DataSheet1_Protective effect of baicalin on oxidative stress injury in retinal ganglion cells through the JAK/STAT signaling pathway in vitro and in vivo.PDF حسب Huan Yu (140826)

"…It effectively alleviates oxidative stress and inflammatory responses, reduces cell apoptosis, and improves the pathological changes in the retina of rat models of RGCs damage, thereby decreasing RGCs death. …"

Table 1_The efficacy and safety of danuglipron and orforglipron in patients with type 2 diabetes and obesity: a systematic review and meta-analysis.docx حسب Jingjing Zhou (179820)

"…Meta-analysis results demonstrated that danuglipron significantly decreased HbA1c (mean difference [MD]: −0.90; 95% CI: −1.06, −0.74), FPG (MD: −24.66; 95% CI: −30.45, −18.86) and weight (MD: −2.17; 95% CI: −3.10, −1.23) and improved FPI (MD: 2.94; 95% CI: 1.50, 4.38). …"

pH sensitive lipid polymeric hybrid nanoparticle (LPHNP) of paclitaxel and curcumin for targeted delivery in breast cancer حسب Hrishikesh Sarma (14827761)

"…MTT-assay studies revealed enhanced cytotoxicity of CUR and PTX as LPHNPs showing IC₅₀ value of free CUR & PTX 480.06 µg/mL decreasing to 282.97 µg/mL for CS-CUR-PTX-LPHNPs. <i>In vivo</i> pharmacokinetic evaluations in rats confirmed significantly improved bioavailability, with a 3.8-fold increase in AUC for CUR and a 6.6-fold increase for PTX. …"

Data Sheet 1_The efficacy and safety of danuglipron and orforglipron in patients with type 2 diabetes and obesity: a systematic review and meta-analysis.docx حسب Jingjing Zhou (179820)

"…Meta-analysis results demonstrated that danuglipron significantly decreased HbA1c (mean difference [MD]: −0.90; 95% CI: −1.06, −0.74), FPG (MD: −24.66; 95% CI: −30.45, −18.86) and weight (MD: −2.17; 95% CI: −3.10, −1.23) and improved FPI (MD: 2.94; 95% CI: 1.50, 4.38). …"

Data Sheet 1_Silica nanoparticles alleviate cadmium toxicity to Pisum sativum L. seedling growth by remodeling carbon-nitrogen metabolism.docx حسب Xiaohuan Yang (3697462)

"…Moreover, Cd content in the roots (22.24%) and leaves (67.88%) of pea seedlings decreased with nSiO₂ treatment, improving mineral nutrition and alleviating Cd-induced growth inhibition. …"

Table 1_Effect of mindfulness group therapy on maternal psychological distress and perinatal outcomes in twin pregnancy: a randomized controlled trial.docx حسب Ying Zhou (25031)

"…</p>Results<p>A total of 109 women with twin pregnancies completed the intervention. The intervention significantly and effectively prevented the worsening of postpartum depression symptoms in women with twin pregnancies, improved mindfulness, and reduced perceived stress (P < 0.05). …"

Supplementary file 1_Effectiveness and impact of intravenous magnesium sulfate in spinal surgery systematic review and meta-analysis.docx حسب Zhaoguo Jin (21563024)

"…Magnesium sulfate administration significantly reduced pain scores at 24 h (MD −0.18, 95% CI: −0.34 to −0.02) and decreased opioid consumption (SMD −0.34, 95% CI: −1.07 to −0.35). …"

Table 1_Weissella confusa alleviates experimental colitis in mice by regulating inflammatory pathways and gut microbiota.xlsx حسب Huijing Tang (19133347)

"…</p>Results<p>Compared with DSS group, W. confusa Wc1982 significantly improved the disease phenotypes of colitis mice including decreased DAI and pathological score and reduced colon shortening, decreased colonic IL-17, IL-6, and TNF-α levels and serum lipopolysaccharide (p < 0.05), and downregulated the expression of key genes of IL-17 pathway (Lcn2, Mmp3, Mmp13, Ptgs2; p < 0.05). …"

Supplementary file 1_Weissella confusa alleviates experimental colitis in mice by regulating inflammatory pathways and gut microbiota.docx حسب Huijing Tang (19133347)

