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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Analysis of mode choice affects from the introduction of Doha Metro using machine learning and statistical analysis
Published 2023“…The results showed that various trip characteristics are significant in determining the mode choice, including the number of travelers and bags, journey time, and reimbursement of parking fees. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Analysis of mode choice affects from the introduction of Doha Metro using machine learning and statistical analysis
Published 2023“…The results showed that various trip characteristics are significant in determining the mode choice, including the number of travelers and bags, journey time, and reimbursement of parking fees. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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NOVEL STACKING CLASSIFICATION AND PREDICTION ALGORITHM BASED AMBIENT ASSISTED LIVING FOR ELDERLY
Published 2022“…Therefore, this thesis proposed a Novel Stacking Classification and Prediction (NSCP) algorithm based on AAL for the older people with Multi-strategy Combination based Feature Selection (MCFS) and Novel Clustering Aggregation (NCA) algorithms. …”
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Blue collar laborers’ travel pattern recognition: Machine learning classifier approach
Published 2021“…The study results show significant diversity amongst the clusters in terms of trip purpose, modal split, destination choice, and occupation. …”
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Data-Driven Electricity Demand Modeling for Electric Vehicles Using Machine Learning
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Shared Clean Mobility Operations for First-Mile and Last-Mile Public Transit Connections: A Case Study of Doha, Qatar
Published 2022“…Moreover, adding the carpooling option can significantly decrease the number of relocations operations at a minimal impact on the commuters’ trip performance.…”
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Planning for Congestion Pricing Policies in the Middle East: Public Acceptability and Revenue Distribution
Published 2020“…The results indicated that trip conditions (travel speed, travel distance, and trip urgency); respondents’ age, income, employment status, and car ownership; and toll fees are significant factors in determining public acceptability of HOT lanes, while respondents’ average monthly income, age, employment status, car ownership, and saving in travel time are significant factors of determining public acceptability of cordon pricing.…”