Showing 161 - 180 results of 6,454 for search '(( significantly ((elevated decrease) OR (greater decrease)) ) OR ( significant role decrease ))', query time: 0.51s Refine Results
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    Advantages of Novel Anti-cancer Selenosemicarbazones: Preferential Reactivity of Their Fe(III), Cu(II), and Zn(II) Complexes with Key Physiological Reductants/Ligands Versus Isoste... by Mahendiran Dharmasivam (14165426)

    Published 2025
    “…Considering this: (1) [Fe(PPP4pSe)<sub>2</sub>]<sup>+</sup> demonstrated increased reduction relative to [Fe(PPP4pT)<sub>2</sub>]<sup>+</sup> with glutathione and l-cysteine, while l-ascorbate led to comparable reduction; (2) glutathione led to complete dissociation of [Zn(PPP4pSe)<sub>2</sub>], while incomplete dissociation of [Zn(PPP4pT)<sub>2</sub>] occurred; and (3) [Cu(PPP4pSe)Cl] demonstrated complete coordinate sphere substitution with glutathione, l-cysteine, and l-ascorbate, whereas [Cu(PPP4pT)Cl] demonstrated partial substitution. The role of glutathione in all three latter reactions is significant, given the greater reactivity of the selenosemicarbazone, and glutathione’s key role in selenosemicarbazone and thiosemicarbazone anticancer activity.…”
  8. 168

    Advantages of Novel Anti-cancer Selenosemicarbazones: Preferential Reactivity of Their Fe(III), Cu(II), and Zn(II) Complexes with Key Physiological Reductants/Ligands Versus Isoste... by Mahendiran Dharmasivam (14165426)

    Published 2025
    “…Considering this: (1) [Fe(PPP4pSe)<sub>2</sub>]<sup>+</sup> demonstrated increased reduction relative to [Fe(PPP4pT)<sub>2</sub>]<sup>+</sup> with glutathione and l-cysteine, while l-ascorbate led to comparable reduction; (2) glutathione led to complete dissociation of [Zn(PPP4pSe)<sub>2</sub>], while incomplete dissociation of [Zn(PPP4pT)<sub>2</sub>] occurred; and (3) [Cu(PPP4pSe)Cl] demonstrated complete coordinate sphere substitution with glutathione, l-cysteine, and l-ascorbate, whereas [Cu(PPP4pT)Cl] demonstrated partial substitution. The role of glutathione in all three latter reactions is significant, given the greater reactivity of the selenosemicarbazone, and glutathione’s key role in selenosemicarbazone and thiosemicarbazone anticancer activity.…”
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