Table 1_Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells.xlsx by Joshua Flynn (2544523)

“…</p>Methods<p>This study utilised a targeted single-cell multi-omics approach to characterise peripheral blood mononuclear cell (PBMC) populations and their transcriptomic profiles in an Irish cohort of people with (i) sepsis and (ii) bacteraemia without sepsis (defined as clinically significant positive blood culture without sepsis as assessed by the Clinical Microbiology service).…”

Data Sheet 2_Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells.docx by Joshua Flynn (2544523)

“…</p>Methods<p>This study utilised a targeted single-cell multi-omics approach to characterise peripheral blood mononuclear cell (PBMC) populations and their transcriptomic profiles in an Irish cohort of people with (i) sepsis and (ii) bacteraemia without sepsis (defined as clinically significant positive blood culture without sepsis as assessed by the Clinical Microbiology service).…”

Data Sheet 1_Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of CD69 expressing naïve CD4+ T cells.docx by Joshua Flynn (2544523)

“…</p>Methods<p>This study utilised a targeted single-cell multi-omics approach to characterise peripheral blood mononuclear cell (PBMC) populations and their transcriptomic profiles in an Irish cohort of people with (i) sepsis and (ii) bacteraemia without sepsis (defined as clinically significant positive blood culture without sepsis as assessed by the Clinical Microbiology service).…”

Raw Data by Kevin Gries (21956942)

“…These findings indicate that a single day of reduced physical activity can elicit modest but significant changes in the metabolic and transcriptomic exercise response. …”

Combating Chemoresistance in Breast Cancer: Exploring Tumor Microenvironment, Combination Therapies, and Drug Repurposing Strategies by Shazia Sofi (17764488)

“…Chemoresistance in cancer can arise from a variety of molecular mechanisms, including active drug expulsion (drug efflux), decreased drug uptake, enhanced DNA repair mechanisms, the ability of cancer cells to evade programmed cell death (apoptosis), the diversity in the population of cancer cells within a tumor (tumor heterogeneity), and significant alterations in the tumor microenvironment (TME), where interactions between cancer cells, cancer-associated fibroblasts, immune cells, and the extracellular matrix contribute to a supportive environment that allows tumors to survive treatment and escape therapy. …”

Data Sheet 1_Association between the American Heart Association’s New Life’s Essential 8 Metrics and Depression Symptom in U.S General Adults, Finding from NHANES 2005-2018.docx... by Zhuoer Ruan (20278014)

“…The study revealed that individuals with positive scores in both individual and total LE8 metrics were less likely to experience depressive symptoms compared to those with negative scores. Furthermore, a significant negative linear trend was observed, showing that as the overall number of favorable LE8 scores increased, the likelihood of depressive symptoms decreased.…”

Supplementary file 1_Monitoring the dual-season hydrological dynamics of the Pong reservoir in Himachal Pradesh, India.docx by Rajesh Sarda (13162317)

“…The study employed a spatial linear trend modelling approach to identify trends in relative water depth, revealing a decreasing trend and a quantifiable reduction in the reservoir’s depth for both seasons. …”

Supplemental Tables S1-S5 by Kevin Gries (21956942)

“…These findings indicate that a single day of reduced physical activity can elicit modest but significant changes in the metabolic and transcriptomic exercise response. …”

Table 2_Integrated metabolomics and gut microbiota analysis to explore the potential mechanism of levo-tetrahydropalmatine against ketamine addiction.xlsx by Yan Du (229593)

“…Introduction<p>Metabolic and gut microbiota (GM) disturbance play a significant role in the complex pathogenesis of substance dependence. …”

Image 2_Endocrine-disrupting effects of environmental BPS and PFOS on human brain organoid development.tiff by Andrea Di Credico (13137135)

“…PFOS exposure coincided with decreased transthyretin expression, suggesting a potential influence on thyroid hormone availability.…”

The framework of this study. by Yin Yu (3139023)

