Image 5_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg by Xiao Li (107004)

“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”

Table 1_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.docx by Xiao Li (107004)

“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”

Image 3_Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway.jpeg by Xiao Li (107004)

“…MiR-936 overexpression and GV102-Pim-3-shRNA significantly attenuated the activity of the ANKRD18A/Src/NRF2 pathway to decrease the expression of Ankyrin repeat domain-containing protein 18A (ANKRD18A), Src, and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), especially decreasing NRF2 nuclear retention and transcriptional activity. …”

Table 1_Association between bone mineral density and stroke: a meta-analysis.docx by Peng Zhao (128233)

“…</p>Conclusion<p>Reduction in BMD is associated with a significantly increased risk of stroke. Female individuals have a higher risk than male persons.…”

DataSheet1_Cross-National Trends in Early Sexual Initiation Among 15-Year-Old Adolescents, 2002–2022.xlsx by András Költő (10831323)

“…Parental support (and its interaction with time) also had a significant but small protective role.</p>Conclusion<p>Despite a small decrease over time, still 4% of participants reported early sexual initiation in 2022. …”

Data Sheet 1_Standardized Rhodiola rosea injection for left ventricular remodeling and inflammation in patients with HFrEF: a systematic review and meta-analysis.docx by Xuqin Du (8803772)

“…</p>Results<p>Twenty-five RCTs with 2,325 participants were included. SRRI significantly improved LVR, indicated by increased LVEF (MD = 6.81, 95% CI: 5.71 to 7.91, P < 0.00001), reduced LVEDD (MD = −4.37, 95% CI: −5.42 to −3.33, P < 0.00001), and decreased LVESD (MD = −4.48, 95% CI: −5.42 to −3.58, P < 0.00001). …”

Table 1_The effects of magnesium and vitamin D/E co-supplementation on inflammation markers and lipid metabolism of obese/overweight population: a systematic review and meta-analys... by Kai Deng (299054)

“…In contrast, the serum levels of interleukin-6 (IL-6) showed a non-significant decrease (MD: −0.09, 95%CI: −0.33, 0.15, p = 0.46), and did not significantly affect lipid metabolism according to levels of parameters such as serum triglyceride (MD = 1.84, 95% CI: −28.92, 32.60, p = 0.91), serum LDL-c (MD: −4.56, 95% CI: −14.19, 5.08, p = 0.35), and serum HDL-c (MD: 1.96, 95% CI: −3.07, 6.98, p = 0.45) in the co-supplementation of magnesium and Vitamin E.…”

Table 1_Exploring the relationship between vitamin B12, methylmalonic acid levels and all-cause mortality in heart failure populations: insights from the NHANES database.docx by Wei Yu (43094)

“…Elevated serum MMA levels were significantly associated with an increased risk of all-cause mortality (Tertile 3 compared with Tertile 1: adjusted HR: 1.52; 95% CI: 1.09, 2.13; p = 0.01), demonstrating a dose–response pattern (26% increased mortality risk per unit increase in lnMMA). …”

Table 2_Exploring the relationship between vitamin B12, methylmalonic acid levels and all-cause mortality in heart failure populations: insights from the NHANES database.docx by Wei Yu (43094)

“…Elevated serum MMA levels were significantly associated with an increased risk of all-cause mortality (Tertile 3 compared with Tertile 1: adjusted HR: 1.52; 95% CI: 1.09, 2.13; p = 0.01), demonstrating a dose–response pattern (26% increased mortality risk per unit increase in lnMMA). …”

Whole 16S rRNA gene sequencing reveals differences in the oral microbiota of healthy individuals infected with oral HPV by Toby I. Maidment (15296219)

“…</p> <p>We demonstrated (1) significant differences in the abundance of <i>Streptococcus salivarius</i> in oral HPV-negative males; (2) males with low-risk HPV had an increased abundance of several species and (3) decreased abundance of <i>Streptococcus salivarius</i> and <i>Streptococcus parasanguinis</i>. …”

Image 1_Insights into the alteration of vaginal microbiota and metabolites in pregnant woman with preterm delivery: prospective cohort study.tif by Lihua Wang (14548)

