A novel inhibitor of STAT3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells by Abou-Ghazal, Mohamed K.

“…Although WP1066 did not induce immunological memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (TGF-β, RANTES, MCP-1, VEGF), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …”
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Neuronal BST2: A Pruritic Mediator alongside Protease-Activated Receptor 2 in the IL-27–Driven Itch Pathway by Yanqing, Li

“…Although IL-27 is linked to AD, its role and clinical significance in itch remain undefined. We sought to investigate IL-27 function in itch using tissue-specific transgenic mice, various itch models, behavior scoring, RNA sequencing, and cytokine/kinase array. …”
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A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T ce... by Abou-Ghazal, Mohamed

“…Although WP1066 did not induce immunologic memory or enhance humoral responses to EGFRvIII, this compound reduced the production of immunosuppressive cytokines and chemokines (transforming growth factor-β, RANTES, MCP-1, vascular endothelial growth factor), markedly inhibited natural and inducible Treg proliferation, and significantly increased cytotoxic immune responses of T cells. …”
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Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation by Shilpa Kuttikrishnan (3520079)

“…Prist significantly increases reactive oxygen species (ROS) levels and depletes glutathione (GSH), leading to mitochondrial dysfunction and cytochrome c release. …”

Ultrasonically Triggered Release of Folic Acid-Conjugated Liposomes for Breast Cancer Therapy Within Microfluidic Devices by AlHazaimeh, Taima Khair Alla

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Profiling the autoantibody repertoire reveals autoantibodies associated with mild cognitive impairment and dementia by Hanan Ehtewish (17149825)

“…</p><h3>Conclusion</h3><p dir="ltr">We have shown multiple dysregulated autoantibodies in the plasma of subjects with MCI and dementia. …”

Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity by Mohamed Abu-Farha (18535590)

“…In functional assays, our data indicated that ectopic expression of HDAC4 significantly impaired TNF-α-dependent activation of NF-κB, establishing thus a link between HDAC4 and regulation of the immune system. …”

Deep Learning for the Accurate Prediction of Triggered Drug Delivery by Husseini, Ghaleb

“…The deep learning-based predictions significantly outperform linear predictions, proving the utility of advanced computational methods in drug delivery. …”
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Effect of national culture on the design of management control systems of multinational enterprises by Elgammal, Walid

“…This kind of research has gained increasing prominence, as it is important to the business community. …”
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Whole-genome Sequences of Multidrug-Resistant Escherichia coli by Khodor, Ragheed R.

“…In this study, we performed a whole-genome sequence-based analysis to understand the molecular epidemiology of multidrug-resistant E. coli clinical isolates. …”
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Brucellosis in older person: a case report from Qatar by Hanadi Khamis Al Hamad (21406964)

“…However, atypical clinical presentation and lack of specific history taking can delay diagnosis and treatment; it leads to serious clinical disease progression with increased complications. From this case study, we would contribute to optimal assessment and to keep differential diagnosis for unknown cause of fever can be Brucellosis in geriatric population.…”

The outcome of severe traumatic brain injury in children in Qatar: Six-year study by Azhar Khattab (19774476)

“…Finally, the incidence of TBIs from road traffic crashes and injuries in Qatar are increasing significantly compared to other developing and developed countries. …”

revisiting credit risk assessment of SMEs by Serov, Vasiliy

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Theoretical insight into effect of cation–anion pairs on CO₂ reduction on bismuth electrocatalysts by Sun Hee Yoon (7179263)

“…The adsorption energy (Eads) and work function (Wf) of the anions increases with decreasing anion size (i.e., Cl⁻ > Br⁻ > I⁻). …”

Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer by Sampath, Lakshmi

“…Results: (DTPA)n-trastuzumab-(IRDye800)m showed significantly greater binding to SKBr3 cells than to MDA-MB-231 cells. …”
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VisioDECT: a novel approach to drone detection using CBAM-integrated YOLO and GELAN-E models by Md. Sakib Bin Islam (22828181)

“…Additionally, we employ Gradient-weighted Class Activation Mapping (EigenCAM) for visualizing model focus during detection, increasing the system’s transparency and interpretability. …”

Anterior ankle impingment syndrome is less frequent, but associated with a longer absence and higher re-injury rate compared to posterior syndrome: a prospective cohort study of 67... by Pieter D’Hooghe (3530984)

“…</p><h3>Methods</h3><p dir="ltr">Between the 2001–2002 and 2018–2019 seasons, 120 European soccer teams were followed prospectively for various seasons. …”

MicroRNA Expression Profiling on Paired Primary and Lymph Node Metastatic Breast Cancer Revealed Distinct microRNA Profile Associated With LNM by Ramesh Elango (7542068)

“…BC patients are oftentimes presented with lymph node metastasis (LNM), which increases their risk of recurrence. Compelling data have recently implicated microRNAs in promoting BC metastasis. …”

Burden of Transport-Related Injuries in the Eastern Mediterranean Region: A Systematic Analysis for the Global Burden of Disease Study 2017 by Saeid Safiri (3713035)

“…</p><h3>Results</h3><p dir="ltr">In 2017, there were 5.5 million (UI 4.9–6.2) transport-related incident cases in the EMR – a substantial increase from 1990 (2.8 million; UI 2.5–3.1). The age-standardized incidence rate for the EMR in 2017 was 787 (UI 705.5–876.2) per 100000,which has not changed significantly since 1990 (-0.9%; UI -4.7 to 3). …”