Search alternatives:
significant hits » significant units (Expand Search), significant bias (Expand Search), significant anti (Expand Search)
teer decrease » mean decrease (Expand Search), greater decrease (Expand Search)
hits increase » units increased (Expand Search), bias increases (Expand Search), unit increase (Expand Search)
significant hits » significant units (Expand Search), significant bias (Expand Search), significant anti (Expand Search)
teer decrease » mean decrease (Expand Search), greater decrease (Expand Search)
hits increase » units increased (Expand Search), bias increases (Expand Search), unit increase (Expand Search)
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Y-27632 collaborated with BA to attenuate the increase in the integrity and decrease in the permeability of epithelial barrier injury induced by LPS in Caco2 monolayers.
Published 2024“…<p>(<b>A)</b> Y-27632 collaborated with BA to attenuate the effect of LPS on TEER in Caco2 cells on days 1–22. (<b>B)</b> Y-27632 collaborated with BA to attenuate the effect of LPS on TEER in Caco2 cells on day 22. …”
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Validation of primary screen hits reveals compounds that recapitulate increased spheroid size (swell) or decreased MUC5AC in the lumen.
Published 2023“…Compounds that appeared to cause toxicity were identified by observing a significant decrease in spheroid counts in the swell readout or a significant decrease in the total nuclear intensity of the MUC5AC ratio readout. …”
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Bootstrapped LIWC negative word ratio (LWNR) around the hit date for each hurricane and location.
Published 2022Subjects: -
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Transepithelial electrical resistance (TEER) (N = 6).
Published 2024“…<p><b>(A)</b> During the cultivation of SMC and ALI we observed significantly differences on day 18 (SMC: 9.61 kΩ*cm<sup>2</sup>; ALI: 7.73 kΩ*cm<sup>2</sup>; p<0.05) and day 25 (SMC: 8.19 kΩ*cm<sup>2</sup>; ALI: 6.44 kΩ*cm<sup>2</sup>; p<0.05) ALI cultures showed significantly decreased values compared to SMC. …”
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Spheroid size changes due to primary mucus reduction hits and mucus changes due to primary swell hits.
Published 2023“…Compounds 56 (1μM), 85 (10μM), and 294 (1 and 10μM) significantly increased MUC5AC ratio compared to DMSO + CSE 3% control and were therefore filtered out of swell hit selection. …”
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