“…In addition, vaginal metabolomics-based LC-Orbitrap-MS/MS revealed that the contents of 2-Piperidone, Melphalan, N-acetylputrescine, Obatoclax, Eurostoside, Pregnanediol 3-O-glucuronide, O-Phospho-L-serine, 1-Kestose and N-arachidonylglycine were significantly decreased in the PrPG group compared with the PrTG group, while Acenocoumarol, Isopyrazam, Pentosidine, hexose, 7-Hydroxymitragynine, PE, Tamoxifen and 1-Deoxynojirimycin contents were significantly increased. …”

Table 1_Insights into the alteration of vaginal microbiota and metabolites in pregnant woman with preterm delivery: prospective cohort study.docx by Lihua Wang (14548)

“…In addition, vaginal metabolomics-based LC-Orbitrap-MS/MS revealed that the contents of 2-Piperidone, Melphalan, N-acetylputrescine, Obatoclax, Eurostoside, Pregnanediol 3-O-glucuronide, O-Phospho-L-serine, 1-Kestose and N-arachidonylglycine were significantly decreased in the PrPG group compared with the PrTG group, while Acenocoumarol, Isopyrazam, Pentosidine, hexose, 7-Hydroxymitragynine, PE, Tamoxifen and 1-Deoxynojirimycin contents were significantly increased. …”

Supplementary Material for: Real-life nationwide outcomes of bronchoscopic lung volume reduction with endobronchial valves in severe COPD by Borg M. (20443724)

“…Results: Following BLVR, a significant increase in FEV1, similar to the improvements reported in randomized controlled trials was observed. …”

Table 1_Association between higher estimated glucose disposal rate and reduced prevalence of hyperuricemia and gout.docx by Pengfei Liu (136115)

“…Fully adjusted multivariable logistic regression models revealed that for each 1-unit increase in eGDR, the prevalence of HUA decreased by 17% (OR: 0.83, 95% CI: 0.81–0.85, p < 0.001), and the prevalence of gout also decreased by 17% (OR: 0.83, 95% CI: 0.79–0.87, p < 0.001). …”

Data Sheet 1_Short-term structured dietary and exercise interventions delay diabetes onset in prediabetic patients: a prospective quasi-experimental study.pdf by Zhen Wang (72451)

“…Hypothesis<p>Prediabetes indicates an increased risk of developing diabetes mellitus. We hypothesized that structured anti-inflammatory and antioxidant dietary and exercise interventions (SAIDEs) can reduce the onset of diabetes in prediabetic patients.…”

Table2_Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda.xlsx by Phillip Ssekamatte (10217206)

“…</p>Results<p>Naïve CD4⁺ T cells were significantly decreased in the LTBI-DM compared to the LTBI-only participants [0.47 (0.34-0.69) vs 0.91 (0.59-1.05); (p<0.001)]. …”

Table1_Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda.docx by Phillip Ssekamatte (10217206)

“…</p>Results<p>Naïve CD4⁺ T cells were significantly decreased in the LTBI-DM compared to the LTBI-only participants [0.47 (0.34-0.69) vs 0.91 (0.59-1.05); (p<0.001)]. …”

Image1_Impaired Mycobacterium tuberculosis-specific T-cell memory phenotypes and functional profiles among adults with type 2 diabetes mellitus in Uganda.jpeg by Phillip Ssekamatte (10217206)

“…</p>Results<p>Naïve CD4⁺ T cells were significantly decreased in the LTBI-DM compared to the LTBI-only participants [0.47 (0.34-0.69) vs 0.91 (0.59-1.05); (p<0.001)]. …”

Table_1_Predicting cancer-related mycobiome aspects in gastrointestinal cancers: a systematic review.docx by György Szklenarik (20296893)

“…Observing the interindividual variability, we found that the Ascomycota/Basidiomycota (A/B) ratio from healthy to cancer state decreased in n = 2, increased in n = 1 cases, and did not change significantly in n = 2 studies. …”

Data_Sheet_1_Predicting cancer-related mycobiome aspects in gastrointestinal cancers: a systematic review.DOCX by György Szklenarik (20296893)

“…Observing the interindividual variability, we found that the Ascomycota/Basidiomycota (A/B) ratio from healthy to cancer state decreased in n = 2, increased in n = 1 cases, and did not change significantly in n = 2 studies. …”