Image 6_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... by Chao Song (379006)

“…</p>Results<p>Three RCTs (IMpower150, jRCT2080224500, and ORIENT-31) comprising a total of 1529 patients were analyzed. The PIBC regimen significantly improved PFS (hazard ratio [HR]: 0.76 [0.66, 0.87], P < 0.0001), objective response rate (risk ratio [RR]: 1.36 [1.22, 1.51], P < 0.00001), and disease control rate (RR: 1.06 [1.00, 1.12], P = 0.04). …”

<b>Efficacy of </b><b>GLP-1-based Therapies on</b><b> </b><b>Metabolic Dysfunction-Associated Steatotic</b><b> Liver Disease and </b><b>Metabolic Dysfunction-Associated</b><b> Stea... by Yahao Wang (21291242)

“…Overall, GLP-1RAs treatment for a median of 24 weeks demonstrated a significant reduction in LFC by 5.21%, with the retatrutide displaying the most obvious treatment effects. …”

Statistical analysis of the AUC measurement. by Esra Ayan (21156015)

“…The mean AUC decreased in both samples.</p> <p>(TIF)</p>…”

<b>Distributed Hydraulic Micro-Cooling (MHD): A Low-Cost, High-Impact Urban Heat Mitigation Strategy</b> / <b>Enfriamiento Hidráulico Micro-Distribuido (MHD): Estrategia Urbana de... by Ricardo Riveros (22484566)

“…Large thermal masses such as roofs, asphalt roads, and concrete structures store significant amounts of solar radiation during the day (up to 1200–1600 MJ/m²). …”

Data Sheet 1_Integrated computational and experimental identification of N-[(1H-1,2,4-triazol-3-yl)phenyl]-1-(1H-pyrazolo[3,4-b]pyridin-3-yl)methanamide as a potent and selective T... by Xinxin Ying (21507500)

“…Survival analysis revealed a significant correlation between elevated TIM-3 expression and decreased patient survival. …”

Raw data for ASV analysis. by Fittree Hayeeawaema (20775941)

“…Treatment with live and heat-killed Ln.m significantly reduced BUN and creatinine levels in CKD mice (<i>p</i> < 0.01 and <i>p</i> < 0.05). …”

Raw data. by Fittree Hayeeawaema (20775941)

“…Treatment with live and heat-killed Ln.m significantly reduced BUN and creatinine levels in CKD mice (<i>p</i> < 0.01 and <i>p</i> < 0.05). …”

Timeline for study enrollment. by Saeun Park (20410160)

“…</p><p>Conclusions</p><p>Negative COVID-19 experiences were significantly associated with more severe depression and anxiety in Ugandan caregivers, regardless of their children’s malaria status. …”

Dataset used in the manuscript. by Saeun Park (20410160)

“…</p><p>Conclusions</p><p>Negative COVID-19 experiences were significantly associated with more severe depression and anxiety in Ugandan caregivers, regardless of their children’s malaria status. …”

mRNA levels of CASP family markers (A-E), BCL2 family markers (F-H) and other apoptosis-related markers (I-M) in limbal stromal cells (LSCs) and in Aniridia-LSCs (AN-LSCs), after t... by Shanhe Liu (5251313)

“…In LSCs, <i>BCL2</i> mRNA level significantly decreased (p = 0.0102) and <i>CDKN1B</i> level significantly increased using 75 µM CoCl₂ treatment. …”

Investigating the Impact of Base Pair Mismatches on Cas13d Cleavage Efficiency Using Molecular Dynamics Simulations by Ye Liu (296340)

“…However, the presence of mismatches significantly undermines the cleavage efficiency of Cas13d to target RNA. …”

Individual Conditional Expectation (ICE) plot showing the predicted probability of BMI across age, sex and self-awareness. by Probir Kumar Ghosh (6947282)

<b>Role of the Chaperone ClpB in</b><b> </b><b>Mycoplasma bovis</b><b> Virulence: Implications for </b><b>stress response, a</b><b>dhesion, </b><b>b</b><b>iofilm </b><b>d</b><b>eve... by Hui zhang (22187170)

“…Phenotypic characterization revealed that ClpB disruption attenuated key virulence attributes, including: impaired host cell adhesion capacity, significant reduction in biofilm formation (p<0.01), diminished induction of proinflammatory cytokines (IL-1β, IL-6, TNF-α) in infected BoMac cells, decreased extracellular nuclease activity. …”

<b>Selective Reduction of Ca</b>^{<strong>2+</strong>}<b>-Independent Phospholipase A</b>_{<strong>2</strong>}<b>b</b><b> (iPLA</b>_{<strong>2</strong>}<b>b... by Abdulaziz Almutairi (9584768)

“…These outcomes are associated with a significant reduction in T1D. Further, inhibition of select proinflammatory lipid signaling pathways reduces M1-like MF polarization and adoptive transfer of M2-like MF reduces NOD T1D incidence, suggesting a mechanism by which iDLs impact T1D development. …”

Data from paper: <i> Twenty-year effect of sewage-sludge fertilization in a Mediterranean </i><i>grassland: Impact on species composition, functional groups and interrelation with... by Mercedes Valerio (22631942)

“…Fertilization also influenced the interannual response of the community to autumn temperature, June and summer drought differently depending on the species functional group and traits; herbaceous perennials with higher Leaf Dry Matter Content and lower leaf area decreased with summer drought, while the influence of summer drought in annuals and woody perennials was reduced. …”

Additional file 2 of Gut Microbiome dysbiosis and immune activation correlate with somatic and neuropsychiatric symptoms in COVID-19 patients by Paula L. Scalzo (20882386)

“…Conversely, (i) Albumin levels decrease with increasing severity, with significant reductions in the critical group compared to low and moderate groups. …”

Data Sheet 1_Intelligent pressure-controlled percutaneous unroofing: advancing minimally invasive renal cyst treatment.pdf by Haijun Liao (13851617)

“…Additionally, patients in the IPC-PURC group reported lower postoperative pain scores (p < 0.001). No significant differences were observed between the two groups in terms of hemoglobin decrease or complication rates. …”

Supplementary Material for: Forecasting the Worldwide Impact of Stroke for individuals aged 45 and above by Fan W. (11417327)

“…Age estimates show that older age groups, particularly those aged 75 to 79, are at higher risk of stroke. In addition, there is a significant inverse relationship between SDI and stroke severity, with areas with higher SDI tending to have lower morbidity, mortality, and DALYs. …”

Supplementary Material for: Collagen I Derived Extracellular Matrix Motifs Alter Fibroblast Regenerative Response by figshare admin karger (2628495)

“…Results mEMCs had reduced intensity in collagen I associated bands, indicating successful fragmentation to lower molecular weights. Soluble free mECMs induced changes in fibroblast phenotype as indicated by a decrease in proliferation, decrease in nuclei area, and increase in percentage of elongated cells. …”

Data_Sheet_1_Distribution characteristics of soil active organic carbon at different elevations and its effects on microbial communities in southeast Tibet.PDF by Fanglin Ran (19931256)

“…The Shannon diversity of bacteria exhibited a significant decrease with increasing altitude, whereas no significant change was observed in the diversity of fungi. …”