Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy by Samson Mathews Samuel (18808246)

“…Additionally, treatment with metformin and 2DG (5 mM) inhibited the Akt/mTOR pathway and down-regulated the cell-cycle-related proteins such as p-cyclin B1 (S147) and cyclins D1 and D2 when compared to cells that were treated with either 2DG or metformin alone. Treatment with a combination of 2DG (5 mM) and metformin (2 mM) also significantly decreased cell proliferation, migration and tubulogenic capacity when compared to cells that were treated with either 2DG or metformin alone. …”

Do near-bedtime usage of smartphones and problematic internet usage really impact sleep? A study based on objectively recorded usage data by Aftab Alam (5158601)

“…</p><h3> Results</h3><p dir="ltr">The multivariate linear regression showed that the increase in PIU (β = −0.231, p < 0.001) and smartphone usage two hours before sleep (β = −0.246, p < 0.001) led to decrease in sleep duration. Regarding sleep distraction, multivariate linear regression analysis revealed that two hours before sleep was a significant and positive predictor of sleep distraction (β = 0.197, p = 0.003), whereas PIU was not significant. …”

Advanced direct air capture of CO₂ using air conditioning systems: a life cycle assessment by Namra Mir (17017734)

“…The integrated system exhibits significantly reduced environmental impacts compared to a standalone DAC unit. …”

Exergames versus self-regulated exercises with instruction leaflets to improve adherence during geriatric rehabilitation: a randomized controlled trial by Peter Oesch (3572426)

“…Adherence was comparable at day one (38 min. in the EG and 42 min. in the CG) and significantly higher in the CG at day 10 (54 min. in the CG while decreasing to 28 min. in the EG, <i>p</i> = 0.007, ES 0.94, 0.39–0.151). …”

Double versus triple arthrodesis for adult-acquired flatfoot deformity due to stage III posterior tibial tendon insufficiency: a prospective comparative study of two cohorts by Amr A. Fadle (14150298)

“…Both double and triple arthrodesis groups had a statistically significant improvement of the mean AOFAS hindfoot score post-operatively (71.46 ± 7.77 vs. 88.38 ± 3.66, p < 0.001) and (66.9 ± 7.69 vs. 85 ± 5.83, p < 0.001), respectively. …”

The effect of the local inertial term on the fluid flow in channels partially filled with porous material by Abu-Hijleh, B.A.

“…Also, it is found that the deviation between the predictions of the transient and the quasi-steady models is more significant in the porous domain and the deviation decreases as the time proceeds.…”
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A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase by Ahmed S. Ibrahim (10049522)

“…In the presence of arachidonic acid, additional eicosanoids generated by 12/15-LOX, including 12- and 11-HETEs, were significantly increased. Fluorescein angiography and retinal albumin leakage showed a significant decrease in retinal hyperpermeability in streptozotocin-induced diabetic mice lacking 12/15-LOX compared with diabetic WT mice. …”

Regional variations in incidence of surgical site infection and associated risk factors in women undergoing cesarean section: A systematic review and Meta-Analysis by Nazmul, Islam

“…Meta-regression showed a significant decrease in SSI incidence in HICs. …”
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Cardiorespiratory Fitness and Performance Adaptations to High-Intensity Interval Training: Are There Differences Between Men and Women? A Systematic Review with Meta-Analyses by Merilyn Lock (9440240)

“…After sub-grouping, significant differences were present for PPO where the effect size was higher for well-trained women (g = 0.37) compared with well-trained men (g = 0.17), and for V̇ O_2max where interventions with a duration of 4 weeks or less had significantly smaller effect sizes compared with those longer than 4 weeks (p < 0.001). …”

Swimming exercise improves short‐ and long‐term memories: Time‐course changes by Mahmoud A. Alomari (14780446)

“…In this investigation, changes in the spatial hippocampal memory following a time-course of swimming exercise training were examined. …”

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy by Ajaz A. Bhat (12984701)

“…The tumor microenvironment (TME) contains several cell types, including fibroblasts, immune cells, adipocytes, stromal proteins, and growth factors, which play a significant role in supporting the growth and aggressive behavior of cancer cells. …”

Prevalence of polypharmacy and the association with non-communicable diseases in Qatari elderly patients attending primary healthcare centers: A cross-sectional study by Ayman Al-Dahshan (8962568)

“…<h3>Background </h3><p dir="ltr">Polypharmacy has become a global public health concern particularly in the elderly population. …”

Positional and dimensional temporomandibular joint osseous changes in patients treated with the forsus fatigue resistant device: a non-randomized clinical trial by Ramy Abdul-Rahman Ishaq (22928974)

“…In the treatment group, condylar width decreased significantly by 0.52 ± 0.92 mm, in contrast to an increase of 0.17 ± 0.35 mm in the control group (<i>P</i> = 0.010). …”

High flow nasal oxygen (HFNO) in the treatment of COVID-19 infection of adult patients from – An emergency perspective: A systematic review and meta-analysis by Nabil, Shallik

“…HFNO was associated with a significant decrease in mortality and intubation rates (0.28 (95% CI; 0.19, 0.39) and 0.28 (95% CI; 0.18, 0.41), respectively). …”
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Thermo-economic analysis of a novel P2X polygeneration system for hydrogen, ammonia, and methanol production with near-zero emissions by Laveet Kumar (11460088)

“…The system's levelized cost of hydrogen (LCOH) decreases significantly from $1.70/kg to $0.80/kg, and the levelized cost of electricity (LCOE) decreases from 4.30 ¢/kWh to 3.30 ¢/kWh. …”

Urban Geometry: The Effect of Height Diversity and Buildings Configuration on Thermal Performance and Cooling Load at Urban Scale. A Case Study in Dubai / UAE by SHAREEF, SUNDUS LUAY

“…The research found that a significant variation in building height reduces the cooling load more than a gradual height variation, and consequently offers more energy saving. …”
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Effects of the addition of a high energy density fuel, adamantane to diesel on its cetane number, sooting propensity, and soot nanostructural properties by Al Zaabi, Alanood

“…The addition of up to 6.75 wt% of adamantane in diesel significantly increased the smoke point of diesel from 18 to 29 mm (and threshold sooting index decreased by 44%), indicating a drastic drop in fuel sooting tendency. …”
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Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling by Khalifeh, Mohamad

“…Even though WTS initially decreased anxiety-like behaviors, prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. …”
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High flow nasal oxygen (HFNO) in the treatment of COVID-19 infection of adult patients from – An emergency perspective: A systematic review and meta-analysis by Nabil Shallik (15900256)

“…HFNO was associated with a significant decrease in mortality and intubation rates (0.28 (95% CI; 0.19, 0.39) and 0.28 (95% CI; 0.18, 0.41), respectively). …”

Hypoglossal nerve stimulation for obstructive sleep apnea in adults: An updated systematic review and meta-analysis by Warda A. Alrubasy (18021700)

“…</p><h3>Methodology</h3><p dir="ltr">A systematic search was conducted across the databases to collect baseline and postoperative outcome measures. …”