HSP47 inhibitor Col003 may attenuates neurological impairment in chronic ischemic stroke rats by inhibiting LCN2 حسب Kejian Zhou (22557101)

"…</p> <p>Fourteen days post-MCAO, Col003 treatment significantly decreased cerebral infarct volume and enhanced neurological function scores in rats. …"

Data_Sheet_1_Association of Body Roundness Index and A Body Shape Index with Obstructive Sleep Apnea: insights from NHANES 2015–2018 data.docx حسب Xue Pan (680146)

"…Below this threshold, OSA risk increased with higher BRI; however, no significant association was found above this threshold. …"

Table 1_Synergistic effects of multi-enzyme supplementation on nutrient digestion and absorption in the foregut and hindgut.docx حسب Fangyuan Chen (2147119)

"…The results showed that MCPC supplementation significantly upregulated the expression of solute carrier family 17 member 4 (SLC17A4) and vitamin D receptor (VDR) genes in the duodenum (p < 0.05), while downregulating the expression of Calbindin-D28k (CaBP-D28K) and solute carrier family 1 member 4 (SLC1A4) genes (p < 0.05) in growing pigs. …"

Hippocampal volume changes along the rostrocaudal axis in the COUP-TFI mutant mice. حسب Ching-San Tseng (6252566)

"…<p><b>(A)</b> 3D whole brain imaging of Thy1-YFP expression in the adult control cortex. …"

Table 1_Guiren Runchang granules alleviate slow transit constipation in mice by modulating gut microbiota and short-chain fatty acids.docx حسب Xinfeng Bai (5049932)

"…Specifically, the relative abundance of the genera Alloprevotella and Muribaculum increased, while that of Prevotellaceae_NK3B31_group, Ruminococcus, and Lachnospiraceae_UCG-001 decreased. These microbiota changes were significantly correlated with SCFAs level, motility-related hormone concentrations, and defecation phenotype. …"

Image 4_Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer... حسب Chase Garcia (21803576)

"…We focused on 1.5 mM BHB, which reflects blood levels in mice and humans on a KD.</p>Results<p>At this concentration, BHB significantly and concentration-dependently decreased the following: 1) inflammatory cytokine expression (IL-6, TNF-α, and IL-1β), 2) inflammatory morphological changes, and 3) activation of p-ERK and p-p38MAPK, which are key pathways involved in microglial inflammation. …"

Image 2_Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer... حسب Chase Garcia (21803576)

"…We focused on 1.5 mM BHB, which reflects blood levels in mice and humans on a KD.</p>Results<p>At this concentration, BHB significantly and concentration-dependently decreased the following: 1) inflammatory cytokine expression (IL-6, TNF-α, and IL-1β), 2) inflammatory morphological changes, and 3) activation of p-ERK and p-p38MAPK, which are key pathways involved in microglial inflammation. …"

Image 1_Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer... حسب Chase Garcia (21803576)

"…We focused on 1.5 mM BHB, which reflects blood levels in mice and humans on a KD.</p>Results<p>At this concentration, BHB significantly and concentration-dependently decreased the following: 1) inflammatory cytokine expression (IL-6, TNF-α, and IL-1β), 2) inflammatory morphological changes, and 3) activation of p-ERK and p-p38MAPK, which are key pathways involved in microglial inflammation. …"

Image 3_Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer... حسب Chase Garcia (21803576)

"…We focused on 1.5 mM BHB, which reflects blood levels in mice and humans on a KD.</p>Results<p>At this concentration, BHB significantly and concentration-dependently decreased the following: 1) inflammatory cytokine expression (IL-6, TNF-α, and IL-1β), 2) inflammatory morphological changes, and 3) activation of p-ERK and p-p38MAPK, which are key pathways involved in microglial inflammation. …"

Data Sheet 1_Integrated physiological, transcriptomic, and metabolomic analyses of Chrysanthemum ‘Boju’ under excessive indole-3-acetic acid stress.pdf حسب Yuqing Wang (110531)

"…Exogenous IAA treatment also led to a significant reduction in endogenous hormone levels, including gibberellins (GA₃ and GA₄), abscisic acid (ABA), and IAA, with decreases of 93%, 45%, 99%, and 99%, respectively.Transcriptomic and metabolomic analyses identified 263 differentially expressed metabolites and 144 differentially expressed genes.…"

