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significant degs » significant genes (Expand Search), significant adverse (Expand Search), significant cause (Expand Search)
larger decrease » marked decrease (Expand Search)
degs decrease » mean decrease (Expand Search), teer decrease (Expand Search), we decrease (Expand Search)
_ decrease » _ decreased (Expand Search), _ decreasing (Expand Search)
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Data Sheet 1_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx
Published 2025“…</p>Results<p>A total of 897 DEGs were identified, with functional enrichment analysis revealing significant involvement in T cell activation (p=2.84×10<sup>-3</sup>), neuroactive ligand-receptor interaction (p=6.01×10<sup>-4</sup>), and osteoclast differentiation (NES=2.83). …”
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Data Sheet 5_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.csv
Published 2025“…</p>Results<p>A total of 897 DEGs were identified, with functional enrichment analysis revealing significant involvement in T cell activation (p=2.84×10<sup>-3</sup>), neuroactive ligand-receptor interaction (p=6.01×10<sup>-4</sup>), and osteoclast differentiation (NES=2.83). …”
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Supplementary file 1_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.docx
Published 2025“…</p>Results<p>A total of 897 DEGs were identified, with functional enrichment analysis revealing significant involvement in T cell activation (p=2.84×10<sup>-3</sup>), neuroactive ligand-receptor interaction (p=6.01×10<sup>-4</sup>), and osteoclast differentiation (NES=2.83). …”
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Data Sheet 2_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx
Published 2025“…</p>Results<p>A total of 897 DEGs were identified, with functional enrichment analysis revealing significant involvement in T cell activation (p=2.84×10<sup>-3</sup>), neuroactive ligand-receptor interaction (p=6.01×10<sup>-4</sup>), and osteoclast differentiation (NES=2.83). …”
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Data Sheet 3_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx
Published 2025“…</p>Results<p>A total of 897 DEGs were identified, with functional enrichment analysis revealing significant involvement in T cell activation (p=2.84×10<sup>-3</sup>), neuroactive ligand-receptor interaction (p=6.01×10<sup>-4</sup>), and osteoclast differentiation (NES=2.83). …”
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Data Sheet 4_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.xlsx
Published 2025“…</p>Results<p>A total of 897 DEGs were identified, with functional enrichment analysis revealing significant involvement in T cell activation (p=2.84×10<sup>-3</sup>), neuroactive ligand-receptor interaction (p=6.01×10<sup>-4</sup>), and osteoclast differentiation (NES=2.83). …”
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Data Normalization.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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Organize Data.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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PCA.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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Correlation Heatmap.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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Immune Cell Correlation Analysis.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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GO Enrichment Analysis.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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Differential Analysis.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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GO Diagram.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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Hub Genes.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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PPI.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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Download Data.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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Heatmap.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”
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Figure 2.
Published 2025“…The GSE73461 dataset, downloaded from the Gene Expression Omnibus (GEO) database, includes 78 KD patients and 55 normal controls collected by Imperial College London from 2015 to 2023, and was analyzed to identify differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed significant involvement of these DEGs in acute inflammatory responses, plasma membrane components, PI3K-Akt signaling, and cytokine interactions. …”