c2008)
منشور في 2008احصل على النص الكامل
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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A new tabu search algorithm for the long-term hydro scheduling problem
منشور في 2002"…A new efficient algorithm to solve the long-term hydro scheduling problem (LTHSP) is presented in this paper. The algorithm is based on using the short-term memory of the tabu search (TS) approach to solve the nonlinear optimization problem in continuous variables of the LTHSP. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Analysis of Diabetes Apps to Assess Privacy-Related Permissions: Systematic Search of Apps
منشور في 2021"…</p><h3>Methods</h3><p dir="ltr">We developed a semiautomatic app search module capable of retrieving Android apps’ privacy-related information, particularly the dangerous permissions required by apps, with the aim of analyzing privacy aspects related to diabetes apps. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Efficient multi-objective neural architecture search framework via policy gradient algorithm
منشور في 2024"…<p>Differentiable architecture search plays a prominent role in Neural Architecture Search (NAS) and exhibits preferable efficiency than traditional heuristic NAS methods, including those based on evolutionary algorithms (EA) and reinforcement learning (RL). …"
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MDPF: Minimum Distance Packet Forwarding for Search Applications in Mobile Ad Hoc Networks
منشور في 2009"…This paper introduces a message forwarding algorithm for search applications within mobile ad hoc networks that is based on the concept of selecting the nearest node from a set of designated nodes. …"
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