Data Sheet 1_Comprehensive metagenomic and lipidomic analysis showed that baicalin could improve depressive behaviour in atherosclerotic mice by inhibiting nerve cell ferroptosis.z... حسب Peng Ren (337555)

"…Metabolic pathway enrichment analysis showed that differential lipid PEs were significantly enriched in the iron death pathway, and our further in vitro cellular experiments showed that baicalin could inhibit Erastin-induced Ferroptosis in the hippocampal neuronal cell line HT-22 by promoting the expression of SLC7A11, GSH, and GPX4, inhibiting the expression of ACSL4, and decreasing the cellular ROS.…"

Image1_Characterization of GABAergic marker expression in prefrontal cortex in dexamethasone induced depression/anxiety model.jpeg حسب Ling Hu (374570)

"…Background<p>The pivotal responsibility of GABAergic interneurons is inhibitory neurotransmission; in this way, their significance lies in regulating the maintenance of excitation/inhibition (E/I) balance in cortical circuits. …"

Table 1_NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), and SII (systemic immune-inflammation index) reflect disease activity and renal remission in patie... حسب Xiaohui Zhang (81778)

"…During the 12-month follow-up of induction therapy, NLR and PLR showed a decreasing trend. Both baseline NLR and SII were positively correlated with baseline UTP and serum creatinine (SCr) levels (r = 0.112-0.148, p< 0.05 for all). …"

Figure 6 from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes حسب Laura Kuett (20493991)

"…<b>F</b> and <b>G,</b> Immune cell phenotypic cluster enrichment in each clinical breast cancer subtype (<b>F</b>) or metastasis-defined patient group (<b>G</b>) at metastatic sites compared with average metastasis composition by differential abundance testing. Circles display significantly enriched (red) or decreased (blue; FDR < 0.05; multiple testing correction with the Benjamin–Hochberg method) results, with size indicating the log-transformed fold change.  …"

Supplementary file 1_Single-cell and bulk transcriptomic analyses reveal PANoptosis-associated immune dysregulation of fibroblasts in periodontitis.zip حسب Erli Wu (17785482)

"…</p>Results<p>scRNA-seq analysis revealed a decreased proportion of HGFs alongside enrichment of multiple PANoptosis-related pathways in PD samples. …"

<i>Salmonella </i>Typhimurium <i>StiP</i>-mediated upregulation of membrane protein Alx drives complement evasion via CFI-dependent C3b degradation حسب jin guan (21792620)

"…We further explored the role of <i>StiP</i> in host blood environment adaptation and found that 263<i>ΔStiP</i> displayed 3.12-fold reduced HeLa cell adhesion, 3.74-fold lower HeLa cell invasion, 1.92-fold decreased intra-macrophage survival, and 50% reduced serum resistance versus wild-type 263 (WT263), collectively indicating that <i>StiP</i> is critical for host blood environment adaptation in invasive <i>S</i>. …"

Glucagon-like peptide-1 receptor agonists, inflammation, and kidney diseases: evidence from Mendelian randomization حسب Yu-Xuan Yao (21338594)

"…</p> <p>After meta-analyses of both discovery and validation cohorts, genetically proxied GLP1R agonist was found to significantly associated with a decreased risk of diabetic nephropathy (OR = 0.72, 95%CI = 0.54–0.97, <i>p</i> = 0.031) and IgA nephropathy (OR = 0.58, 95%CI = 0.36–0.94, <i>p</i> = 0.027). …"

Data Sheet 1_Endophytic and antagonistic Bacillus amyloliquefaciens 8SE-IF1-derived nanoparticles encumber phytopathogenic oomycetes, fungi, bacteria, and viruses with enhanced gro... حسب A. Mary Sharmila (21898730)

"…The water-diffusible extract (WDE) of Ba-8SE-IF1 significantly inhibited the mycelial growth of Pythium aphanidermatum (44.6%), Phytophthora nicotianae (60.1%), Fusarium oxysporum f. sp. lycopersici (65.5%), and Colletotrichum gloeosporioides (66.7%) in poisoned food assays; the growth of Ralstonia solanacearum and Xanthomonas campestris in the agar well method (inhibition zones of 20.25 mm and 28.52 mm, respectively); and decreased the symptoms produced by tomato spotted wilt virus (TSWV) in local lesion host (68.3%) and tomato leaf curl New Delhi virus (ToLCNDV) in tomato plants (66.1%). …"

