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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Grid Iron Patterns & Detached Villas as the Main Drivers of Sharjah City’s Urban Sprawl
Published 2021“…On the demographic side, the massive external population migration that trickled towards the city resulted in a major defect in its demographic structure, which represented a decrease in the percentage of the citizen population to only about 10% of the non-citizen population. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Assessing the Impact of Water Efficiency Policies on Qatar’s Electricity and Water Sectors
Published 2021“…The efficient use of water in different sectors of the economy results in a combined saving of 1222 GWh (8.1%) or 594,000 tons CO<sub>2</sub>. …”
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Technological, organisational and environmental determinants of smart contracts adoption: UK construction sector viewpoint
Published 2020“…The results generated from linear regression analysis suggest that the following four factors have a significant influ ence on the adoption of smart contracts: supply chain pressure, competitive pressure, top man agement support, and observability. …”
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The Sustainability Inclusion in Project Contracts and its Impact on the Performance of UAE Public Sector Projects
Published 2024“…The survey included feedback from 100 respondents who have been from public sector projects in the UAE. The descriptive analysis reflected that sustainability inclusion has been essential for public sector projects as it improved the performance and quality of the same. …”
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Determinants of Off-Balance Sheet Business in the Case of GCC Banking Sectors during Covid-19
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The Impact of Implementing Maturity Models on IT Project Performance
Published 2021“…Appropriate scientific analysis methods were used to analyze the data, including descriptive analysis, reliability, correlation, linear regression, and multiple regression. This research found that the implementation of maturity models have a significant relationship with the performance of IT projects, and plays an important role in influencing. …”
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