Showing 1,801 - 1,820 results of 16,674 for search '(( significantly ((level decrease) OR (mean decrease)) ) OR ( significantly increased decrease ))', query time: 0.69s Refine Results
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    Downregulation of TRIM37 expression exacerbates pathological damage in the MS model. by Lai Jiang (2401513)

    Published 2025
    “…<b>(d, e)</b> ROS detection (n = 3) indicated a significant increase in intracellular oxidative stress levels in the model group compared to the control group. …”
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    Overexpression <i>TRIM37</i> promotes myelin repair and inhibits cell apoptosis by upregulating PEX5. by Lai Jiang (2401513)

    Published 2025
    “…<p><b>(a, b)</b> Western blot (n = 3) showed a significant increase in PEX5 protein levels in the OE-TRIM37 group compared to the LPC group. …”
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    Primer sequences and information. by Lai Jiang (2401513)

    Published 2025
    “…Through bioinformatics analysis, TRIM37 was found to be significantly downregulated in MS patients. <i><i>In vitro</i></i> experiments demonstrated that overexpression <i>TRIM37</i> could stabilize PEX5 protein via non-degradative monoubiquitination, thereby maintaining peroxisomal metabolic function, reducing oxidative stress levels, significantly decreasing apoptosis in both oligodendrocytes and neurons, and promoting the expression of myelin basic protein (MBP). …”
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