Data Sheet 2_Investigating the impact of microcalcification size and volume on collagenous matrix and tissue mechanics using a tissue-engineered atherosclerotic cap model.docx by Imke L. Jansen (22089944)

“…To mimic human microcalcification size and volume, hydroxyapatite microparticles, in two size ranges (diameter up to 5 μm or up to 50 μm) and two volumes (1 v/v% and 5 v/v%) were incorporated homogenously throughout the tissue-engineered model. 5 v/v% of particles caused a significant lowering of the mechanical properties as was shown by a decrease in stiffness and ultimate tensile stress under uniaxial tensile loading. …”

Table 1_Associations between physical activity and cardiorespiratory fitness and adverse outcomes in patients with atrial fibrillation: a prospective cohort study.pdf by Yanwen Chen (460790)

“…All levels of PA were significantly associated with a decreased risk of cardiovascular death with HRs ranging from 0.577 to 0.938 (P < 0.01). …”

Table 2_Associations between physical activity and cardiorespiratory fitness and adverse outcomes in patients with atrial fibrillation: a prospective cohort study.pdf by Yanwen Chen (460790)

“…All levels of PA were significantly associated with a decreased risk of cardiovascular death with HRs ranging from 0.577 to 0.938 (P < 0.01). …”

Rescue of <i>pbp1</i>-KD phenotypes using CRISPRi trans-complementation. by Gregory A. Harrison (16639446)

“…Yellow arrows point to a subset of PBP1-depleted cells that have decreased RADA signal, likely due to decreased peptidoglycan metabolism. …”

Data Sheet 1_Impact of finerenone on chronic kidney disease progression in Chinese patients with type 2 diabetes: a FIGARO-DKD subgroup analysis.docx by Ping Li (31981)

“…Finerenone resulted in a numerical decrease in the risk of the cardiovascular composite outcome (hazard ratio 0.91; 95% confidence interval 0.50–1.67) and a significantly reduced risk of the key secondary kidney outcome (hazard ratio 0.48; 95% confidence interval 0.29–0.79; p = 0.0029). …”

The protective effects of neferine against paracetamol-induced liver injury are associated with the activation of SIRT1/Nrf2/HO-1 signaling pathway and inhibition of NF-kappa B/TNF... by Mohammed A. Altowijri (22461945)

“…<p>Drug-induced hepatotoxicity is a significant public health issue that influences the development of novel pharmaceutical therapies and the retraction of numerous promising medications from the market. …”

Supplementary file 1_Short-term fasting before living kidney donation has an immune-modulatory effect.pdf by Christiaan A. J. Oudmaijer (12006320)

“…STF changes the levels and phenotype of immune cells, reducing the abundance and activation of T cells, including regulatory T cells, increased presence of (naïve) B cells, and elevation of type 1 conventional DCs (cDC1s). In addition, a decrease in central memory T cells was observed.…”

Data Sheet 1_Short-term fasting before living kidney donation has an immune-modulatory effect.docx by Christiaan A. J. Oudmaijer (12006320)

“…STF changes the levels and phenotype of immune cells, reducing the abundance and activation of T cells, including regulatory T cells, increased presence of (naïve) B cells, and elevation of type 1 conventional DCs (cDC1s). In addition, a decrease in central memory T cells was observed.…”

Table 1_Gut microbiota alterations and systemic inflammation in community-acquired pneumonia: a prospective gut-lung axis study.docx by Xue-Qin Yang (3494345)

“…The abundance of short-chain fatty acid-producing genera in CAP patients decreased significantly, such as Blautia and Agathobacter. …”

Table 1_Disc degeneration influences the strain magnitude and stress distribution within the adjacent trabecular bone.docx by Kay A. Raftery (17080234)

“…Von Mises stress distribution was significantly skewed towards the anterior region in the degenerated group only (28.3% ± 10.4%, p < 0.05). …”

Data Sheet 1_Global burden of cancer in adolescents and young adults aged 10–24 years: a trend analysis.pdf by Junjun Yang (307892)

“…The age-standardized death rate(ASDR) and age-standardized DALY rate of total cancer have decreased significantly globally in adolescents and young adults aged 10–24 years. …”

Table 2_The burden of chronic kidney disease attributable to high sodium intake: a longitudinal study in 1990–2019 in China.docx by Yongyao Shen (20561210)

“…Despite a slight decreasing trend exists, the absolute number increased as much as twofold, particularly among males and seniors. …”

Table 1_The burden of chronic kidney disease attributable to high sodium intake: a longitudinal study in 1990–2019 in China.docx by Yongyao Shen (20561210)

“…Despite a slight decreasing trend exists, the absolute number increased as much as twofold, particularly among males and seniors. …”

Data Sheet 1_Thymoquinone/β-N-acetylglucosaminidase, a novel plant-derived combination, inhibited quorum sensing signaling pathways and disrupted biofilm in Staphylococcus aureus.p... by Adel Attia M. Ahmad (16729177)

“…Notably, NAGase, whether used alone or in conjunction with TQ, led to a decrease in the expression of the atl, icaA, and agr genes.…”

An improved <i>in vitro</i> 3T3-L1 adipocyte model of inflammation and insulin resistance by Ifeoluwa A. Odeniyi (19862796)

“…Importantly, insulin resistance and inflammation were still induced in the 12 h treated adipocytes: the expression of the insulin sensitive and inflammatory genes was decreased and increased, respectively. In 72 h treated adipocytes, no significant differences were found in the viability, glucose uptake or insulin-sensitive and inflammatory gene expression. …”

Table 1_Development of the breastfed infant oral microbiome over the first two years of life in the BLOSOM Cohort.docx by Roaa A. Arishi (21089924)

“…Introduction of solid foods was a significant milestone in oral microbiome development, triggering an increase in bacterial diversity (richness P = 0.0004; Shannon diversity P = 0.0007), a shift in the abundance of seven species, and a change in beta diversity (P = 0.001).…”

Table 1_Glyoxalase 1 gene expression in various types of cancer cells immunopathology: a pan-cancer analysis study.docx by Ali M. Alaseem (21709589)

“…In summary, our study highlights GLO-1 as a significant biomarker across multiple cancers that plays a key role in cancer progression, immune modulation, and therapeutic response.…”

Table 1_Deep brain stimulation for obsessive compulsive disorder leads to symptom changes of comorbid irritable bowel syndrome.docx by Mohamed A. Abdelnaim (16976001)

“…Introduction<p>Irritable bowel syndrome (IBS) is a common condition characterized by abdominal pain and altered bowel habits, affecting around 11% of individuals globally. …”

Data Sheet 1_Menthacarin, a proprietary combination of peppermint and caraway oil, alters cultured human fecal microbiota composition, resulting in increased SCFA production.pdf by Martin D. Lehner (3350846)

“…At the genus level, the most notable changes were significant increases in Bifidobacterium (+105.1 ± 78.4%) and several SCFA-producing genera accompanied by a significant decrease in genera containing members involved in pro-inflammatory processes. …”

Data Sheet 1_Non-linear association between the dietary index for gut microbiota and the atherogenic index of plasma: insights from a cross-sectional study.docx by Tian-Ding Liu (21659201)

“…Below this threshold, the association was nonsignificant; however, above it, each unit increase in DI-GM corresponded to a 0.011 decrease in AIP (P < 0.001). Subgroup analyses indicated that the relationship between DI-GM and AIP was significantly moderated by age, race/ethnicity, hypertension, and diabetes (P for interaction < 0.05).…”