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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Detection of statistically significant network changes in complex biological networks
منشور في 2017"…</p><h3>Methods</h3><p dir="ltr">In this paper, we propose an improvement over the state-of-the-art based on the Generalized Hamming Distance adopted for evaluating the topological difference between two networks and estimating its statistical significance. …"
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A genetic-based fuzzy logic power system stabilizer formultimachine power systems
منشور في 1997"…This paper presents a novel approach to combine genetic algorithms (GA) with fuzzy logic systems to design a genetic-based fuzzy logic power system stabilizer (GFLPSS) for multimachine power systems. …"
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Hybridizing rule-based power system stabilizers with geneticalgorithms
منشور في 1999"…A hybrid genetic rule-based power system stabilizer (GRBPSS) is presented in this paper. …"
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Learning-Based Spectrum Sensing and Access for Cognitive Radio Systems
منشور في 2015احصل على النص الكامل
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Reinforcement Learning Based EV Charging Management Systems–A Review
منشور في 2021"…Unlike other machine learning approaches, the RL technique is based on maximizing the cumulative reward. This article reviews the existing literature related to the RL-based framework, objectives, and architecture for the charging coordination strategies of electric vehicles in the power systems. …"
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Model Based Adaptive Tracking Scheme For Unknown MIMO Bilinear Systems
منشور في 2020"…Bilinear systems are attractive candidates for many dynamical processes, since they allow a significantly larger class of behaviour than linear systems, yet retain a rich theory which is closely related to the familiar theory of linear systems. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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Students’ perceptions of Kahoot!: An exploratory mixed-method study in EFL undergraduate classrooms in the UAE
منشور في 2021"…In recent years, game-based student response systems (GSRS) such as Socrative, Quizlet, and Kahoot! …"
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