Showing 18,461 - 18,480 results of 21,342 for search '(( significantly ((affect decrease) OR (largest decrease)) ) OR ( significant decrease decrease ))', query time: 0.59s Refine Results
  1. 18461
  2. 18462
  3. 18463

    Table 1_Targeting nail psoriasis: IL-17A inhibitors demonstrate site-specific superiority over IL-23 inhibitor in a 24-week dermoscopy-guided real-world cohort.docx by Xiamei Yan (21014921)

    Published 2025
    “…</p>Results<p>(1) By week 24, PASI, BSA, DLQI and NAPSI scores had significantly decreased from baseline in all groups (P<0.001). (2) By week 24: SEC, IXE, and GUS groups saw nail matrix NAPSI score improvements of 65.9%, 60.5%, and 51.5%, with 68%, 55%, and 30% achieving NAPSI 60; Nail bed NAPSI score improvements were 58.8%, 68.6%, and 65.8%, with 28%, 65%, and 40% achieving NAPSI 60; Total NAPSI score improvements were 62.7%, 64.6%, and 53.7%, with 44%, 70%, and 30% achieving NAPSI 60. (3) All patients in the SEC and IXE groups achieved PASI 75, compared to 85% in the GUS group. …”
  4. 18464
  5. 18465

    Table11_Unveiling the molecular landscape of PCOS: identifying hub genes and causal relationships through bioinformatics and Mendelian randomization.xlsx by Yifang He (18126257)

    Published 2024
    “…</p>Conclusions<p>Our bioinformatics combined with MR analysis revealed that CD93, CYBB, DOCK8, IRF1, MBOAT1, MYO1F, NLRP1, NOD2, PIK3R1 increase the risk of PCOS, while PTER decreases the risk of PCOS. This discovery has implications for clinical decision-making in terms of disease diagnosis, prognosis, treatment strategies, and opens up novel avenues for drug development.…”
  6. 18466

    Data Sheet 1_Cross-species analysis of FcγRIIa/b (CD32a/b) polymorphisms at position 131: structural and functional insights into the mechanism of IgG- mediated phagocytosis in hum... by William D. Tolbert (7870697)

    Published 2025
    “…In contrast, allele-specific effects in macaques were highly significant; the macaque P<sup>131</sup> variant showing uniformly reduced IgG affinity. …”
  7. 18467

    Table 1_Kidney sparing surgery versus radical nephroureterectomy in upper tract urothelial carcinoma: a meta-analysis and systematic review.docx by Leqing Zhou (20981021)

    Published 2025
    “…In the comparison between the endoscopic management (EM) and RNU groups, EM was associated with worse overall survival outcomes (HR,1.40; 95%CI,1.08-1.82; P=0.01) based on multivariable Cox regression analysis, and the upper tract recurrence rate (OR,39.06; 95%CI, 14.55-104.85; P<0.00001) was significantly higher in the EM group. On the other hand, in patients treated with KSS, postoperative renal function as measured by eGFR increased by 0.4ml/min/1.73 m<sup>2</sup>, while it decreased by 11.4ml/min/1.73 m<sup>2</sup> in the RNU group (WMD, 11.81 ml/min/1.73 m<sup>2</sup>; 95%CI,9.06-14.56; P<0.0001).…”
  8. 18468

    DataSheet1_Erlotinib regulates short-term memory, tau/Aβ pathology, and astrogliosis in mouse models of AD.doc by Hyun-ju Lee (7550741)

    Published 2024
    “…Moreover, erlotinib treatment decreased astrogliosis in 6-month-old PS19 mice and reduced proinflammatory responses in primary astrocytes (PACs) from PS19 mice. …”
  9. 18469
  10. 18470

    Table 1_The knowledge paradox: an inverted U-shaped association between HIV knowledge and stigma among older men in Sichuan Province, Southwest China.docx by Zhihua Ye (3133311)

    Published 2025
    “…Background<p>Older men (≥50 years) in China face elevated HIV infection risks, yet HIV stigma remains a significant barrier to prevention. Although HIV knowledge is frequently assumed to reduce stigma, the evidence is inconsistent. …”
  11. 18471

    Data Sheet 1_Metformin upregulates circadian gene PER2 to inhibit growth and enhance the sensitivity of glioblastoma cell lines to radiotherapy via SIRT2/G6PD pathway.docx by Hailiang Li (740080)

