Data Sheet 1_Breaking the cancer code: a novel DNA minicircle to disable STAT3 in ovarian cancer cells SKOV3.docx by Adina-Gabriela Vasilescu (22236073)

“…Mechanistically, anti-STAT3 mcDNA induces apoptosis and necrosis in treated cells, also revealing a certain dose-dependency, while also decreasing cell proliferation. Finally, our inhibitor significantly downregulates STAT3-dependent anti-apoptotic genes MCL1 and PIM1.…”

Table 5_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.docx by Tien Le (634791)

“…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…”

Green Fabrication of Biobased and Degradable Poly(lactic acid)/Poly(butylene succinate) Open-Cell Foams for Highly Efficient Oil–Water Separation with Ultrafast Degradation by Jie Yuan (208425)

“…It is notable that different cell structures of varying sizes show significant differences in the adsorption capacity and rate. …”

Study of monopolar plate springback applying zoned multistage forming process by Jiabo Zhang (10076842)

“…The length and width of an MPP both exceed 150 mm, but the thickness of its raw material plate is less than 0.1 mm, posing a significant challenge to the uniformity of its thickness after forming. …”

Table 1_Survival assessment in extremely preterm neonates in a middle-income setting.docx by Maria J. Rodriguez-Sibaja (17456689)

“…Notably, survival after extremely preterm birth was associated with significant morbidity.</p>…”

Table 1_Dihydromyricetin attenuates age-related macular degeneration: pharmacological effects and exploration of putative targets.docx by Hongyu Zhou (352858)

“…Western blot analysis further confirmed DHM-mediated suppression of apoptosis through regulation of p53, Bax, cleaved caspase-3, and Bcl-2 expression. High-dose DHM significantly attenuated retinal thinning (10.7% reduction), decreased pigment loss, and ameliorated structural disorganization in the outer nuclear layer (ONL). …”

Image2_Predicting candidate miRNAs for targeting begomovirus to induce sequence-specific gene silencing in chilli plants.jpeg by Vineeta Pandey (10043698)

“…Chilli cultivars infected with begomovirus have suffered significant decreases in biomass output, negatively impacting their economic characteristics. …”

Data Sheet 1_Effects and safety of Salvia miltiorrhiza on the improvement of renal function, inflammatory factors, and vascular endothelium in patients with diabetic kidney disease... by Shuyu Zheng (5570231)

“…Notably, the safety profile remained sound, with no significant differences in adverse event rates between the two groups (P > 0.05).…”

Table 5_Rapid reshaping of the soil microbiome and metabolome during short-term flooding and draining in rice.xlsx by Yanyao Lu (22163632)

“…The results revealed that S-PPO, S-POD, and S-CAT decreased with prolonged drainage time, whereas the soil redox potential (Eh-mV) and POD increased. …”

Image 4_A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression.tiff by Tien Le (634791)

“…Crim1 encodes a type I transmembrane protein that is expressed at the cell membrane of lens epithelial and fiber cells at the stage of lens pit formation. Decreased Crim1 expression in the mouse reduced the number of lens epithelial cells and caused defective adhesion between lens epithelial cells and between the epithelial and fiber cells.…”

Table_1_Antioxidants and the risk of sleep disorders: results from NHANES and two-sample Mendelian randomization study.docx by Junjie Jiang (7255706)

“…</p>Results<p>Analysis of data from the 2011–2018 NHANES survey revealed a significant negative association between CDAI and sleep disorders (OR = 0.854, 95% CI 0.821–0.888, P < 0.001). …”

Image_2_Effect of probiotic supplementation combined with bismuth-containing quadruple therapy on gut microbiota during Helicobacter pylori eradication: a randomized, double-blind,... by Zhongxue Han (19855215)

“…After treatment, the GSRS score decreased significantly in the probiotic group (p = 0.039). …”

Supplementary Material for: The value of circulating tumor DNA in the prognostic diagnosis of bladder cancer: a systematic review and meta-analysis by figshare admin karger (2628495)

“…Deeks funnel plot analysis showed no significant publication bias (P=0.24). However, inter-study heterogeneity was high (all I² values >80%), which may have been influenced by factors such as assay technique, patient characteristics, and follow-up time. …”

DataSheet1_Neuroprotective effect of Bouvardia ternifolia (Cav.) Schltdl via inhibition of TLR4/NF-κB, caspase-3/Bax/Bcl-2 pathways in ischemia/reperfusion injury in rats.PDF by Yury Maritza Zapata-Lopera (19725616)

“…This lowers oxidative stress and decreases the expression of proteins and genes linked to cell death, such as Bax, Bcl-2, and caspase-3. …”

Table 1_Untargeted metabolic analysis in serum samples reveals metabolic signature in children with congenital heart failure on enalapril therapy.csv by N. J. L. Smeets (21188726)

“…Patients were defined as responder when aldosterone levels decreased after a single administration of enalapril. …”

Data Sheet 5_Rapid reshaping of the soil microbiome and metabolome during short-term flooding and draining in rice.docx by Yanyao Lu (22163632)

“…The results revealed that S-PPO, S-POD, and S-CAT decreased with prolonged drainage time, whereas the soil redox potential (Eh-mV) and POD increased. …”

Image 3_The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis... by Yuchan Zhong (22518395)

“…The results showed that antioxidant supplementation significantly alleviated pelvic pain (continuous outcomes: SMD = −2.68; p < 0.00001; binary outcomes: RR = 9.31; p < 0.0001), dysmenorrhea (SMD = −1.77; p = 0.01; RR = 2.39; p = 0.03), and dyspareunia (SMD = −2.33; p = 0.01; RR = 5.40; p = 0.003), and significantly decreased peripheral blood malondialdehyde (MDA) levels (SMD = −7.58; p = 0.001). …”

Table 2_Apoptosis and autophagy promote Babesia microti infection in tick midguts: insights from transcriptomic and functional RNAi studies.docx by Songqin Chen (9625886)

“…Functional assays demonstrated that RNA interference (RNAi)-mediated knockdown of caspase-7, caspase-9, and ATG5 significantly reduced the burden of B. microti. Conversely, pharmacological induction of autophagy using rapamycin increased B. microti load, whereas inhibition with 3-methyladenine (3-MA) decreased B. microti load.…”

Table 2_Global, regional, and national burden of musculoskeletal disorders, 1990–2021: an analysis of the global burden of disease study 2021 and forecast to 2035.doc by Meizhi Liu (21898892)

“…Frontier analysis revealed significant gaps between current burdens and achievable benchmarks, particularly in high-SDI regions, while some low-SDI regions demonstrated effective management despite limited resources. …”

Image2_Integrating anoikis and ErbB signaling insights with machine learning and single-cell analysis for predicting prognosis and immune-targeted therapy outcomes in hepatocellula... by Huipeng Fang (12587509)

“…Background<p>Hepatocellular carcinoma (HCC) poses a significant global health challenge due to its poor prognosis and limited therapeutic modalities. …”