Combating Chemoresistance in Breast Cancer: Exploring Tumor Microenvironment, Combination Therapies, and Drug Repurposing Strategies حسب Shazia Sofi (17764488)

"…Chemoresistance in cancer can arise from a variety of molecular mechanisms, including active drug expulsion (drug efflux), decreased drug uptake, enhanced DNA repair mechanisms, the ability of cancer cells to evade programmed cell death (apoptosis), the diversity in the population of cancer cells within a tumor (tumor heterogeneity), and significant alterations in the tumor microenvironment (TME), where interactions between cancer cells, cancer-associated fibroblasts, immune cells, and the extracellular matrix contribute to a supportive environment that allows tumors to survive treatment and escape therapy. …"

Table_1_Associations between metabolic score for visceral fat and adult lung functions from NHANES 2007–2012.docx حسب Jiacai Zhou (20325867)

"…When dividing the METS-VF into thirds, participants in the highest third exhibited significantly decreased levels of FEV1 (β: −342, 95%CI: −440, −245, p < 0.001), FVC (β: −312, 95%CI: −431, −192, p < 0.001), FEV1/FVC (β: −0.020, 95%CI: −0.030, −0.010, p < 0.001), and FEF25-75% (β: −424, 95%CI: −562, −285, p < 0.001). …"

Table 1_Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.docx حسب Yingchao Wu (2870927)

"…Existing therapeutic agents are generally accompanied by significant side effects. Here, we highlight Saikosaponin A (SSA), a promising natural metabolite characterized by low toxicity, demonstrating significant efficacy against breast cancer through the induction of cellular senescence.…"

Data Sheet 1_Investigation of the physiological and molecular regulatory mechanism of soluble sugar metabolism in Lavandula angustifolia Mill. under cold stress.docx حسب Yuchen Liang (8596404)

"…To investigate the mechanisms underlying cold tolerance in L. angustifolia and support economic development, we measured the sugar content and performed transcriptome analysis at temperatures of 30°C (control), 20°C, 10°C, and 0°C. …"

Data Sheet 1_Enhancing chronic low back pain management: an initial neuroimaging study of a mobile interoceptive attention training.pdf حسب Irina A. Strigo (9745472)

"…</p>Results<p>MyP led to significant decreases in PEG scores overall. Furthermore, MyP responders exhibited increased pain-related activation in key brain regions, including the contralateral posterior insula, bilateral ventral anterior insula, ventral anterior cingulate, dorsolateral prefrontal cortex, and nucleus accumbens. …"

<i>Neisseria</i> species on the tonsillar surface predicts favorable clinical outcomes in patients with Immunoglobulin A nephropathy who underwent tonsillectomy حسب Ryosuke Sato (615801)

"…However, the bacteria involved in the pathogenesis of IgAN have not been fully elucidated. In this study, we compared the differences in tonsillar bacterial flora between IgAN (<i>n</i> = 101) and recurrent tonsillitis (RT) (<i>n</i> = 117) based on swab cultures from tonsillar surfaces and the center of the tonsils. …"

Table 1_Oxidative balance score is independently associated with reduced prevalence of sarcopenia among US adults with metabolic syndrome.docx حسب Miaohong Wang (8975903)

"…The impact of age was significant, with OBS benefits only observed in those aged 40 and older.…"

Supplementary file 1_The effect of probiotics on the diarrhea and constipation outcomes in children: an umbrella review of systematic reviews and meta-analyses.docx حسب Qizheng Wang (6440891)

"…Also, it is successful in reducing diarrhea duration [weighted mean difference (WMD) = −1.85; 95% CI: −2.83, −0.86] and [standardized mean difference (SMD) = −0.94; 95% CI: −1.32, −0.56] significantly. …"

Data Sheet 1_Potential geographical distribution of Cordyceps cicadae and its two hosts in China under climate change.docx حسب Junyi Chen (776323)

"…</p>Results<p>The primary environmental variables were soil pH, mean diurnal range, annual precipitation, precipitation seasonality, annual mean temperature and precipitation of the driest month. …"

Figure 5 from Functional Profiling of p53 and RB Cell Cycle Regulatory Proficiency Suggests Mechanism-Driven Molecular Stratification in Endometrial Carcinoma حسب Zelei Yang (18491142)

