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    Including non-sigmoidal melting curves in peptide-level TPP-TR datasets largely increases the number of discoveries. by Cecile Le Sueur (19751667)

    Published 2024
    “…(A) Considering non-conventional melting curves in the analysis makes it possible to include almost twice (1.78) as many phospho-peptides compared to the published melting point (<i>T</i><sub><i>m</i></sub>) analysis. (B) By increasing the phospho-peptides coverage, GPMelt captures about five times more (4.9) mono-phosphorylated peptides than the published <i>T</i><sub><i>m</i></sub> analysis, and captures phosphosites associated with significantly higher functional scores than non-captured phosphosites (one-sided Wilcoxon signed-rank test). …”
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