Image2_Causal effect of immune cells, metabolites, cathepsins, and vitamin therapy in diabetic retinopathy: a Mendelian randomization and cross-sectional study.png حسب Huijun Zhou (60485)

"…Cross-sectional data indicated that vitamins B1, B2, B6, B12, and E progressively decreased with DR severity.</p>Conclusion<p>This study is the first to identify CAT H as a key risk factor for DR, while vitamins B6 and E showed significant protective effects, particularly against PDR. …"

Supplementary file 1_Translocator protein deficiency blocks the ferroptosis of malignant peripheral nerve sheath tumors through glutathione peroxidase 4.pdf حسب Xiaoli Zhang (135098)

"…TSPO-knockdown MPNST cells exhibited significant resistance to ferroptotic cell death. Additionally, biochemical characterization indicated that TSPO deficiency decreased intracellular Fe²⁺ and ROS. …"

Image 2_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif حسب Ying Dong (41989)

"…Background<p>Psoriasis is a chronic immune-mediated skin disorder characterized by excessive keratinocyte proliferation and localized inflammation. …"

DataSheet1_Scutellarein ameliorates dextran sulfate sodium-induced ulcerative colitis by inhibiting colonic epithelial cell proinflammation and barrier disruption.DOC حسب Qinglian Tang (9162473)

"…</p>Results<p>Gavage of Scu significantly decreased the DAI score, improved colon shortening, ameliorated the pathological score in DSS-treated mice with better efficacy than the positive drug, 5-aminosalicylic acid. …"

Data Sheet 1_miR-223 alleviates DSS-induced colitis by prompting macrophage M2 polarization through PPAR-γ/FOXO1 signaling.pdf حسب Juanjuan Zhang (432819)

"…</p>Results<p>Histopathological analysis showed that miR-223 agomir significantly attenuated DSS-induced colon damage. Proinflammatory cytokines (TNF-α, IL-1β, IL-6) increased in DSS mice, while anti-inflammatory IL-10 decreased—trends reversed by miR-223 supplementation at mRNA/protein levels. …"

Table 4_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.xlsx حسب Ying Dong (41989)

"…Background<p>Psoriasis is a chronic immune-mediated skin disorder characterized by excessive keratinocyte proliferation and localized inflammation. …"

Table1_SMAD4 enhances the cytotoxic efficacy of human NK cells against colorectal cancer cells via the m6A reader YTHDF2.docx حسب Xinxin Li (281237)

"…</p>Results<p>Our findings revealed that the expression of SMAD4 is decreased in NK cells within the TME of human CRC. …"

Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of <i>Pseudomonas aeruginosa</i> in an organotypic 3D lung epithelial cell model حسب Merel Wauters (21333023)

"…Compared to the <i>lasB</i> mutant, the wild-type strain significantly decreased inflammation by degrading MCP-1, IL-1β, GM-CSF, and IL-8. …"

Image1_Causal effect of immune cells, metabolites, cathepsins, and vitamin therapy in diabetic retinopathy: a Mendelian randomization and cross-sectional study.png حسب Huijun Zhou (60485)

"…Cross-sectional data indicated that vitamins B1, B2, B6, B12, and E progressively decreased with DR severity.</p>Conclusion<p>This study is the first to identify CAT H as a key risk factor for DR, while vitamins B6 and E showed significant protective effects, particularly against PDR. …"

Table 8_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.xlsx حسب Ying Dong (41989)

"…Background<p>Psoriasis is a chronic immune-mediated skin disorder characterized by excessive keratinocyte proliferation and localized inflammation. …"

Image 4_Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis.tif حسب Ying Dong (41989)

"…Background<p>Psoriasis is a chronic immune-mediated skin disorder characterized by excessive keratinocyte proliferation and localized inflammation. …"

Data Sheet 1_Association of estimated glucose disposal rate with atrial fibrillation, heart failure and cardiovascular mortality in patients with diabetes: a prospective cohort stu... حسب Zhen Tan (384977)

"…Subgroup analysis was performed using cardiovascular high-risk factors, and mediation analysis explored the relationships of eGDR with the outcomes.…"

Table 1_Pingwei Powder alleviates high-fat diet-induced colonic inflammation by modulating microbial metabolites SCFAs.xlsx حسب Tangjuan Liu (2634649)

"…Experimental validation showed that PWP significantly downregulated the levels of PI3K, pAKT/AKT, and pmTOR/mTOR in colonic tissue, thereby enhancing autophagy in colonic epithelial cells, as evidenced by decreased levels of P62 and increased LC3B-II/LC3B-I ratios. …"

Table 1_A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.docx حسب Paolo Romania (399007)

"…</p>Results<p>We identified ten candidate genes whose downregulation in K562 cells decreased NK cell-mediated cytotoxicity to levels comparable to silencing the MICA gene. …"

Image 3_A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.jpg حسب Paolo Romania (399007)

"…</p>Results<p>We identified ten candidate genes whose downregulation in K562 cells decreased NK cell-mediated cytotoxicity to levels comparable to silencing the MICA gene. …"

Image 1_A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.jpg حسب Paolo Romania (399007)

"…</p>Results<p>We identified ten candidate genes whose downregulation in K562 cells decreased NK cell-mediated cytotoxicity to levels comparable to silencing the MICA gene. …"

Image 4_A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.jpg حسب Paolo Romania (399007)

"…</p>Results<p>We identified ten candidate genes whose downregulation in K562 cells decreased NK cell-mediated cytotoxicity to levels comparable to silencing the MICA gene. …"

Table 2_A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.docx حسب Paolo Romania (399007)

"…</p>Results<p>We identified ten candidate genes whose downregulation in K562 cells decreased NK cell-mediated cytotoxicity to levels comparable to silencing the MICA gene. …"

Data Sheet 6_A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.pdf حسب Paolo Romania (399007)

"…</p>Results<p>We identified ten candidate genes whose downregulation in K562 cells decreased NK cell-mediated cytotoxicity to levels comparable to silencing the MICA gene. …"

Data Sheet 4_A genome-wide shRNA screen uncovers a novel potential ligand for NK cell activating receptors.pdf حسب Paolo Romania (399007)

"…</p>Results<p>We identified ten candidate genes whose downregulation in K562 cells decreased NK cell-mediated cytotoxicity to levels comparable to silencing the MICA gene. …"