Table 1_Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis.docx by Rui Jiang (264894)

“…Introduction<p>Rheumatoid arthritis (RA) is an autoimmune disorder characterized by significant disability and teratogenic effects, for which there are few effective curative therapies. …”

Main module structure. by Dunlu Lu (19964225)

“…At the same time, the model size was reduced by 9.3%, and the number of model layers was decreased, reducing computational costs and storage requirements. …”

Data Sheet 5_CD44 knockdown alters miRNA expression and their target genes in colon cancer.zip by Diana Maltseva (11678641)

“…Introduction<p>Metastasis formation poses a significant challenge to oncologists, as it severely limits the survival of colorectal cancer (CRC) patients. …”

Supplementary Material for: Efficacy of penetrating canaloplasty versus trabeculectomy in patients with bilateral primary glaucoma: a self-control study by figshare admin karger (2628495)

“…Although not statistically significant, higher qualified success was observed in TRAB (96.0%) than in PCP group (88.0%, p=0.609) at 12 month. …”

DataSheet1_Associations of serum folate and vitamin B12 levels with all-cause mortality among patients with metabolic dysfunction associated steatotic liver disease: a prospective... by Jiaxin Zhu (446571)

“…When their serum concentrations were below the median level, the risk of all-cause mortality decreased with increasing concentration, reaching a lowest risk around the median level, and then leveled off. …”

Image 2_Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer... by Chase Garcia (21803576)

“…</p>Results<p>At this concentration, BHB significantly and concentration-dependently decreased the following: 1) inflammatory cytokine expression (IL-6, TNF-α, and IL-1β), 2) inflammatory morphological changes, and 3) activation of p-ERK and p-p38MAPK, which are key pathways involved in microglial inflammation. …”

Table 1_Blue and red LEDs modulate polyphenol production in Precoce and Tardiva cultivars of Cichorium intybus L..docx by Felicia Menicucci (7495508)

“…The polyphenolic composition of the two cultivars significantly changed depending on the type of LEDs used. …”

Table 3_Antifungal mechanism and transcriptome analysis of Bacillomycin D-C16 against Fusarium oxysporum.xlsx by Fuxing Lin (7418234)

“…Furthermore, nearly all DEGs related to DNA replication were significantly suppressed. Biochemical assays confirmed these observations: Reduced activities of mitochondrial enzymes [malate dehydrogenase (MDH), isocitrate dehydrogenase (IDH), pyruvate dehydrogenase (PDH), and complexes I–V], decreased mitochondrial membrane potential, and diminished ATP content collectively indicated mitochondrial dysfunction. …”

Table 7_Identification and validation for biomarkers associated with mitochondrial metabolism in chronic obstructive pulmonary disease.xlsx by Wenjun Wang (314231)

“…The mRNA and protein expression of APRT and LCAT were significantly decreased in COPD patients’ lung tissues.…”

Table 1_An alternative structured weight management protocol to rapid weight loss in mixed martial arts: a prospective interventional study of pre-competition weight management str... by Clóvis Albuquerque Maurício (22389121)

“…Starting 7 days before the weigh-in, athletes consumed 7 liters of fluids per day, with intake gradually decreasing. On the day before the weigh-in, they consumed only 0.5 liters. …”

Supplementary file 1_Forced intensity-controlled endurance training on a small-animal treadmill machine inducing murine cardiac hypertrophy: insights and comparison to voluntary ru... by Maximillian Fischer (14758063)

“…<p>Endurance training is associated with decreased cardiovascular-related morbidity and mortality. …”

Image 3_Club cell-derived brain-derived neurotrophic factor regulates murine airway mechanics and mucin production in response to IL-13 in a sex-dependent manner.jpeg by Amy Fagan (17678004)

“…No statistically significant differences were observed in pulmonary mechanics between male mice with or without conditional loss of epithelial cell Bdnf, although treatment effects of IL-13 were noted. …”

Dependent and independent variables (N = 316). by Priyanka Saluja (20501044)

“…<div><p>Introduction</p><p>Unmet oral health needs remain a significant issue among immigrant adolescents, often exacerbated by experiences of racial discrimination. …”

Image 1_Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer... by Chase Garcia (21803576)

“…</p>Results<p>At this concentration, BHB significantly and concentration-dependently decreased the following: 1) inflammatory cytokine expression (IL-6, TNF-α, and IL-1β), 2) inflammatory morphological changes, and 3) activation of p-ERK and p-p38MAPK, which are key pathways involved in microglial inflammation. …”

DataSheet2_Mechanism of Valeriana officinalis L. extract improving atherosclerosis by regulating PGC-1α/Sirt3/Epac1 pathway.pdf by Bo Yao (308010)

“…Furthermore, the drug significantly increased the mRNA and protein expression of PGC-1α and Sirt3 in aortic tissue, while decreasing the mRNA and protein expression of Epac1, Caspase-3, and Caspase-9.…”

Supplementary file 1_Emergency department overcrowding: first Swiss application of the Emergency Department Work Index and risk factors for overcrowding.pdf by Aline Herzog (22589720)

“…Introduction<p>Emergency department (ED) overcrowding is associated with increased waiting time, reduced patient satisfaction, and decreased quality of care. Numerous validated scores are available for assessing ED overcrowding. …”

Table 2_Global burden and future trends of gastric cancer in women of reproductive age: estimates from the GBD 2021 Study, 1990–2050.xlsx by Nan Jiang (21252)

“…Although incidence is higher in men, GC remains a significant health issue for women of reproductive age (15–49 years) due to biological, hormonal, and socioeconomic factors. …”

Image 1_Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly.png by Vivian Schultz (17379235)

“…No covariates significantly influenced this association (p > 0.05).…”

Table 2_Multi-omics identification and validation of oxidative phosphorylation–related hub genes in schizophrenia.docx by Yu Zhou (89766)

“…Extending these findings in vivo, MK-801–treated mice exhibited behavioral and neuronal deficits, reduced ATP5A fluorescence intensity, and decreased ATP concentrations; expression of all four hub genes was significantly altered, with three (MALAT1, PPIL3, and ITM2A) concordant with transcriptomic results. …”

Data Sheet 1_Increased circulating levels of SP-D and IL-10 are associated with the development of disease severity and pulmonary fibrosis in patients with COVID-19.pdf by Xin Pan (3712768)

“…Among the biomarkers indicative of macrophage polarization, compared to non-ARDS patients, a significant increase in IL-10, Inducible nitric oxide synthase (iNOS), and Arginase-1 (Arg-1) were observed in ARDS patients, while Tumor necrosis factor-α (TNF-α) was decreased. …”