Data Sheet 7_Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.zip حسب Ziqin Wei (19433134)

"…Objective<p>Previous research has demonstrated that the hypoxic environment at high altitudes significantly alters the pharmacokinetics of many drugs, reducing their efficacy and increasing adverse effects. …"

HK2 regulates mRNA translation in melanoma cells. حسب Ana Luisa Dian (22258504)

"…HK2 depletion significantly decreased the abundance of <i>SOX10</i>, <i>CDH2</i>, and <i>WNT5A</i> mRNAs extracted from polysome fractions, but not in total RNAs. …"

Data Sheet 1_α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT–FOXO1–CD36 pathway.pdf حسب Xue Bai (129175)

"…</p>Results<p>In HG/F-induced H9C2 cells, A-MG (1 and 3 μM) significantly increased cell viability (p < 0.01) and reduced LDH release (p < 0.05). …"

SEAwise Report on improved predictive models of recruitment under different habitat scenarios and incorporating experimental results حسب Paco Melià (162862)

"…Recruitment of Western Baltic cod and herring showed decreasing reproductive potential as temperature increased.…"

Data Sheet 1_Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats.pdf حسب Yaoyao Zhu (3487937)

"…Background<p>Age-related ovarian dysfunction, characterized by declining follicular reserve and hormonal imbalance, poses a significant challenge in reproductive endocrinology, severely compromising fertility and quality of life. …"

Water bridges حسب Raman Jangra (19231711)

"…Further, our study emphasizes the functional significance of water-mediated interactions in RNA–protein complexes, and paving the way for exploring how these interactions operate in complex biological environments. …"

Data Sheet 1_The role of oxidative stress in modulating mortality risk across the hypertension control cascade.docx حسب Weihao Liu (4472227)

"…Sensitivity analyses confirmed Nutrition-OBS reduced all-cause mortality by 31%, and Lifestyle-OBS decreased cardiovascular mortality by 45%. RCS analyses verified the inverse OBS-mortality relationship, with mediation analysis revealing partial mediation through low-grade systemic inflammation and multi-organ function.…"

Data Sheet 1_The longitudinal associations between filial piety belief and mobile phone addiction: from the perspective of self-determination theory.zip حسب Hua Wei (60877)

"…The results showed that reciprocal filial piety belief has a negative impact on mobile phone addiction, while authoritarian filial piety belief has no significant effect on mobile phone addiction. In addition, reciprocal filial piety belief influences mobile phone addiction through the mediating effect of basic needs satisfaction. …"

Table 1_Aerobic exercise ameliorates atherosclerosis-induced cognitive impairment via hippocampal IL-33/NF-κB signaling modulation.xlsx حسب Jianwei Peng (811819)

"…Furthermore, aerobic exercise reduces M1 microglial activation and pro-inflammatory cytokines like IL-6, TNF-α, and IL-1β in the hippocampus of AS mice, thereby decreasing neuroinflammation. In summary, aerobic exercise can effectively improve cognitive function by decreasing IL-33 expression and inhibiting NF-κB activation, which in turn reduces microglial activation and the release of inflammatory mediators in the hippocampus. …"

Data Sheet 1_Aerobic exercise ameliorates atherosclerosis-induced cognitive impairment via hippocampal IL-33/NF-κB signaling modulation.xlsx حسب Jianwei Peng (811819)

"…Furthermore, aerobic exercise reduces M1 microglial activation and pro-inflammatory cytokines like IL-6, TNF-α, and IL-1β in the hippocampus of AS mice, thereby decreasing neuroinflammation. In summary, aerobic exercise can effectively improve cognitive function by decreasing IL-33 expression and inhibiting NF-κB activation, which in turn reduces microglial activation and the release of inflammatory mediators in the hippocampus. …"

DataSheet1_Effects of fertilization on litter decomposition dynamics and nutrient release in orchard systems.docx حسب Huayue Nie (20385747)

"…Although adding nutrients decreased soil enzyme activity later in the decomposition process, no significant correlation was detected between enzyme activity and the remaining mass. …"

Table 2_Revealing fitness and virulence determinants of hypervirulent Klebsiella pneumoniae during infection in Galleria mellonella using a transposon library.xlsx حسب Lisheng Xiao (15919517)

"…Going beyond the general knowledge that hypermucoviscosity (HMV) mediates high virulence, we observed that deficits in ptsI and GM2628 led to HMV while decreasing virulence. …"

Table 1_Revealing fitness and virulence determinants of hypervirulent Klebsiella pneumoniae during infection in Galleria mellonella using a transposon library.xlsx حسب Lisheng Xiao (15919517)

"…Going beyond the general knowledge that hypermucoviscosity (HMV) mediates high virulence, we observed that deficits in ptsI and GM2628 led to HMV while decreasing virulence. …"

Data Sheet 1_Revealing fitness and virulence determinants of hypervirulent Klebsiella pneumoniae during infection in Galleria mellonella using a transposon library.pdf حسب Lisheng Xiao (15919517)

"…Going beyond the general knowledge that hypermucoviscosity (HMV) mediates high virulence, we observed that deficits in ptsI and GM2628 led to HMV while decreasing virulence. …"

Modulation of renal inflammation and tubular injury by calcitriol in patients with early diabetic kidney disease: a randomized controlled trial حسب Pringgodigdo Nugroho (15460802)

"…Although UACR decreased more in the calcitriol group, the difference was not statistically significant (<i>p</i> = 0.099). …"

Data Sheet 1_Targeting the leptin receptor promotes MDA-MB-231 cells’ metabolic reprogramming and malignancy: the role of extracellular vesicles derived from obese adipose tissue.d... حسب Carol Costa Encarnação (21412730)

"…Introduction<p>Leptin, a key adipokine secreted by adipose tissue (AT), has emerged as a critical mediator linking obesity and breast cancer, both of which are major global health concerns. …"

Table 1_The impact of IL-17A inhibitors on scalp and gut microbiota in psoriasis.docx حسب Wenxia Huang (12290795)

"…Regarding gut microbiota, significant differences in α-diversity richness were observed compared to healthy controls (P<0.05). …"

<b>Role of the Chaperone ClpB in</b><b> </b><b>Mycoplasma bovis</b><b> Virulence: Implications for </b><b>stress response, a</b><b>dhesion, </b><b>b</b><b>iofilm </b><b>d</b><b>eve... حسب Hui zhang (22187170)

"…Phenotypic characterization revealed that ClpB disruption attenuated key virulence attributes, including: impaired host cell adhesion capacity, significant reduction in biofilm formation (p<0.01), diminished induction of proinflammatory cytokines (IL-1β, IL-6, TNF-α) in infected BoMac cells, decreased extracellular nuclease activity. …"

Data Sheet 2_Predicting mortality in heart failure: BUN/creatinine ratio in MIMIC-III.docx حسب Changsen Zhu (20821991)

"…</p>Conclusions<p>Admission BCR values are non-linearly associated with mortality in heart failure patients, suggesting its utility as a prognostic tool in critical care.…"

Data Sheet 1_Predicting mortality in heart failure: BUN/creatinine ratio in MIMIC-III.csv حسب Changsen Zhu (20821991)

"…</p>Conclusions<p>Admission BCR values are non-linearly associated with mortality in heart failure patients, suggesting its utility as a prognostic tool in critical care.…"