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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition
Published 2003“…Prednisolone-treated groups revealed significantly lower intestinal absorption. However, prednisolone-treated high-carbohydrate (HC) fed rats showed significantly higher weight gain, concomitant with a significant increase in feed efficiency. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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UniBFS: A novel uniform-solution-driven binary feature selection algorithm for high-dimensional data
Published 2024“…Despite its importance, the constantly increasing search space of high-dimensional datasets poses significant challenges to FS methods, including issues like the "curse of dimensionality," susceptibility to local optima, and high computational and memory costs. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Extended high gain DC‐DC converter with switched‐inductors, switched‐capacitors and soft‐switching: Analysis and implementation
Published 2024“…Simple auxiliary resonant elements are added on the primary leg of the converter to provide design freedom for soft‐switching operation. The significant merits of the proposed converter are lesser voltage and current stresses, high voltage gain with reduced component count and better efficiency. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Triple helix components supporting STEM education to increase future STEM careers in the United Arab Emirates
Published 2023“…Further investigation is needed to gain more information about the significant differences in perspectives between and within the stakeholder clusters.…”
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An evaluation of recruitment and selection processes in three organizations in the UAE
Published 2011“…The use of formal and informal recruitment and selection procedures for Human Resource Management has increased dramatically in United Arab Emirates (UAE) organizations. …”
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The Impact of Artificial Intelligence on Institutional Recruitment and Selection Processes
Published 2024“…The research sheds light on the significance of AI in recruitment and selection processes, providing insights into how it can improve the efficiency and accuracy of selection procedures while reducing human biases. …”
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Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation
Published 2021“…Our observations also suggest that the variants that predispose to PDB in humans probably do so by causing a gain-in-function of RIN3.</p><p dir="ltr">Correction: Targeted Inactivation of <i>Rin3</i> Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation <a href="https://doi.org/10.1007/s00223-021-00849-w" target="_blank">https://doi.org/10.1007/s00223-021-00849-w</a>, published online 19 April 2021.…”