“…The results show that (1) the landscape pattern changed visibly from 2000 to 2020, the comprehensive land-use dynamics increased from 8.53% to 9.66%, and the land use dynamics are greatest and change most dramatically on construction sites; (2) the landscape ecological risk level of the study area as a whole showed a declining trend, and 96.82% of the ecological risk plot index decreased, and the risk distribution was dominated by lower risk, medium risk and higher risk areas; (3) landscape ecological risk was spatially positively correlated across all time periods, and the spatial aggregation was gradually weakened, with the distribution of LH and HL areas dispersed and the distribution of HH and LL areas concentrated. …”

Table 1_Integrated metabolomics and gut microbiota analysis to explore the potential mechanism of levo-tetrahydropalmatine against ketamine addiction.xlsx by Yan Du (229593)

“…Introduction<p>Metabolic and gut microbiota (GM) disturbance play a significant role in the complex pathogenesis of substance dependence. …”

Image 1_Endocrine-disrupting effects of environmental BPS and PFOS on human brain organoid development.tiff by Andrea Di Credico (13137135)

“…PFOS exposure coincided with decreased transthyretin expression, suggesting a potential influence on thyroid hormone availability.…”

Supplementary file 1_Modulatory effects of transcranial direct current stimulation on sensory gating in Fibromyalgia Syndrome.docx by Juan L. Terrasa (5506691)

“…This modulation manifested as an increased difference in the right hemisphere (contralateral to the stimulation) and a decreased difference in the left hemisphere (ipsilateral).…”

HDX profile changes of βarr2 upon co-incubation with C7pp2. by Jeong Seok Ji (22008582)

“…Differences smaller than 0.2 Da were not considered significant. The data underlying the graphs shown in the figure can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003312#pbio.3003312.s009" target="_blank">S1 Data</a>.…”

Data Sheet 1_Potential geographical distribution of Cordyceps cicadae and its two hosts in China under climate change.docx by Junyi Chen (776323)

“…C. cicadae thrived on steep slopes. and some of which also significantly affect the distribution of its two hosts. …”

Data Sheet 1_Water quality and fluorescent dissolved organic matter dynamics of Dhaleshwari River.pdf by Mohammad Mohinuzzaman (18275214)

“…The socioeconomic and ecological significance of the river is highly critical to the locality. …”

Location of the study area. by Yunxia Zhang (30848)

“…The results show that: (1) the level of non-grain of cultivated land in Lianyungang City increased gradually from 6.01% to 11.10% from 2002 to 2022, and grain cultivation was mainly shifted to greenhouse vegetables, construction and development and abandonment. (2) the level of non-grain of cultivated land showed a spatial pattern of high along the north-west-south-east and decreasing to the two sides, and the pattern showed a trend of gradual weakening, with Moran’s I decreased from 0.90 to 0.42. (3) The dominant factors of the spatial differentiation of non-grain of cultivated land in different periods are different, among which GDP, population density, NDVI, and precipitation are always the main influencing factors. …”

Influencing factor index system. by Yunxia Zhang (30848)

“…The results show that: (1) the level of non-grain of cultivated land in Lianyungang City increased gradually from 6.01% to 11.10% from 2002 to 2022, and grain cultivation was mainly shifted to greenhouse vegetables, construction and development and abandonment. (2) the level of non-grain of cultivated land showed a spatial pattern of high along the north-west-south-east and decreasing to the two sides, and the pattern showed a trend of gradual weakening, with Moran’s I decreased from 0.90 to 0.42. (3) The dominant factors of the spatial differentiation of non-grain of cultivated land in different periods are different, among which GDP, population density, NDVI, and precipitation are always the main influencing factors. …”

Supplementary file 1_Cistanche tubulosa glycosides ameliorate cognitive decline in APP/PS1 mice via modulation of gut microbiota and fatty acid metabolism: insights from multi-omic... by Rui Hou (161624)

“…</p>Results<p>GCT treatment significantly improved spatial memory and reduced the protein levels of Aβ and proinflammatory factors in APP/PS1 mice. …”