"…The individual points for each cell line in the individual graph for each treatment represent the average of three experiments, and error bars represent standard error of the mean. An ordinary one-way ANOVA with Šídák’s multiple comparisons test was performed to assess the significance of the difference between either the 4 hour or the 24 hour timepoint and the 45 minute timepoint for each cell line within each treatment. …"

Table 1_Molecular epidemiological characteristics of pertussis in a pediatric hospital in Jinan City, China, 2022 to 2024.docx حسب Miao Liu (148274)

"…BP co-detection rates with specific pathogens—human rhinovirus, adenovirus, Haemophilus influenzae, Staphylococcus aureus, and Mycoplasma pneumoniae significantly increased (all P_trend < 0.05), whereas parainfluenza virus co-infections decreased (P_trend < 0.05). …"

3D culture raw data حسب Yaojun Luo (20296512)

"…Notably, N⁶-methyladenosine (m⁶A), the predominant internal modification on mRNAs in eukaryotes, was significantly decreased in 3D cultured eWAT preadipocytes at day 1 post-treatment with the MDI cocktail. …"

Data Sheet 1_Inverse associations of the lifestyle critical 9 with cardiorenal syndrome: the mediating role of the dietary inflammatory index.xlsx حسب Hongman Li (19546419)

"…The dose–response curve illustrates a linear relationship between LC9 and CRS; as LC9 increases, the occurrence of CRS decreases. DII shows a significant positive connection with CRS (p < 0.001), but DII indicates a decreasing trend when LC9 rises (β = −0.65, p < 0.001). …"

Table 1_Inverse associations of the lifestyle critical 9 with cardiorenal syndrome: the mediating role of the dietary inflammatory index.docx حسب Hongman Li (19546419)

"…The dose–response curve illustrates a linear relationship between LC9 and CRS; as LC9 increases, the occurrence of CRS decreases. DII shows a significant positive connection with CRS (p < 0.001), but DII indicates a decreasing trend when LC9 rises (β = −0.65, p < 0.001). …"

Table 1_Sijunzi San alleviates the negative energy balance in postpartum dairy cows by regulating rumen fermentation capacity.docx حسب Feifei Wang (195514)

"…The results revealed that 500 mg of the prescription significantly increased the abundances of the Succiniclasticum and Prevotella genera and notably decreased the abundances of the Christensenellaceae_R-7_group, Muribaculaceae, UCG-005, Comamonas, and F082 genera (p < 0.05). …"

Table 2_Sijunzi San alleviates the negative energy balance in postpartum dairy cows by regulating rumen fermentation capacity.xls حسب Feifei Wang (195514)

"…The results revealed that 500 mg of the prescription significantly increased the abundances of the Succiniclasticum and Prevotella genera and notably decreased the abundances of the Christensenellaceae_R-7_group, Muribaculaceae, UCG-005, Comamonas, and F082 genera (p < 0.05). …"

Image 1_Sijunzi San alleviates the negative energy balance in postpartum dairy cows by regulating rumen fermentation capacity.jpeg حسب Feifei Wang (195514)

"…The results revealed that 500 mg of the prescription significantly increased the abundances of the Succiniclasticum and Prevotella genera and notably decreased the abundances of the Christensenellaceae_R-7_group, Muribaculaceae, UCG-005, Comamonas, and F082 genera (p < 0.05). …"

Table 3_Sijunzi San alleviates the negative energy balance in postpartum dairy cows by regulating rumen fermentation capacity.xls حسب Feifei Wang (195514)

"…The results revealed that 500 mg of the prescription significantly increased the abundances of the Succiniclasticum and Prevotella genera and notably decreased the abundances of the Christensenellaceae_R-7_group, Muribaculaceae, UCG-005, Comamonas, and F082 genera (p < 0.05). …"

Focus group guide. حسب Judite Blanc (22559981)

"…<div><p>Amid the dismantling of state structures in Haiti, the first Black republic faces significant health disparities compared to its former colonial power, France. …"

Table 2_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.docx حسب Rui Jiang (264894)

"…Introduction<p>Rheumatoid arthritis (RA) is an autoimmune disorder characterized by significant disability and teratogenic effects, for which there are few effective curative therapies. …"