Search alternatives:
significant different » significantly different (Expand Search), significant difference (Expand Search), significant differences (Expand Search)
significant step » significant sex (Expand Search), significant gap (Expand Search), significant group (Expand Search)
different degree » different degrees (Expand Search), different age (Expand Search), different doses (Expand Search)
step decrease » sizes decrease (Expand Search), teer decrease (Expand Search), we decrease (Expand Search)
significant different » significantly different (Expand Search), significant difference (Expand Search), significant differences (Expand Search)
significant step » significant sex (Expand Search), significant gap (Expand Search), significant group (Expand Search)
different degree » different degrees (Expand Search), different age (Expand Search), different doses (Expand Search)
step decrease » sizes decrease (Expand Search), teer decrease (Expand Search), we decrease (Expand Search)
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Role of Chain Length and Degree of Unsaturation of Fatty Acids in the Physicochemical and Pharmacological Behavior of Drug–Fatty Acid Conjugates in Diabetes
Published 2021“…Several drug–fatty acid (FA) prodrugs have been reported to exhibit desirable physicochemical and pharmacological profile; however, comparative beneficial effects rendered by different FAs have not been explored. In the present study, four different FAs (linoleic acid, oleic acid, palmitic acid, and α-lipoic acid) were selected based on their chain length and degree of unsaturation and conjugated to Lisofylline (LSF), an antidiabetic molecule to obtain different drug–FA prodrugs and characterized for molecular weight, hydrophobicity, purity, self-assembly, and efficacy <i>in vitro</i> and <i>in vivo</i> in type 1 diabetes model. …”
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Coupling coordination degree classification.
Published 2025“…Secondly, the coupling coordination degree has shown a collective improvement, albeit with variations in coordination levels among different regions; however, the regional disparities are gradually narrowing. …”
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