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significant effect » significant impact (Expand Search)
altered decrease » altered release (Expand Search), observed decrease (Expand Search)
effect decrease » effects decreased (Expand Search)
teer decrease » mean decrease (Expand Search), greater decrease (Expand Search)
significant effect » significant impact (Expand Search)
altered decrease » altered release (Expand Search), observed decrease (Expand Search)
effect decrease » effects decreased (Expand Search)
teer decrease » mean decrease (Expand Search), greater decrease (Expand Search)
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11421
Image 6_Establishment and validation of survival nomogram score staging for esophageal squamous cell carcinoma patients after minimally invasive surgery combined with immune progno...
Published 2025“…The dynamic mortality risk rate revealed a double peak in the high-risk patients (12 and 48 months) and a single peak in the low–risk patients (24 months) and middle-risk patients (12 months), which gradually decreased over time.</p>Conclusion<p>The SNS staging based on IPI and clinicopathological features can thus be applied to effectively evaluate the OS and DFS of ESCC patients after MIE. …”
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11422
Image 1_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.tif
Published 2025“…</p>Discussion<p>Our study reveals that the RMRM risk model could effectively predict the prognosis of HCC, and SPP1<sup>+</sup> macrophages regulated by miR-4739-RNA methylation promote the proliferation and migration of HCC cells. …”
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11423
Image 2_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.tif
Published 2025“…Furthermore, univariate and multivariate Cox analysis were used to assess the prognostic effects of ARPs. The investigation of immune cell infiltration and possible functional enrichment followed. …”
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11424
Table 2_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.xlsx
Published 2025“…</p>Discussion<p>Our study reveals that the RMRM risk model could effectively predict the prognosis of HCC, and SPP1<sup>+</sup> macrophages regulated by miR-4739-RNA methylation promote the proliferation and migration of HCC cells. …”
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11425
Image 3_Establishment and validation of survival nomogram score staging for esophageal squamous cell carcinoma patients after minimally invasive surgery combined with immune progno...
Published 2025“…The dynamic mortality risk rate revealed a double peak in the high-risk patients (12 and 48 months) and a single peak in the low–risk patients (24 months) and middle-risk patients (12 months), which gradually decreased over time.</p>Conclusion<p>The SNS staging based on IPI and clinicopathological features can thus be applied to effectively evaluate the OS and DFS of ESCC patients after MIE. …”
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11426
Image 4_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.tif
Published 2025“…</p>Discussion<p>Our study reveals that the RMRM risk model could effectively predict the prognosis of HCC, and SPP1<sup>+</sup> macrophages regulated by miR-4739-RNA methylation promote the proliferation and migration of HCC cells. …”
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11427
Table 1_NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), and SII (systemic immune-inflammation index) reflect disease activity and renal remission in patie...
Published 2025“…NLR, PLR and SII provided us a quick, simple and cost-effective supervision way in monitoring and managing LN patients.…”
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11428
Table 1_Single-cell and spatial transcriptomics reveal correlation between RNA methylation-related miRNA risk model and immune infiltration in hepatocellular carcinoma.xlsx
Published 2025“…</p>Discussion<p>Our study reveals that the RMRM risk model could effectively predict the prognosis of HCC, and SPP1<sup>+</sup> macrophages regulated by miR-4739-RNA methylation promote the proliferation and migration of HCC cells. …”
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11429
Table 1_Expression, prognosis and preliminary investigation of the mechanism of action of ACTR6, a member of the ARPs gene family, in hepatocellular carcinoma.docx
Published 2025“…Furthermore, univariate and multivariate Cox analysis were used to assess the prognostic effects of ARPs. The investigation of immune cell infiltration and possible functional enrichment followed. …”
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11430
Image 5_Establishment and validation of survival nomogram score staging for esophageal squamous cell carcinoma patients after minimally invasive surgery combined with immune progno...
Published 2025“…The dynamic mortality risk rate revealed a double peak in the high-risk patients (12 and 48 months) and a single peak in the low–risk patients (24 months) and middle-risk patients (12 months), which gradually decreased over time.</p>Conclusion<p>The SNS staging based on IPI and clinicopathological features can thus be applied to effectively evaluate the OS and DFS of ESCC patients after MIE. …”
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11431
SEAwise synthesis of predicted impacts of changes in habitat and spatial management measures suggested in SEAwise for online tool
Published 2025“…Such spatial conservation measures will induce negative short-term effects on the fisheries (e.g.: decreased catches and increased operating costs due to effort displacement to surrounding or distant areas) as well as potentially harmful counterproductive effects on biodiversity in some occurrences. …”
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11432
Data Sheet 1_Improved myocardial mitochondrial energy metabolism in rats with chronic heart failure by modifying fatty acid oxidation using an extract of sand-fired aconite (Jianch...
Published 2025“…</p>Results<p>SFAS significantly improved cardiac function in CHF rats. …”
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11433
Table 1_Determining the efficacy and safety of acupuncture for the treatment of menstrual migraine: an updated systematic review and meta-analysis.docx
Published 2025“…Compared with control interventions, acupuncture significantly reduced VAS scores, decreased the frequency and duration of migraine attacks, and improved response rates, as well as HIT-6 and MHI scores. …”
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11434
Image 1_Polygonatum sibiricum polysaccharides enhance pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway.tif
Published 2025“…Polygonatum sibiricum polysaccharides (PSP) have demonstrated potential anti-diabetic effects; however, their precise mechanism, particularly through the AMPK-SIRT1 pathway, remains unclear.…”
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11435
Table 1_Avoiding touching until 60 min—contamination of transdermal estradiol gel after physical contact.docx
Published 2025“…In the estradiol gel group, estradiol levels remained stable within the first 30 min (p >0.05), rapidly decreased at 60 min (p <0.001) and remained stable from 60 min to 120 min (p >0.05). …”
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11436
Image 4_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an...
Published 2025“…This meta-analysis aims to compare the antitumor effectiveness and safety profiles of PIBC with PIC.</p>Methods<p>We systematically searched six databases to identify eligible RCTs. …”
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11437
Table 3_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an...
Published 2025“…This meta-analysis aims to compare the antitumor effectiveness and safety profiles of PIBC with PIC.</p>Methods<p>We systematically searched six databases to identify eligible RCTs. …”
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11438
Supplementary data: Characterization of medical device randomized controlled trials with adaptive designs
Published 2024“…The average annual number of adaptive RCTs per 1000 clinical trials was the highest (8.55 ± 11.65) during 2005–2010, reduced to 3.33 ± 2.35 during 2011–2016, and significantly decreased to 1.29 ± 0.85 during 2017–2024 (p = 0.011). …”
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11439
Table 1_Association of SPP1 and NCAPG genes with milk production traits in Chinese Holstein cows: polymorphism and functional validation analysis.xlsx
Published 2024“…<p>Milk production traits play an important role in dairy cattle breeding, and single nucleotide polymorphisms can be used as effective molecular markers for milk production trait marker-assisted breeding in dairy cattle. …”
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11440
Image 4_The benefits and risks of adding PD-1/PD-L1 inhibitors to chemotherapy for stage IIIb-IV non-small-cell lung cancer: an updated meta-analysis based on phase 3 randomized co...
Published 2025“…Background<p>Previous research has confirmed that integrating PD-1/PD-L1 inhibitors with chemotherapy (PC) represents a more effective strategy for treating advanced non-small-cell lung cancer (NSCLC). …”