-
1
A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
-
2
-
3
-
4
Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
-
5
-
6
Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
-
7
The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
-
8
-
9
Significance of Avicennia Marina in the Arabian Gulf Environment: A Review
Published 2025“…This review addresses the current knowledge gap by providing an overview of Avicennia marina distribution in the Gulf, exploring the significance of its ecosystem services, analyzing the impacts of stressors, and examining conservation and restoration efforts, with attention to nature-based and biotechnological approaches for promoting mangrove growth and conservation in the Gulf.…”
-
10
Detection of statistically significant network changes in complex biological networks
Published 2017“…The proposed procedure exploits a more effective model selection criteria to generate <i>p</i>-values for statistical significance and is more efficient in terms of computational time and prediction accuracy than literature methods. …”
-
11
-
12
-
13
A Diffusion-Based Probabilistic Ultra-Short-Term Solar Power Prediction Using the Sky Image Sequences
Published 2025“…Accurate ultra-short-term PhotoVoltaic (PV) power forecasting is crucial for the efficient and reliable operation of these energy systems. …”
-
14
Swimming exercise improves short‐ and long‐term memories: Time‐course changes
Published 2021“…Young adult Wistar rats were tested for both short-term and long-term memories using the radial arm water maize (RAWM) paradigm following 0, 1, 7, 14, and 28 days of swimming exercise training (60 min per day, 5 days/week)s. …”
-
15
-
16
A Novel Steganography Technique for Digital Images Using the Least Significant Bit Substitution Method
Published 2022“…Therefore, the proposed work, in this paper, is based on the Least Significant Bit (LSB) substitution method. …”
-
17
Supervised term-category feature weighting for improved text classification
Published 2022“…In this study, we provide a novel text classification framework for Category-based Feature Engineering titled CFE. It consists of a supervised weighting scheme defined based on a variant of the TF-ICF (Term Frequency-Inverse Category Frequency) model, embedded into three new lean classification approaches: (i) IterativeAdditive (flat), (ii) GradientDescentANN (1-layered), and (iii) FeedForwardANN (2-layered). …”
Get full text
Get full text
Get full text
Get full text
article -
18
-
19
Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
-
20
Exploring clinical leadership in long‐term care: An integrative literature review
Published 2021“…All selected articles were quality appraised using the Critical Appraisal Skills Program and the accuracy, authority, coverage, objectivity, date and significance checklist.</p> <h3> Key Issues</h3> <p>The analysis resulted in four themes: ambiguous definitions, practice-based and value-driven care, the impact of clinical leadership and clinical leadership development for Canadian nurses.…”
