Image2_Inhibition of CISD2 enhances sensitivity to doxorubicin in diffuse large B-cell lymphoma by regulating ferroptosis and ferritinophagy.JPEG by Chaofeng Zhang (845343)

“…Background<p>CDGSH iron-sulfur domain 2 (CISD2), an iron-sulfur protein with a [2Fe-2S] cluster, plays a pivotal role in the progression of various cancers, including Diffuse Large B-cell Lymphoma (DLBCL). …”

Data Sheet 2_Comprehensive analysis of SQOR involvement in ferroptosis resistance of pancreatic ductal adenocarcinoma in hypoxic environments.docx by Quan Lin (5958)

“…SQOR knockdown resulted in decreased cell viability, decreased migration ability and increased MDA level under hypoxic Ersatin induced conditions. …”

<b>PathoBiocheModelling to manage Unknowns in Neurodevelopmental Cofactor Disorders</b> by Yuliya Buinitskaya (8680986)

“…Patient C had notable decreased activity of FAD-dependent Isovaleryl-CoA dehydrogenase (IVD). …”

Table2_Drought stress reduces arbuscular mycorrhizal colonization of Poncirus trifoliata (L.) roots and plant growth promotion via lipid metabolism.xlsx by Wei Zhang (405)

“…Results indicated that AM fungal inoculation significantly promoted the drought tolerance of P. trifoliata (L.), with the effect size decreasing along with drought severity. …”

Table 2_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…The primary outcomes included relapse rates, Expanded Disability Status Scale (EDSS) scores, and survival outcomes.</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Table 4_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…The primary outcomes included relapse rates, Expanded Disability Status Scale (EDSS) scores, and survival outcomes.</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Table 3_Clinical features and prognosis of NMOSD patients with positive autoimmune antibodies.docx by Yutao Liu (87989)

“…The primary outcomes included relapse rates, Expanded Disability Status Scale (EDSS) scores, and survival outcomes.</p>Results<p>(1) Anti-CTD Abs (+): higher proportion of female patients, increased relapse frequency; decreased red blood cell (RBC) count and aspartate aminotransferase (AST) levels. (2) ATAbs (+): greater incidence of acute brainstem syndrome (ABS); reduced peripheral leukocyte, neutrophil, and lymphocyte counts; elevated serum urea levels. (3) Double (+): marked female predominance, higher incidence of ABS, decreased RBC count, hemoglobin (Hb) levels, and cerebrospinal fluid (CSF) chloride concentration; elevated serum urea. (4) AQP4-IgG association: AQP4-IgG-positive patients were more frequently female, with higher prevalence of anti-CTD Abs positivity but lower prevalence of ATAbs positivity. (5) Prognostic analysis: both double-positive and single-antibody-positive groups showed higher disability (EDSS ≥4.0/≥6.0) compared with antibody-negative patients, although no significant differences were observed between the two single-antibody subgroups. (6) Multivariate analysis identified combined antibody positivity (OR = 16.292), baseline EDSS score (OR = 3.179), and age at onset (OR = 1.052) as independent predictors of poor clinical outcomes.…”

Areal densities of single targets in the feeding areas of northern and southern resident killer whales. by Burak Saygili (19832062)

“…Prey densities differed significantly between feeding areas, and generally decreased as the fish migrated from west to east towards the Fraser River. …”

Supplementary Material for: Atypical COVID-19-related Acute Macular Neuroretinopathy with Progression resulting in Severe Vision Loss by Weinberger E.M (20394746)

“…Introduction: We review the clinical course of a patient with decreased vision in the setting of COVID-19 infection consistent with an atypical presentation of acute macular neuroretinopathy (AMN). …”

Processed dataset for analysis. by Angela M. Klock (2631601)

“…<div><p>On the global scale, agricultural crop yields have decreased or plateaued over the last several decades. …”

Relating the biophysical forces that govern bacterial adhesion to experimental data. by Mikkel Anbo (15287803)

“…The adhesion of PA14ΔO+O4 and PA14ΔO+O12 was assayed at pH 5, 7, and 9 in the absence (left) and presence (right) of the metal chelator 1mM EDTA. Linear models of adhesion as a function of pH were made for both strains and shown as a line, for PA14ΔO+O12, or a dashed line, for PA14ΔO+O4. …”

Consort flow diagram of the participants. by Preeyaphorn Songsorn (21799601)

“…During flow incentive spirometry, stroke volume and heart rate significantly increased, while cardiac output significantly decreased compared to volume incentive spirometry and costal breathing exercises with sustained maximal inspiration throughout the 10 breathing cycles.…”

The inhibitory and anti-inflammatory effects of TMP269 on peste des petits ruminants virus replication by Miaomiao Li (483829)

“…TMP269, a selective class IIa HDAC inhibitor, plays an important role in cancer therapy and also modulates viral replication. …”

Supplementary Material for: From childhood to adolescence: Long-term trends in severe obesity in German youth (2002–2023) by figshare admin karger (2628495)

“…Results Pre-pandemic, SO remained stable or declined in children under 12 until 2010: OR5: 0.8-1, p<0.001) but rose significantly afterward (OR5: 1.1-1.2, p<0.001). …”

In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma by Joaquín Yanes-Díaz (20539584)

“…The phosphatidylinositol-3-kinase (PI3K) signaling pathway is frequently activated in HNSCC, making it an attractive target for therapies. PHT-427 is a dual inhibitor of PI3K and the mammalian target of AKT/PDK1. …”

Negative Activation Volume in Hydrated BaZr_0.8Y_0.2O_3−δ Proton Conductor at Room Temperature (Supporting Information) by Fumitada IGUCHI (20594488)

“…The bulk resistance of the material decreases as the pressure increases, with a decrement ratio from −0.6 to −2.3 % per 60 MPa variation in pressure. …”

Supplementary Material for: Exploratory Analysis of Sleep Deprivation Effects on Gene Expression and Regional Brain Metabolism by figshare admin karger (2628495)

“…For brain metabolism, sleep deprivation resulted in significant decreases in the left insula, left medial prefrontal cortex (BA32), left somatosensory cortex (BA1/2), and left motor premotor cortex (BA6) and increases in the right inferior longitudinal fasciculus, right primary visual cortex (BA17), right amygdala, left cerebellum, and bilateral pons. …”

Image_3_Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse.JPEG by Katrina S. Hofstetter (17545425)

“…EdU incorporation is significantly downregulated. In addition, mitotic retinal progenitor cells mislocalize deeper, basal regions, likely contributing to decreased proliferation. …”

Image_2_Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse.jpg by Katrina S. Hofstetter (17545425)

“…EdU incorporation is significantly downregulated. In addition, mitotic retinal progenitor cells mislocalize deeper, basal regions, likely contributing to decreased proliferation. …”

Image_2_Loss of Cdc42 causes abnormal optic cup morphogenesis and microphthalmia in mouse.jpg by Katrina S. Hofstetter (17545425)

“…EdU incorporation is significantly downregulated. In addition, mitotic retinal progenitor cells mislocalize deeper, basal regions, likely contributing to decreased proliferation. …”