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significant source » significant burden (Expand Search)
changes decrease » larger decrease (Expand Search), change increases (Expand Search)
largest decrease » larger decrease (Expand Search), marked decrease (Expand Search)
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6821
Table 1_Shengxue Busui Decoction activates the PI3K/Akt and VEGF pathways, enhancing vascular function and inhibiting osteocyte apoptosis to combat steroid-induced femoral head nec...
Published 2025“…In vivo, SBD intervention significantly reduced bone structural damage and apoptosis, decreasing the rate of empty bone lacunae. …”
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6822
Impact of Pilates training on gait performance in individuals with unilateral transtibial amputation
Published 2025“…The intact side also showed increased step length (<i>p</i> = 0.009), while stance time (<i>p</i> = 0.011) and swing time (<i>p</i> = 0.005) decreased post-training. No changes in asymmetry were observed, regardless of walking speed (<i>p</i> > 0.05). …”
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6823
Table 1_Silicon application enhances drought resilience in buckwheat: a comparative study of three varieties.docx
Published 2025“…La Harpe had the highest MDA accumulation in roots, increased 5mC levels in leaves, and was the only line with decreased water use efficiency (WUE). Smuga exhibited the highest natural proline level and the strongest proline increase under drought. …”
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6824
Table 1_Pingwei Powder alleviates high-fat diet-induced colonic inflammation by modulating microbial metabolites SCFAs.xlsx
Published 2025“…Experimental validation showed that PWP significantly downregulated the levels of PI3K, pAKT/AKT, and pmTOR/mTOR in colonic tissue, thereby enhancing autophagy in colonic epithelial cells, as evidenced by decreased levels of P62 and increased LC3B-II/LC3B-I ratios. …”
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6825
Table 1_The global, regional, and national burden of pediatric stone disease: 1990–2021 and projections for the next two decades.docx
Published 2025“…Background<p>Pediatric stone disease, once considered rare, has gained significant attention over the past decade owing to its rapidly increasing incidence. …”
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6826
Data Sheet 1_Global, regional, and national burden of sudden infant death syndrome, 1990–2021: a comprehensive analysis of GBD 2021 data with insights into the impact during the CO...
Published 2025“…This study investigates whether the global SIDS burden has changed, particularly during the COVID-19 pandemic.…”
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6827
Pathogenicity variation of CC4821 <i>Neisseria meningitidis</i> in China from 2005 to 2024
Published 2025“…Results showed a significant increase in the recent prevalence of serogroup B isolates and enhanced adhesion and invasion abilities, whereas serogroup C isolates decreased significantly in number and decreased adhesion and invasion abilities. …”
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6828
Lingganwuweijiangxin Decoction suppresses allergic airway inflammation in Guinea pigs with cough variant asthma by regulating the treg/Th17 balance and the JAK1/STAT6 signaling pat...
Published 2025“…</p> <p>Compared to the control group, the model group showed significantly more coughs, which were markedly reduced by LD treatment (<i>p</i> = 0.0083 and <i>p</i> = 0.0117). …”
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6829
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6830
Data Sheet 1_Circulating extracellular vesicles and neutrophil extracellular traps contribute to endothelial dysfunction in preeclampsia.pdf
Published 2024“…</p>Results<p>VWF, VCAM-1, and ROS expression was significantly higher in cells exposed to PE sera vs. control (12.3 ± 8.1, 3.6 ± 2.3, and 1.8 ± 0.2, respectively, p < 0.05), though significantly lower in cells exposed to depleted PE (dPE) sera (6.1 ± 2.7, 0.7 ± 0.6, and 1.2 ± 0.1, respectively, vs. control, p < 0.05). …”
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6831
Supplementary file 1_Global trends in childhood urinary tract infections, 1990–2021: results from the GBD study.docx
Published 2025“…Temporal trends were quantified using: Segmented regression to compute Annual Percentage Change and Average Annual Percentage Change. Log-linear regression models to derive Estimated Annual Percentage Change with 95% confidence intervals (CI). …”
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6832
Chronic hyperpolarization of dFB<sup>23E10</sup>Ո<sup>84C10</sup> neurons promotes sleep and impairs sleep homeostasis.
Published 2025“…Two-tailed Mann–Whitney U tests revealed that sleep rebound is significantly decreased at all time points between controls and <i>dFB-Split>UAS-Kir2.1</i> female flies. …”
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6833
30-year trends in incidence of acute STEMI and NSTEMI in the Belgian Province of Luxembourg. A long-term follow-up of the MONICA-BELLUX registry
Published 2025“…</p><p>b) What this study adds</p><p>In a 30-year registry in Luxembourg using modern AMI definitions, overall, AMI incidence decreased significantly, primarily due to a 3.8-fold reduction in STEMI.…”
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6834
Table_1_Engaging Underserved Communities in COVID-19 Health Equity Implementation Research: An Analysis of Community Engagement Resource Needs and Costs.docx
Published 2025“…</p>Conclusions<p>Study findings indicate that the most significant investment of resources is required in the startup period. …”
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6835
Table 5_Global, regional, and national epidemiology of Intracerebral Hemorrhage among women of childbearing age (1990–2021): incidence, mortality, DALYs, and risk factor analysis.x...
Published 2025“…Background and Objectives<p>Intracerebral Hemorrhage (ICH) is a serious cerebrovascular condition that poses a significant health risk to women of childbearing age (WCBA) globally. …”
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6836
Table 4_Global, regional, and national epidemiology of Intracerebral Hemorrhage among women of childbearing age (1990–2021): incidence, mortality, DALYs, and risk factor analysis.x...
Published 2025“…Background and Objectives<p>Intracerebral Hemorrhage (ICH) is a serious cerebrovascular condition that poses a significant health risk to women of childbearing age (WCBA) globally. …”
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6837
Table 2_Global, regional, and national epidemiology of Intracerebral Hemorrhage among women of childbearing age (1990–2021): incidence, mortality, DALYs, and risk factor analysis.x...
Published 2025“…Background and Objectives<p>Intracerebral Hemorrhage (ICH) is a serious cerebrovascular condition that poses a significant health risk to women of childbearing age (WCBA) globally. …”
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6838
Supplementary Material for: Trends and Impact of Early Medical Complications in Acute Ischemic Stroke: Data from the Austrian Stroke Unit Registry
Published 2025“…The effect sizes didn’t change significantly through the observed years. Conclusions This study observed a significant reduction in the prevalence of early medical complications after acute ischemic stroke. …”
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6839
The impact of refractive error correction on health-related quality of life in nursing home residents in Armenia
Published 2025“…Those who had not corrected their vision reported no significant improvement in both PHC and MHC. There were no significant differences in baseline to follow-up mean change scores for PHC and MHC between those who corrected their vision and those who had not.…”
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6840
Table 3_Global, regional, and national epidemiology of Intracerebral Hemorrhage among women of childbearing age (1990–2021): incidence, mortality, DALYs, and risk factor analysis.x...
Published 2025“…Background and Objectives<p>Intracerebral Hemorrhage (ICH) is a serious cerebrovascular condition that poses a significant health risk to women of childbearing age (WCBA) globally. …”