Data Sheet 1_Determination of nine prostaglandins in the arachidonic acid metabolic pathway with UHPLC-QQQ-MS/MS and application to in vitro and in vivo inflammation models.docx by Yufeng Huang (782683)

“…At the same time, the levels of these PGs decreased significantly (p < 0.01 vs. LPS-induced group) after the positive drug (dexamethasone) intervention. …”

Supplementary Material for: Camrelizumab combined with Lenvatinib and RALOX-HAIC for unresectable hepatocellular carcinoma (Cal Era): a prospective, single-arm, phase II trial by figshare admin karger (2628495)

“…Grade 3-4 treatment-related adverse events occurred in 79.5% of the subjects, with the most common being decreased neutrophil count (41%), decreased platelet count (30.8%), and increased aspartate aminotransferase (23.1%). …”

Image 3_Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.tiff by José De Jesus Bravo-Silva (21898316)

“…In neonatal CD1 mice, melatonin markedly decreased viral loads in the brain and suppressed inflammatory gene expression, microglial activation, and M1/M2 polarization imbalance.…”

Image 2_Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.tiff by José De Jesus Bravo-Silva (21898316)

“…In neonatal CD1 mice, melatonin markedly decreased viral loads in the brain and suppressed inflammatory gene expression, microglial activation, and M1/M2 polarization imbalance.…”

Data Sheet 1_Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona.docx by Miquel Porta (199379)

“…</p>Results<p>Higher concentrations in 2016–17 of IL-8 and TNF-α significantly decreased the risk of SARS-CoV-2 seropositivity in 2020–21, whereas higher concentrations of MIP-1α were a risk factor for seropositivity. …”

Supplementary Material for: Emergency Renal Replacement Therapy with Manual Dialysis in a Patients with Acute Kidney Injury: First in Human Case Report by figshare admin karger (2628495)

“…Case presentation: A 37-year-old previously healthy male presented with a gunshot wound to the left leg, resulting in significant vascular injury and hemorrhagic shock requiring surgical intervention. …”

Data Sheet 3_Yerba Maté and its impact on glycemic control and metabolic health: a systematic review and meta-analysis.doc by Daiping Li (5007932)

“…The results with pre-diabetes patients suggest significant decreases in postprandial glucose (MD -12.76, 95% CI -16.78, -8.74; N = 2), HbA1c (MD -0.37, 95% CI -0.56, -0.18; N = 2), and the homeostatic model assessment index (HOMA index) (MD -0.24, 95% CI -0.37, -0.11; N = 2), though further research is needed to confirm these findings. …”

Data Sheet 2_Yerba Maté and its impact on glycemic control and metabolic health: a systematic review and meta-analysis.docx by Daiping Li (5007932)

“…The results with pre-diabetes patients suggest significant decreases in postprandial glucose (MD -12.76, 95% CI -16.78, -8.74; N = 2), HbA1c (MD -0.37, 95% CI -0.56, -0.18; N = 2), and the homeostatic model assessment index (HOMA index) (MD -0.24, 95% CI -0.37, -0.11; N = 2), though further research is needed to confirm these findings. …”

Table 1_Intrauterine infusion of autologous platelet-rich plasma modulates endometrial immune status and improves pregnancy outcomes in patients with persistent chronic endometriti... by Xian Chen (107385)

“…After PRP treatment, the proportions of endometrial CD8⁺ T cells, CD56⁺ NK cells, Foxp3⁺ Treg cells, and T-bet⁺ Th1 cells were significantly decreased in patients with persistent CE. …”

Table 1_Modulation of the gut-bone axis: Lacticaseibacillus paracasei LC86 improves bone health via anti-inflammatory metabolic pathways in zebrafish models of osteoporosis and car... by Yao Dong (3308124)