    Published 2025
    “…Meanwhile, NADPH+ production and G6PDH enzyme activity significantly decreased. Further study validated that metformin inhibited the cell growth of GBM cell lines through up-regulating PER2 and inhibited SIRT2/G6PD signaling pathway, enhancing radiotherapy(RT) sensitivity. …”
  12. 18472

    Table8_Unveiling the molecular landscape of PCOS: identifying hub genes and causal relationships through bioinformatics and Mendelian randomization.xlsx by Yifang He (18126257)

    Published 2024
    “…</p>Conclusions<p>Our bioinformatics combined with MR analysis revealed that CD93, CYBB, DOCK8, IRF1, MBOAT1, MYO1F, NLRP1, NOD2, PIK3R1 increase the risk of PCOS, while PTER decreases the risk of PCOS. This discovery has implications for clinical decision-making in terms of disease diagnosis, prognosis, treatment strategies, and opens up novel avenues for drug development.…”
  13. 18473
  14. 18474

    Table5_Unveiling the molecular landscape of PCOS: identifying hub genes and causal relationships through bioinformatics and Mendelian randomization.xlsx by Yifang He (18126257)

    Published 2024
    “…</p>Conclusions<p>Our bioinformatics combined with MR analysis revealed that CD93, CYBB, DOCK8, IRF1, MBOAT1, MYO1F, NLRP1, NOD2, PIK3R1 increase the risk of PCOS, while PTER decreases the risk of PCOS. This discovery has implications for clinical decision-making in terms of disease diagnosis, prognosis, treatment strategies, and opens up novel avenues for drug development.…”
  15. 18475

    DataSheet1_Probiotics combined with prebiotics alleviated seasonal allergic rhinitis by altering the composition and metabolic function of intestinal microbiota: a prospective, ran... by Yangfan Hou (8043884)

    Published 2024
    “…From baseline to day 91, mean difference between groups (MDBG) in the reduction of TNSS was -1.1 (-2.2, -0.1) (P = 0.04); MDBG in the increment of TNF-α was 7.1 pg/ml (95% CI: 0.8, 13.4, P = 0.03); the INF-γ level was significantly increased (P = 0.01), whereas that of IL-17 (P = 0.005) was significantly decreased in the test group, whilst mean difference within groups was not statistically significant in the placebo group; MDBG in the increment of acetate was 12.4% (95% CI: 7.1%, 17.6%, P <0.001). …”
  16. 18476

    Table 1_Evaluating the Implementation of fan-beam CT-guided online adaptive re-planning in definitive cervical cancer radiotherapy.docx by Shuai Sun (775057)

    Published 2025
    “…This approach has shown significant improvements in dose distribution and the potential to provide clinical benefits by reducing acute toxicity.…”
  17. 18477

    Experimental protocol and behavioral evidence of perceptual learning. by Sarit F.A. Szpiro (21094755)

    Published 2025
    “…The shaded area represents the standard error of the mean. Significant clusters for the main effect of PRE/post training, as determined by cluster mass permutation two-tailed tests, are indicated with rectangles (p < 0.05 and p < 0.1). …”
  18. 18478

    Care quality. by Youssef Hbid (18803761)

    Published 2025
    “…<div><p>Background and aim</p><p>The COVID-19 pandemic imposed significant pressures on healthcare services such as stroke care. …”
  19. 18479
  20. 18480

    Image 1_Kidney sparing surgery versus radical nephroureterectomy in upper tract urothelial carcinoma: a meta-analysis and systematic review.tif by Leqing Zhou (20981021)

    Published 2025
    “…In the comparison between the endoscopic management (EM) and RNU groups, EM was associated with worse overall survival outcomes (HR,1.40; 95%CI,1.08-1.82; P=0.01) based on multivariable Cox regression analysis, and the upper tract recurrence rate (OR,39.06; 95%CI, 14.55-104.85; P<0.00001) was significantly higher in the EM group. On the other hand, in patients treated with KSS, postoperative renal function as measured by eGFR increased by 0.4ml/min/1.73 m<sup>2</sup>, while it decreased by 11.4ml/min/1.73 m<sup>2</sup> in the RNU group (WMD, 11.81 ml/min/1.73 m<sup>2</sup>; 95%CI,9.06-14.56; P<0.0001).…”