"…</p>Results<p>Compared with DSS group, W. confusa Wc1982 significantly improved the disease phenotypes of colitis mice including decreased DAI and pathological score and reduced colon shortening, decreased colonic IL-17, IL-6, and TNF-α levels and serum lipopolysaccharide (p < 0.05), and downregulated the expression of key genes of IL-17 pathway (Lcn2, Mmp3, Mmp13, Ptgs2; p < 0.05). …"

Table 1_Leaf senescence characteristics and economic benefits of rice under alternate wetting and drying irrigation and blended use of polymer-coated and common urea.docx حسب Dongliang Qi (3228141)

"…This suggested that AWD combined with N2 and N3 could delay the leaf senescence of rice, thus achieving a larger grain yield. Moreover, AWD significantly decreased water costs (irrigation amount) and labor costs (irrigation frequency), thus increasing total income. …"

Participants baseline characteristics. حسب Shenghang Wang (21213000)

"…</p><p>Results</p><p>The results showed that MMF exposure significantly improved BMD, bone mineral content (BMC), bone microarchitecture and bone strength in OVX mice. …"

Flowchart of the clinical trial. حسب Shenghang Wang (21213000)

"…</p><p>Results</p><p>The results showed that MMF exposure significantly improved BMD, bone mineral content (BMC), bone microarchitecture and bone strength in OVX mice. …"

Interim Effects of Zoledronate, Denosumab, or Teriparatide on Bone Microarchitecture in Type 2 Diabetes: A Pilot Trial حسب Trupti Nagendra Prasad (17266455)

"…</p><p dir="ltr">Results: Baseline demographic, biochemical, aBMD and HR-pQCT parameters were comparable across groups. Teriparatide significantly improved total and trabecular vBMD (tibia/radius), trabecular number (Tb.N), BV/TV (tibia), and trabecular thickness (radius). …"

Supplementary Material for: Hemispherotomy for Drug-Resistant Epilepsy in a Low-resource Setting: Surgical Outcomes and Quality of Life in 23 Children Treated in a Hybrid Program i... حسب figshare admin karger (2628495)

"…At last follow-up, the majority of children were seizure-free, and all children had decreased seizure frequency. Families reported improved cognitive function, improved QoL and high satisfaction with their decision to pursue this surgery.…"

Interim Effects of Zoledronate, Denosumab, or Teriparatide on Bone Microarchitecture in Type 2 Diabetes: A Pilot Trial حسب Trupti Nagendra Prasad (17266455)

"…</p><p dir="ltr">Results: Baseline demographic, biochemical, aBMD and HR-pQCT parameters were comparable across groups. Teriparatide significantly improved total and trabecular vBMD (tibia/radius), trabecular number (Tb.N), BV/TV (tibia), and trabecular thickness (radius). …"

Image 1_Innate immune pathway activation to modulate mesenchymal stromal cell (MSC) interactions with synovium and cartilage.jpeg حسب Peter Linde (22011383)

"…STING-MSC-CM decreased IL-6, IL-8 secretion (p = 0.08) by synoviocytes, decreased IL-8 (p = 0.05) by activated chondrocytes, increased G-CSF (p = 0.01), IL-4 (p = 0.01) and decreased IL-5 (p = 0.01) by activated macrophages. …"

Data Sheet 1_BAM8-22 targets spinal MrgC receptors to modulate UPRmt activity in the mechanism of bone cancer pain.docx حسب Mingming Xie (20963636)

"…</p>Results<p>Mice with bone cancer pain showed improved mRNA and protein levels of UPR^mt-related molecules, increased MMP and ATP, decreased mitochondrial ROS levels in the spinal cord after receiving an intrathecal injection of BAM8-22. …"

Image 1_The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells.tif حسب Jianguo Zhang (6482)

"…E2F1 was identified as an upstream regulator of EIF4EBP1, with knockdown of E2F1 significantly decreasing EIF4EBP1 promoter activity and binding. …"

Long-term impact of molecular epidemiology shifts of methicillin-resistant <i>Staphylococcus aureus</i> on severity and mortality of bloodstream infection حسب Norihito Kaku (7439288)

"…Over this 16-year period, SCC<i>mec</i> type II decreased significantly from 79.2% to 15.5%, while type IV increased from 18.2% to 65.5%. …"

Data Sheet 1_Physical activity of moderate-intensity optimizes myocardial citrate cycle in a murine model of heart failure.pdf حسب Lucyna Widacha (20981330)

"…Interestingly, 8-sWR significantly decreased myocardial citrate content in the presence of unchanged myocardial [BCAAs], ETC proteins content and mtDNA copy number.…"