Supplementary file 1_Global burden of HIV, syphilis, and HBV infection among women of childbearing age and children under five: based on the Global Burden of Diseases Study 2021.do... حسب Jia Lian (9469818)

"…</p>Conclusion<p>In 2021, the global disease burden of HIV, syphilis, and HBV infection remained high among WCBA and children under five, with significant regional and demographic disparities. These findings indicate a persistent public health challenge, necessitating continued global efforts to mitigate the burden through addressing socioeconomic inequalities, strengthening health education, and expanding healthcare access.…"

Table_1_Independent and joint influence of depression and advanced lung cancer inflammation index on mortality among individuals with chronic kidney disease.DOCX حسب Jie Zhou (28945)

"…</p>Conclusion<p>In a nationally representative sample of US patients with CKD, coexisting depression and poorer nutrition-inflammation were associated with a significantly increased risk of all-cause mortality.…"

Coconut shell activated carbon (CSAC) reinforced municipal sludge by high pressurized electro-dewatering with constant voltage gradient حسب Binqi Rao (22300677)

"…The results indicated that under a constant voltage gradient of 36 V/cm, the moisture content (<i>M_c</i>) of sludge significantly decreased from 88% to 64%, and there was a noticeable improvement in the resistance and temperature of sludge cake compared to the constant voltage mode. …"

Fig. 2 Suppression of miRNA-21-5p ameliorates ovarian pathological alterations, hormonal imbalance, and insulin resistance in PCOS-IR rats. حسب 陈 晓红 (22613498)

"…<p dir="ltr">(A a-d) Hematoxylin and eosin (H&E) staining showed that miRNA-21-5p downregulation improved ovarian morphology in PCOS-IR rats, reducing cystic follicles and restoring granulosa cell layers (scale bar = 250 μm). …"

Table 1_Effects of sex but not race and geographic origin on vaccine-induced HIV-specific antibody responses.xlsx حسب Wilbert Mbuya (9455160)

"…</p>Results<p>Four weeks post-final vaccination boost, we observed that Envelope-specific antibody titers were significantly increased for IgG1 but reduced for IgA in females (female vs. male median titer: 900 vs. 300, p=0.030 and <100 vs. 100, p=0.007, respectively). …"

Supplementary file 1_Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults.docx حسب Ming Jiang (11433)

"…Restricted cubic spline analysis indicated a positive dose–response relationship between PBDE153 levels and psoriasis risk (P-overall = 0.012, P-nonlinear = 0.881), with a significant linear trend (p < 0.001). Weighted Quantile Sum (WQS) analysis revealed a statistically significant positive association between the BFR mixture and psoriasis risk (OR = 1.709, 95% CI: 1.241–2.370, p = 0.001). …"

Image 2_Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults.tif حسب Ming Jiang (11433)

"…Restricted cubic spline analysis indicated a positive dose–response relationship between PBDE153 levels and psoriasis risk (P-overall = 0.012, P-nonlinear = 0.881), with a significant linear trend (p < 0.001). Weighted Quantile Sum (WQS) analysis revealed a statistically significant positive association between the BFR mixture and psoriasis risk (OR = 1.709, 95% CI: 1.241–2.370, p = 0.001). …"

Data Sheet 1_The triglyceride–glucose index is a promising predictor for the risk of cardiovascular disease in the diabetic population aged ≥60 years in the United States: a retros... حسب Shu Yang (381226)

"…Univariate and multivariate regression analysis models were obtained to explore the association between baseline TyG index and the risk of CVD. Non-linear association were investigated using restricted cubic spline (RCS) regression. …"

Image 1_Inflammation mediation of the association between brominated flame retardants and psoriasis among U.S. adults.tif حسب Ming Jiang (11433)

"…Restricted cubic spline analysis indicated a positive dose–response relationship between PBDE153 levels and psoriasis risk (P-overall = 0.012, P-nonlinear = 0.881), with a significant linear trend (p < 0.001). Weighted Quantile Sum (WQS) analysis revealed a statistically significant positive association between the BFR mixture and psoriasis risk (OR = 1.709, 95% CI: 1.241–2.370, p = 0.001). …"

Maternal diabetes and cardiac left ventricular structure and function in the infant:a Copenhagen Baby Heart Study حسب Jonas Ghouse (5494898)

"…<p dir="ltr">Objective: Prenatal exposure to maternal diabetes is associated with increased risk of offspring heart defects. We evaluated associations with subtle infant cardiac changes.…"