Image 4_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... حسب Chao Song (379006)

"…The most frequent grade 3–5 AEs in the PIBC group included anorexia (36.40%), decreased neutrophil count (16.25%), neutropenia (13.50%), reduced white blood cell count (12.12%), and febrile neutropenia (9.42%).…"

Table 3_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... حسب Chao Song (379006)

"…The most frequent grade 3–5 AEs in the PIBC group included anorexia (36.40%), decreased neutrophil count (16.25%), neutropenia (13.50%), reduced white blood cell count (12.12%), and febrile neutropenia (9.42%).…"

Supplementary data: Characterization of medical device randomized controlled trials with adaptive designs حسب Gui Su (128698)

"…The average annual number of adaptive RCTs per 1000 clinical trials was the highest (8.55 ± 11.65) during 2005–2010, reduced to 3.33 ± 2.35 during 2011–2016, and significantly decreased to 1.29 ± 0.85 during 2017–2024 (p = 0.011). …"

Table 1_Association of SPP1 and NCAPG genes with milk production traits in Chinese Holstein cows: polymorphism and functional validation analysis.xlsx حسب Chuanchuan Wang (12228518)

"…Association analysis showed that all six SNPs were significantly associated with milk protein percentage. …"

Table 6_Association of SPP1 and NCAPG genes with milk production traits in Chinese Holstein cows: polymorphism and functional validation analysis.xlsx حسب Chuanchuan Wang (12228518)

"…Association analysis showed that all six SNPs were significantly associated with milk protein percentage. …"

Data Sheet 2_A Delphi-based framework for optimizing nurse staffing in Chinese hospitals.docx حسب Waner Wang (17773704)

"…The primary objectives of this optimization process include reducing nurse workload, improving job satisfaction, and decreasing turnover rates, all of which facilitate improved patient outcomes.…"

Image 2_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... حسب Chao Song (379006)

"…The most frequent grade 3–5 AEs in the PIBC group included anorexia (36.40%), decreased neutrophil count (16.25%), neutropenia (13.50%), reduced white blood cell count (12.12%), and febrile neutropenia (9.42%).…"

Data Sheet 1_A Delphi-based framework for optimizing nurse staffing in Chinese hospitals.pdf حسب Waner Wang (17773704)

"…The primary objectives of this optimization process include reducing nurse workload, improving job satisfaction, and decreasing turnover rates, all of which facilitate improved patient outcomes.…"

Table 7_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... حسب Chao Song (379006)

"…The most frequent grade 3–5 AEs in the PIBC group included anorexia (36.40%), decreased neutrophil count (16.25%), neutropenia (13.50%), reduced white blood cell count (12.12%), and febrile neutropenia (9.42%).…"

Maresin-1 alleviates sepsis-induced acute kidney injury by inhibiting ferroptosis via the Nrf2/HO-1/Gpx4 signaling pathway حسب Lili Tang (23345)

"…In the mouse model, MaR-1 administration decreased renal injury markers (BUN, SCr, NGAL) and ferroptosis-related indicators in kidney tissues. …"

Image1_Protective effects of YCHD on the autoimmune hepatitis mice model induced by Ad-CYP2D6 through modulating the Th1/Treg ratio and intestinal flora.tif حسب Jiawen Wu (63886)

"…The degree of inflammatory infiltration in the YCHD-treated group was significantly less than that in the untreated group. …"

Supplementary Material for: Leveraging NLP for Psychiatric Phenotyping from Spanish EHR: Enabling the Investigation of Transdiagnostic Symptom Profiles at Scale حسب figshare admin karger (2628495)

"…The COMBINED algorithm improved overall recall, without significantly decreasing precision (F1 of 0.78 and 0.77 on HOMO and CSJDM, respectively). …"