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    Data acquired from testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function by Janet Storm (8266991)

    Published 2020
    “…The authors used a co-culture of primary human brain microvascular endothelial cells (HBMEC) with <i>Plasmodium falciparum</i> material, recombinant PfEMP1 or lysates from infected erythrocytes (IE), and measured barrier function by Trans Endothelial Electrical Resistance (TEER). A selection of Protease-Activated Receptor-1 (PAR1) inhibitors was tested for their ability to reverse the <i>P. falciparum</i> and thrombin induced decrease in barrier function.…”
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