'Plan-B':  Impact of changes in the global funding landscape for Hepatitis B clinical and research programmes by marion delphin (13249479)

“…One-third of respondents reported already experiencing significant impact from funding changes, while over two-thirds expressed high concerns about future effects. …”

Video 3_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 by Lina Ouologuem (22489549)

“…These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…”

Table 1_Impact of short-term (24 h) blood pressure variability on 30-days clinical outcomes of acute strokes at two tertiary hospitals in Dar-es-Salaam.docx by Ayubu Eliesikia Mashambo (22596824)

“…Functional outcomes improved significantly by day 30: the Barthel Index increased, and mRS scores decreased. …”

Data Sheet 1_MIKC-type MADS-box transcription factor OsMADS31 positively regulates salinity tolerance in rice.pdf by Xiaolin Yin (359202)

“…Conversely, compared with WT plants, 3,3’-diaminobenzidine (DAB) and nitroblue tetrazolium (NBT) staining intensities as well as malondialdehyde (MDA) content were significantly higher in osmads31 mutants and significantly lower in OE lines. …”

Video 7_Loss of two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC.mp4 by Lina Ouologuem (22489549)

“…These metabolic and signalling alterations were associated with decreased tumour proliferation and increased MHC-I surface expression.…”

Table 1_Protocatechuic aldehyde ameliorates high glucose-induced podocyte injury by attenuating inflammation, oxidative stress, and apoptosis via suppression of endoplasmic reticul... by Yishu Wang (845334)

“…PCA significantly reduced the secretion of inflammatory cytokines (TNF-α, IL-1β, IL-6), restored the activities of SOD and GSH-Px, decreased MDA content, and downregulated the expression of Cox-2, iNOS, Nox2, and Nox4 proteins, thereby suppressing HG-induced podocyte inflammation and oxidative stress. …”

FLEXI interactions with RNA-binding proteins. by Jun Yao (9646)

“…RNA-binding sites: I, within introns corresponding to FLEXIs; SS-I and SS-E, bimodally enriched across the 5’- and 3’ splice sites in unspliced pre-mRNAs with the midpoints in the intron or flanking exon (SS-I and SS-E, respectively; Figs <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.g004" target="_blank">4A</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s011" target="_blank">S11</a>). mRNA levels, RBPs whose knockdown resulted in significant difference in mRNA levels (increased or decreased, DESeq2 |LFC|≥1, adjusted p≤0.05) from host gene of FLEXIs with a binding site for that RBP compared to those genes whose transcripts lacked a binding site for the same RBPs based on ENCODE RBP-knockdown datasets (p≤0.05 calculated by Fisher’s exact test; <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011416#pgen.1011416.s013" target="_blank">S13 Fig</a>). …”

Minimal test data set by Wenshun Sheng (21485393)

“…OSA is highly sensitive to information of different scales, and its one-time aggregation property substantially decreases the computational overhead of the model. …”

Data Sheet 1_Perceived benefits and barriers to the use of long-acting injectable antiretroviral treatment among adolescents and young people living with HIV in Western Kenya: qual... by Shukri A. Hassan (14245301)

“…Introduction<p>Adolescents and young people living with HIV (AYPLHIV) face significant hurdles in adhering to daily oral antiretroviral therapy (ART). …”

OSNet network structure. by Wenshun Sheng (21485393)

“…OSA is highly sensitive to information of different scales, and its one-time aggregation property substantially decreases the computational overhead of the model. …”

Data Sheet 2_Perceived benefits and barriers to the use of long-acting injectable antiretroviral treatment among adolescents and young people living with HIV in Western Kenya: qual... by Shukri A. Hassan (14245301)

“…Introduction<p>Adolescents and young people living with HIV (AYPLHIV) face significant hurdles in adhering to daily oral antiretroviral therapy (ART). …”

DataSheet_1_FCGR2/3 polymorphisms are associated with susceptibility to Kawasaki disease but do not predict intravenous immunoglobulin resistance and coronary artery aneurysms.docx by Paula Uittenbogaard (19691794)

“…Treatment with intravenous immunoglobulin (IVIg) significantly decreases the risk of CAA, possibly through competitive binding to Fc-gamma receptors (FcγRs), which reduces the binding of pathological immune complexes. …”

DataSheet1_Effects of mesenchymal stromal cells and human recombinant Nerve Growth Factor delivered by bioengineered human corneal lenticule on an innovative model of diabetic reti... by Letizia Pelusi (9606879)

“…In the last years, mesenchymal stromal cells (MSCs) and neurotrophins like Nerve Growth Factor (NGF), have garnered significant attention as innovative therapeutic approaches targeting DR-associated neurodegeneration. …”

YOLOv8 overall framework. by Wenshun Sheng (21485393)

“…OSA is highly sensitive to information of different scales, and its one-time aggregation property substantially decreases the computational overhead of the model. …”

The performance of YOFGD model on MOT16. by Wenshun Sheng (21485393)

“…OSA is highly sensitive to information of different scales, and its one-time aggregation property substantially decreases the computational overhead of the model. …”

Table 1_Targeting nail psoriasis: IL-17A inhibitors demonstrate site-specific superiority over IL-23 inhibitor in a 24-week dermoscopy-guided real-world cohort.docx by Xiamei Yan (21014921)

“…</p>Results<p>(1) By week 24, PASI, BSA, DLQI and NAPSI scores had significantly decreased from baseline in all groups (P<0.001). (2) By week 24: SEC, IXE, and GUS groups saw nail matrix NAPSI score improvements of 65.9%, 60.5%, and 51.5%, with 68%, 55%, and 30% achieving NAPSI 60; Nail bed NAPSI score improvements were 58.8%, 68.6%, and 65.8%, with 28%, 65%, and 40% achieving NAPSI 60; Total NAPSI score improvements were 62.7%, 64.6%, and 53.7%, with 44%, 70%, and 30% achieving NAPSI 60. (3) All patients in the SEC and IXE groups achieved PASI 75, compared to 85% in the GUS group. …”

Table1_Adverse event signal mining and severe adverse event influencing factor analysis of Lumateperone based on FAERS database.docx by Yanjing Zhang (401134)

“…Conversely, concomitant use of CYP3A4 inhibitors or drugs metabolized by CYP3A4 was associated with a decreased risk of severe AEs (OR = 0.524 [0.434, 0.633], P = 0.000).…”

Data Sheet 1_Cross-species analysis of FcγRIIa/b (CD32a/b) polymorphisms at position 131: structural and functional insights into the mechanism of IgG- mediated phagocytosis in hum... by William D. Tolbert (7870697)

“…In contrast, allele-specific effects in macaques were highly significant; the macaque P¹³¹ variant showing uniformly reduced IgG affinity. …”

Network structure of OSA. by Wenshun Sheng (21485393)

“…OSA is highly sensitive to information of different scales, and its one-time aggregation property substantially decreases the computational overhead of the model. …”

DataSheet1_Erlotinib regulates short-term memory, tau/Aβ pathology, and astrogliosis in mouse models of AD.doc by Hyun-ju Lee (7550741)

“…Moreover, erlotinib treatment decreased astrogliosis in 6-month-old PS19 mice and reduced proinflammatory responses in primary astrocytes (PACs) from PS19 mice. …”