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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …"
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Microalgal-based desalination brine remediation: Achievements, challenges, and future research trends
منشور في 2024"…In addition, desalination plants consume significant amounts of energy, which contribute to carbon emissions and global warming. …"
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Artificial intelligence based anomaly detection of energy consumption in buildings: A review, current trends and new perspectives
منشور في 2021"…Following, insights about current research trends are discussed to widen the applications and effectiveness of the anomaly detection technology before deriving future directions attracting significant attention. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Current trends in hospital pharmacy practice in Lebanon
منشور في 2019"…Although not statistically significant, there was a higher trend toward having a designated champion for medication safety (P = .052). …"
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Trends in Necrotizing Fasciitis‐Associated Mortality in the United States 2003–2020: A CDC WONDER Database Population‐Based Study
منشور في 2025"…</p><h3>Conclusions</h3><p dir="ltr">NF‐related mortality has significantly risen in the United States since 2014, with distinct disparities based on sex, race, and geographic region. …"
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Hemodynamics of small aneurysm pairs at the internal carotid artery
منشور في 2012"…The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. Interaction between parallel aneurysms is not significant; however, the proximal aneurysm in serial aneurysms may be subject to a greater rupture risk.…"
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
منشور في 2006احصل على النص الكامل
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Real estate market trends in the first new urbanist town: seaside, Florida
منشور في 2022"…Four decades provides a significant sample size to investigate sale price trends and fluctuations in single-family residential homes in Seaside. …"
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A Multidecadal Assessment of Haze Development and Fluctuations in Visibility for Arabian Peninsula
منشور في 2024"…To comprehend the time-based patterns of visibility across the ME, we utilized the Mann Kendall (MK) and Modified Mann Kendall (MMK) trend estimators in both space and time. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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