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18141
Table 1_Loss of calcium/calmodulin-dependent protein kinase kinase 2, transferrin, and transferrin receptor proteins in the temporal cortex of Alzheimer’s patients postmortem is as...
Published 2024“…Iron content in cortical tissues was measured using a colorimetric assay.</p>Results<p>CAMKK2, TF, and TFRC levels were significantly decreased in AD patients’ temporal cortices compared to CN individuals, independent of age or postmortem interval-related changes. …”
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18142
Table1_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d...
Published 2024“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”
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18143
Table6_Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer’s d...
Published 2024“…The results demonstrated that the combined administration of these 4 components (CPGB) had superior mitigating effects on AD cell model, as evidenced by the reduced pro-inflammatory cytokine production and decreased deposition of Aβ protein. Further in vivo and in vitro experiments confirmed that varying doses of CPGB formula effectively ameliorated STZ-induced cognitive deficits, as shown by NOR, MWM, and EMP tests, as well as pathological changes in hippocampal tissues and a 3-dimensional brain neurovascular unit (3D-NVU) model, including decreased deposition of Aβ protein and formation of plaques. …”
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18144
Image 3_Loss of calcium/calmodulin-dependent protein kinase kinase 2, transferrin, and transferrin receptor proteins in the temporal cortex of Alzheimer’s patients postmortem is as...
Published 2024“…Iron content in cortical tissues was measured using a colorimetric assay.</p>Results<p>CAMKK2, TF, and TFRC levels were significantly decreased in AD patients’ temporal cortices compared to CN individuals, independent of age or postmortem interval-related changes. …”
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18145
Table 1_CD9 regulates proliferation, invasion, migration and radioresistance of esophageal squamous cell carcinoma by activating AKT/GSK3β signaling pathway.docx
Published 2025“…Background<p>Radioresistance poses a major therapeutic challenge in ESCC, significantly impacting patient prognosis. …”
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18146
Supplementary Material for: Head positioning for stroke blood flow augmentation assisting reperfusion therapies (HEAD-START) study
Published 2025“…Trendelenburg positioning was maintained for 24h if lesion volume significantly decreased (≥5mL) and stroke reperfusion was suboptimal or undetermined. …”
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18147
Cell viability and comparison of cells’ reactive oxygen species (ROS) in stress environments.
Published 2025“…Results are presented as *** P < 0.001. ROS levels were significantly decreased under stress conditions in the co-cultured cells.…”
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18148
Forty years of climatic and human management controls on winter flooding of rice fields in Albufera of Valencia wetland, Spain
Published 2025“…The Normalized Difference Water Index (NDWI) was used to determine the flooded area and to develop an equation to estimate the flood level, which facilitated the calculation of the flood water volume. A decreasing trend in winter precipitation was associated with climate change as well as a reduction in flooded area not related to precipitation, suggesting a significant influence of human management of the area. …”
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18149
The feasibility of the Todoist application to assist students with time management
Published 2025“…Thesignificant issue emerges because a high number of students dedicate long periods to social media usage, resulting in decreased academic achievement. …”
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18150
Data Sheet 1_Integrated transcriptomic analysis identifies lactylation-linked gemcitabine resistance and therapeutic targets in intrahepatic cholangiocarcinoma.docx
Published 2025“…Background<p>Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive malignancy of the bile ducts, and resistance to gemcitabine, a first-line chemotherapy, significantly complicates treatment. …”
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18151
Data Sheet 1_Study of pain perception under negative emotions and its large-scale brain network dynamics in adolescents with non-suicidal self-injury.zip
Published 2025“…Conversely, the occurrence frequency of microstate B decreased markedly. Under neutral emotion induction, the MDD group exhibited higher occurrence frequency of microstate A and transition rate from microstate D→A than the HC group. …”
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18152
Table 1_High-calcium milk improves osteoporosis in postmenopausal women by regulating intestinal flora and steroid hormone biosynthesis.docx
Published 2025“…</p>Results<p>A one-year randomized controlled trial showed that the high-calcium milk group significantly increased lumbar spine bone mineral density (L1-4 BMD), slowed bone loss in the left hip and femoral neck, elevated serum phosphorus and 25-hydroxyvitamin D levels, and modulated the bone formation marker procollagen type I N-terminal propeptide compared with the regular milk group at 6 months. 16S ribosomal ribonucleic acid sequencing showed that high-calcium milk significantly altered the β-diversity of the intestinal flora, increasing the abundance of beneficial bacteria such as Bacteroides, Oscillibacter, and Subdoligranulum, while decreasing the abundance of Firmicutes and Weissella at 12 months. …”
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18153
Optimisation of read depth, DNA quantity, and unique alternate observation threshold.
