Table 1_Case Report: Generalized anxiety disorder and hypertension: a bidirectional loop unraveled by integrated management.docx by Junming Chen (3603422)

“…Multimodal management combining pharmacotherapy (escitalopram, tandospirone), transcranial magnetic stimulation (9 sessions), biofeedback (14 sessions), psychotherapy, and lifestyle interventions achieve: mean BP decreased significantly from 176/105 mmHg to 125/72 mmHg during hospitalization; significant anxiety reduction (HAMA = 3), mean BP stabilized at 131/77 mmHg with 50% reduction in antihypertensive dosages, normalization of elevated ACTH (99.9→normal pg/mL) and cortisol (18.7→normal μg/dL) and sustained improvement at 6-month follow-up.…”

Table 1_Inoculation frequency and maize genotype influence plant growth-promoting effects of soil bacteria under low nitrogen conditions.xlsx by Lexie R. Foster (22235653)

“…In addition, our results showed a significant growth response to repeated inoculations with a beneficial bacterial isolate. …”

Table 5_Inoculation frequency and maize genotype influence plant growth-promoting effects of soil bacteria under low nitrogen conditions.xlsx by Lexie R. Foster (22235653)

“…In addition, our results showed a significant growth response to repeated inoculations with a beneficial bacterial isolate. …”

Data Sheet 1_Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review.docx by Yiyi Feng (12530035)

“…</p>Results<p>The meta-analysis revealed that LUT significantly ameliorated colon length, reduced the disease activity index, alleviated body weight loss, and decreased histological scores. …”

Data Sheet 1_Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective T... by Xinxin Ying (21507500)

“…Survival analysis revealed a significant correlation between elevated TIM-3 expression and decreased patient survival. …”

Table 3_Analysis of global trends in acute lymphoblastic leukemia in children aged 0–5 years from 1990 to 2021.docx by Fang Ding (222713)

“…</p>Findings<p>Between 1990 and 2021, the global number of childhood ALL cases increased by 59.06%, reaching 168,879 cases in 2021, while ALL-related deaths and DALYs decreased by 66.71% and 66.13%, respectively. High- and high-middle SDI regions demonstrated significant improvements, driven by advances in healthcare and early diagnosis. …”

Table 1_Detailed understanding of reduced geoeffectiveness of solar cycle 24 in association with geomagnetic storms.xlsx by R. Selvakumaran (21290378)

“…<p>Solar Cycle 24, the weakest in over a century, exhibited significant deviations from previous cycles, beginning with a prolonged minimum, weak polar fields, and asynchronous polar field reversal, leading to hemispheric asymmetry. …”

Table 2_Inoculation frequency and maize genotype influence plant growth-promoting effects of soil bacteria under low nitrogen conditions.xlsx by Lexie R. Foster (22235653)

“…In addition, our results showed a significant growth response to repeated inoculations with a beneficial bacterial isolate. …”

Data Sheet 1_Remarkable tumor response to Iruplinalkib in a 14-year-old girl with ALK-positive advanced metastatic non–small-cell lung cancer: a case report.pdf by Jiahao Wang (4710915)

“…Most metastatic lesions also showed significant regression. By six months, the pulmonary tumor had almost disappeared. …”

Supplemental data for "<b>Kidney cell response to acute cardiorenal and isolated kidney ischemia-reperfusion injury</b>" in Physiological Genomics by Kevin Burfeind (20421194)

“…In each dataset, we found that proximal tubule (PT) cells of the kidney undergo significant gene expression changes, with decreased expression of genes critically important for cell identity and function, indicative of dedifferentiation. …”

Image 1_Global, regional, and national epidemiology of congenital heart disease in children from 1990 to 2021.tif by Jiaoli Xu (20871584)

“…Background<p>Congenital heart disease (CHD) is a leading cause of morbidity and mortality in children globally, with significant variations in outcomes across different regions.…”

Image 1_A case report: enhanced somatostatin receptor expression in metastatic pancreatic neuroendocrine tumor following everolimus therapy.pdf by Pei Zhang (232846)

“…However, therapeutic options become limited once SSTR expression decreases. This case report describes a 55-year-old man with grade 2 pNET who developed multiple liver metastases after undergoing pancreaticoduodenectomy in 2015. …”

Data Sheet 1_Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study.docx by Heinz Wiendl (237353)

“…Changes in genes and pathways associated with innate and adaptive immune response were observed after CladT treatment, along with reductions in pro-inflammatory cytokine-producing B and T cells and increases in anti-inflammatory cytokine-producing T cells. IgG and IgM levels remained above the lower limits of normal in most participants. sNfL levels decreased, remaining reduced by M24. …”

Data Sheet 2_Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study.csv by Heinz Wiendl (237353)

“…Changes in genes and pathways associated with innate and adaptive immune response were observed after CladT treatment, along with reductions in pro-inflammatory cytokine-producing B and T cells and increases in anti-inflammatory cytokine-producing T cells. IgG and IgM levels remained above the lower limits of normal in most participants. sNfL levels decreased, remaining reduced by M24. …”

All data. by Ke Li (106849)

“…Metabolomics analysis revealed that inulin treatment significantly modulated the levels of 8 stage-specific metabolites; notably, it increased anti-inflammatory, anti-diabetic and neuroprotective metabolites taurine and dodecanoic acid in prediabetic mice, while decreasing pro-inflammatory mediators including oleamide and adrenic acid. …”

Data Sheet 1_Premature renal epithelial cell senescence promoted by LXN/Rps3/p53 signaling pathway activation increases calcium oxalate crystal deposition by altering macrophage po... by Maolin Chu (11611507)

“…Furthermore, reducing cellular LXN/Rps3/p53 signaling significantly decreased SASP factors in the culture medium and simultaneously abolished M1-like phenotype macrophage polarization. …”

Data Sheet 2_Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation.xlsx by Wenyong Liao (21669332)

“…In goiter rats, 16S rRNA sequencing revealed eight differentially abundant microbial taxa including significantly reduced B. bifidum, accompanied by: (1) impairment of two butyrate synthesis pathways, (2) decreased levels of six SCFAs (including butyrate), (3) impaired thyroid iodine uptake, (4) downregulated NIS expression, and (5) thyroid dysfunction [reduced triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4) with elevated thyroid-stimulating hormone (TSH)] - all measurements showing statistical significance (p < 0.05).…”

Data Sheet 1_Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation.xls by Wenyong Liao (21669332)

“…In goiter rats, 16S rRNA sequencing revealed eight differentially abundant microbial taxa including significantly reduced B. bifidum, accompanied by: (1) impairment of two butyrate synthesis pathways, (2) decreased levels of six SCFAs (including butyrate), (3) impaired thyroid iodine uptake, (4) downregulated NIS expression, and (5) thyroid dysfunction [reduced triiodothyronine (T3), thyroxine (T4), free T3 (FT3), free T4 (FT4) with elevated thyroid-stimulating hormone (TSH)] - all measurements showing statistical significance (p < 0.05).…”

Preliminary efficacy of eye movement desensitization and reprocessing for children aged 1.5–8 years with PTSD: a multiple baseline experimental design (<i>N</i> = 19) by Carlijn de Roos (8061239)

“…</p><p>The findings also show a significant reduction in emotional and behavioural problems as well as parenting stress.…”

Data Sheet 1_Effectiveness of community-based management models in chronic obstructive pulmonary disease: a systematic review and meta-analysis.docx by Miao Zhan (2625718)

“…Telemedicine management also significantly reduced the frequency of acute exacerbations of COPD (MD = −0 0.56; 95% CI [−0.79, −0.32], p < 0.00001). …”