“…</p>Results<p>LC86 treatment significantly improved bone and cartilage health, as evidenced by increased fluorescence intensity in the skull, hard bone, and cartilage (p < 0.01, p < 0.05). qPCR results showed upregulation of key bone-related genes (sp7, runx2a, bmp2a, bmp4, and col2a1a), indicating enhanced bone and cartilage structure. …”

<b>Identification and Validation of LOXL2 as a Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma through Multi-Omics and Functional Analysis</b> by Ge Qiao (21802511)

“…A Cox proportional hazards model was employed to evaluate the prognostic significance and survival impact of these genes. …”

DataSheet2_Asparagus officinalis L. extract exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells and a transgenic mouse model of endometrial cancer.pdf by Ziwei Fang (10115899)

“…Asparagus officinalis extract treatment for 4 weeks resulted in a significant reduction in tumor growth in Lkb1^fl/flp53^fl/fl mice under both obese and lean conditions, with a decrease in Ki-67 and vascular endothelial growth factor expression and an increase in Bip expression in endometrial tumors.…”

Supplementary file 1_To assess the impact of individualized strategy and continuous glucose monitoring on glycemic control and mental health in pregnant women with diabetes.docx by Mengxue Liu (5953361)

“…</p>Results<p>FBG and 2hPBG significantly decreased post-intervention in both groups (P<0.001). …”

Supplementary file 2_Associations between the METS-IR index and cognitive function in community-dwelling Chinese middle-aged and older adult individuals: a cross-sectional study.do... by Nian Jiang (1338381)

“…On the left side of the endpoint, a one-unit increase in the METS-IR index was associated with a 3.1% increase in the risk of cognitive impairment. …”

Data Sheet 1_Valve-in-valve transcatheter aortic valve replacement (TAVR) leads to lower device success compared to TAVR in native stenosis.pdf by Michael Paukovitsch (16428786)

“…While ViV-TAVR decreased peak and mean gradients significantly, in 31% of patients elevated mean gradients (≥20 mmHg) were observed at discharge. …”

<b>Keystone taxa and microbial network complexity, rather than diversity, sustain soil multifunctionality along an elevational gradient in a subtropical karst mountain</b> by Weixue Luo (6070040)

“…Notably, the positive effects of network complexity and keystone taxa abundance on soil EMF decreased with increasing threshold levels of EMF, yet keystone taxa abundance retained a significant positive effect even at the highest threshold (75%). …”

Data Sheet 1_Pachymic acid alleviates metabolic dysfunction-associated steatotic liver disease by inhibiting ferroptosis through PPARα.doc by Guilin Ren (18720749)

“…Introduction<p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by excessive lipid deposition in hepatocytes without a history of significant alcohol consumption. Pachymic acid (Pac), a bioactive triterpenoid from Poria cocos, has shown promise in treating MASLD due to its antioxidant and anti-inflammatory capabilities. …”

Table 1_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.xlsx by M. Elakkya (21760439)

“…Under salt and osmotic stress, A. chroococcum W5 metabolomic profiling revealed adaptive responses, including elevated levels of osmoprotectants (proline, glycerol) and oxidative stress markers such as 2-hydroxyglutarate, while putrescine and glycine decreased.…”

Image 1_Comparative genomics and metabolomics reveal phytohormone production, nutrient acquisition, and osmotic stress tolerance in Azotobacter chroococcum W5.jpeg by M. Elakkya (21760439)

“…Under salt and osmotic stress, A. chroococcum W5 metabolomic profiling revealed adaptive responses, including elevated levels of osmoprotectants (proline, glycerol) and oxidative stress markers such as 2-hydroxyglutarate, while putrescine and glycine decreased.…”

Data Sheet 1_The impact of climate risks on green technology innovation: an empirical study based on panel data of 269 cities in China.zip by Yangyulong Wu (19867245)

“…First, the two components of climate risks—physical risks and transition risks—significantly hinder green technology innovation. Second, physical risks suppress green technology innovation by reducing market potential, while transition risks do so by decreasing foreign direct investment. …”