Published 2025“…Lower read depth may contribute to an overestimated VAF of very small variants, although differences did not reach significance. D-F: Blood samples from 383 community-dwelling subjects were sequenced at a target depth of 3,000-4,000 × . …”
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18154
Image 1_Hyperbaric oxygen pretreatment on endothelial cell injury via heat shock factor 1 in decompression sickness.tif
Published 2025“…Bubble-induced injury significantly decreased the viability of PMVECs and increased the levels of endothelial microparticles, inflammatory cytokines, and endothelial injury markers in culture media. …”
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18155
Image 2_Hyperbaric oxygen pretreatment on endothelial cell injury via heat shock factor 1 in decompression sickness.tif
Published 2025“…Bubble-induced injury significantly decreased the viability of PMVECs and increased the levels of endothelial microparticles, inflammatory cytokines, and endothelial injury markers in culture media. …”
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18156
Table 1_Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production.docx
Published 2025“…</p>Results<p>We identified two significantly distinct profiles of endothelial markers response, characterized by either increased or decreased serum levels of endocan and sVCAM. …”
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18157
DataSheet1_Synergistic effects of SAP and PGPR on physiological characteristics of leaves and soil enzyme activities in the rhizosphere of poplar seedlings under drought stress.pdf
Published 2024“…Compared with normal watering, the DR treatment significantly decreased the contents of dehydroascorbate (DHA; 19.08%), reduced glutathione (GSH; 14.18%), oxidized glutathione, soluble protein (26.84%), indoleacetic acid (IAA; 9.47%), gibberellin (GA) and zeatin (ZT), the IAA/abscisic acid (ABA), GA/ABA, ZT/ABA and (IAA+GA+ZT)/ABA (34.67%) ratios in leaves, and the urease and sucrase activities in the rhizosphere soil. …”
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18158
Data Sheet 1_Polydatin combined with hawthorn flavonoids alleviate high fat diet induced atherosclerosis by remodeling the gut microbiota and glycolipid metabolism.pdf
Published 2025“…</p>Results<p>Polydatin combined with hawthorn flavonoids administration significantly reduced lipid and inflammatory cytokine levels, meanwhile, the atherosclerotic lesions in a high-fat diet-induced ApoE<sup>−/−</sup> mice were significantly decreased. …”
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18159
Data Sheet 1_NLRP3 regulates epithelial barrier integrity and protects from airway hyperresponsiveness in experimental allergic asthma.pdf
Published 2025“…Analysis of epithelial cell markers revealed decreased gene expression of the tight junction proteins Cld-18 and Tjp-1, and decreased expression of the epithelial transmembrane protein E-cadherin in the lungs of naïve NLRP3<sup>-/-</sup> mice compared to WT mice. …”
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18160
Data Sheet 1_Physical and biogeochemical processes in controlling the seasonal variation of dissolved oxygen in the Bohai and Yellow Seas.pdf
Published 2025“…<p>Deoxygenation in coastal seas has significant implications to the marine ecosystems. In this study, the processes influencing the seasonal variation of dissolved oxygen (DO) in the Bohai and Yellow Seas (BS and YS) are investigated using a coupled physical-biogeochemical model. …”