بدائل البحث:
significantly impair » significantly impairs (توسيع البحث), significantly impaired (توسيع البحث), significantly impact (توسيع البحث)
largest decrease » marked decrease (توسيع البحث)
larger decrease » marked decrease (توسيع البحث)
significantly impair » significantly impairs (توسيع البحث), significantly impaired (توسيع البحث), significantly impact (توسيع البحث)
largest decrease » marked decrease (توسيع البحث)
larger decrease » marked decrease (توسيع البحث)
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1581
Image 2_Differential Ca2+ handling by isolated synaptic and non-synaptic mitochondria: roles of Ca2+ buffering and efflux.tif
منشور في 2025"…Since, non-synaptic mitochondria displayed a significantly reduced ss[Ca<sup>2+</sup>]<sub>e</sub>, this suggested a larger mCa<sup>2+</sup> buffering capacity to maintain [Ca<sup>2+</sup>]<sub>m</sub> with increasing mCa<sup>2+</sup> loads. …"
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1582
Image 3_Differential Ca2+ handling by isolated synaptic and non-synaptic mitochondria: roles of Ca2+ buffering and efflux.tif
منشور في 2025"…Since, non-synaptic mitochondria displayed a significantly reduced ss[Ca<sup>2+</sup>]<sub>e</sub>, this suggested a larger mCa<sup>2+</sup> buffering capacity to maintain [Ca<sup>2+</sup>]<sub>m</sub> with increasing mCa<sup>2+</sup> loads. …"
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1583
Improved estimation of soil organic carbon stock in subtropical cropland of Southern China based on digital soil mapping and multi-sources data
منشور في 2025"…Additionally, the mean value of SOCD significantly decreased from 3.23 in the 1980s to 2.95 kg m<sup>−2</sup> in the 2010s. …"
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1584
Data Sheet 1_Improving tea quality and fruit yield through intercropping with climbing plants.pdf
منشور في 2025"…Tea polyphenol content decreased with increasing density, most notably in PE-H (−21.63% vs. …"
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1585
Dataset.
منشور في 2024"…In the intervention group, there was a significant decrease in the likelihood of violence against the elderly, with a 10-fold reduction. …"
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1586
CONSORT flow diagram.
منشور في 2024"…In the intervention group, there was a significant decrease in the likelihood of violence against the elderly, with a 10-fold reduction. …"
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1587
Figure 5 from Integrated Molecular Characterization of Patient-Derived Models Reveals Therapeutic Strategies for Treating CIC-DUX4 Sarcoma
منشور في 2025"…The repression of MAPK signaling by the CIC-DUX4 fusion protein renders CDSs mainly dependent on the AKT/mTOR pathway. Trabectedin can impair HMGA2 activity by preventing its binding to promoters, thus inhibiting the transcription of its targets <i>IGF2BP2</i> and <i>IGF2BP3</i> and decreasing IGF2/IGF1R signaling. …"
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1588
Presentation 1_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhi...
منشور في 2025"…</p>Results<p>NuGel (0.3% [Nu0.3] and 0.5% [Nu0.5]) was well-tolerated, with no adverse drug reactions or serious adverse events. Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …"
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1589
Presentation 3_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhi...
منشور في 2025"…</p>Results<p>NuGel (0.3% [Nu0.3] and 0.5% [Nu0.5]) was well-tolerated, with no adverse drug reactions or serious adverse events. Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …"
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1590
Data Sheet 1_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhibi...
منشور في 2025"…</p>Results<p>NuGel (0.3% [Nu0.3] and 0.5% [Nu0.5]) was well-tolerated, with no adverse drug reactions or serious adverse events. Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …"
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1591
Data Sheet 2_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhibi...
منشور في 2025"…</p>Results<p>NuGel (0.3% [Nu0.3] and 0.5% [Nu0.5]) was well-tolerated, with no adverse drug reactions or serious adverse events. Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …"
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1592
Presentation 2_A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhi...
منشور في 2025"…</p>Results<p>NuGel (0.3% [Nu0.3] and 0.5% [Nu0.5]) was well-tolerated, with no adverse drug reactions or serious adverse events. Nu0.3 showed a significant decrease in EASI score from baseline (-12.2%, [-30.3%, 5.9%], p = 0.04). …"
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1593
Table 1_Microplastics in focus: a silent disruptor of liver health- a systematic review.docx
منشور في 2025"…., increased serum cysteine, decreased hepatic cysteine, and disturbed homocysteine metabolism), impair mitochondrial bioenergetics, and lead to significant lipid accumulation after exposures lasting up to 500 h. …"
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1594
Ubiquitin degradation of the Ribonuclease H2 subunit B Rnh2B regulates the virulence of <i>Cryptococcus neoformans</i>
منشور في 2025"…Research has shown that the absence of Cdc4, an F-box protein in <i>C. neoformans</i>, decreases virulence, yet the mechanisms by which Cdc4 affects these processes remain unclear. …"
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1595
Supplementary file 2_Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice.docx
منشور في 2025"…Introduction<p>Gossypol impairs reproduction in both sexes, inducing mitochondrial dysfunction, irregular cycles, and fewer ovarian follicles, leading to decreased fertility rates. …"
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1596
Supplementary file 1_Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice.docx
منشور في 2025"…Introduction<p>Gossypol impairs reproduction in both sexes, inducing mitochondrial dysfunction, irregular cycles, and fewer ovarian follicles, leading to decreased fertility rates. …"
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1597
Epidemiological analysis of SARS-CoV-2 variants in Saudi Arabia
منشور في 2025"…The first wave occurred in June 2020, the second wave occurred in July 2021, and the largest wave occurred in January 2022. Our findings also revealed that after vaccination against COVID-19 was introduced, the number of deaths per month significantly decreased. …"
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1598
Table 3_Exploring the effects of dietary methionine supplementation on European seabass mucosal immune responses against Tenacibaculum maritimum.xlsx
منشور في 2025"…These findings, together with the lower mRNA expression of proinflammatory genes in the head kidney and the higher mortality rates observed in this group, suggest a potential impairment of the immune response.`</p>Discussion<p>Overall, these findings indicate that dietary methionine supplementation may significantly influence both systemic and local immune responses in European seabass, highlighting the need for careful consideration when supplementing diets with methionine.…"
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1599
Table 1_Atractylenolide-I restore intestinal barrier function by targeting the S100A9/AMPK/mTOR signaling pathway.xlsx
منشور في 2025"…<p>Impaired intestinal epithelial barrier function is closely associated with the pathogenesis of ulcerative colitis (UC). …"
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1600
Image 2_Atractylenolide-I restore intestinal barrier function by targeting the S100A9/AMPK/mTOR signaling pathway.tif
منشور في 2025"…<p>Impaired intestinal epithelial barrier function is closely associated with the pathogenesis of ulcerative colitis (UC). …"