DataSheet1_Updated evidence of the Naoshuantong capsule against ischemic stroke: a systematic review and meta-analysis of randomized controlled trials.docx by Cuilin Que (19743256)

“…Background<p>Stroke is a serious health issue that can result in death or disability, leading to a significant economic strain on society and families. …”

Data Sheet 1_The oncometabolite R-2-hydroxyglutarate inhibits microglial activation via the FTO/NF-κB pathway.docx by Lu Wang (45927)

“…While R-2HG is known to impair CD8+ T-cell function, its specific impact on microglial activation remains unknown. …”

Table 3_Multi-omics reveals that NOTCH1 promotes cervical cancer progression and reduces radiosensitivity.xlsx by Aihua Guo (13267712)

“…Cell communication analysis indicated that malignant cells with high NOTCH1 expression might lead to impaired plasma cell differentiation due to the impairment of the MIF ligand-receptor pathway. …”

Table 1_Multi-omics reveals that NOTCH1 promotes cervical cancer progression and reduces radiosensitivity.docx by Aihua Guo (13267712)

“…Cell communication analysis indicated that malignant cells with high NOTCH1 expression might lead to impaired plasma cell differentiation due to the impairment of the MIF ligand-receptor pathway. …”

Table 2_Multi-omics reveals that NOTCH1 promotes cervical cancer progression and reduces radiosensitivity.docx by Aihua Guo (13267712)

“…Cell communication analysis indicated that malignant cells with high NOTCH1 expression might lead to impaired plasma cell differentiation due to the impairment of the MIF ligand-receptor pathway. …”

Data Sheet 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.xlsx by Demos Kynigopoulos (12420457)

“…</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …”

Table 1_Case report: Treatment of severe phorate poisoning.xlsx by Wang Kunlun (21287522)

“…Phoratoxon sulfoxide has the highest concentration of these metabolites, followed by phoratoxon sulfone, phorate sulfone, phorate sulfoxide, and phoratoxon, respectively. HP treatment significantly lowered the serum levels of the toxic metabolites terminology. …”

Supplementary Material for: Supportive care for common conditions in small vulnerable newborns and term infants: the evidence by Jiang L. (4145290)

“…Kangaroo mother care (KMC) significantly reduced SVN’s mortality by discharge. Early erythropoiesis stimulating agent lowered SVN’s risk of receiving blood transfusion. …”

Supplementary file 1_Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease.docx by Demos Kynigopoulos (12420457)

“…</p>Methods<p>We investigated the effects of two FDA-approved metabolic agents—Alirocumab, a PCSK9 inhibitor that lowers LDL cholesterol, and Gliclazide, a sulfonylurea that enhances insulin secretion—in male 5xFAD mice, a transgenic model of AD. …”

The quality metrics of 4C-seq data. by Tingting Jiang (169999)

“…Functional assays demonstrated that targeted repression of Pparα-En4 region significantly decreased <i><i>Ppar</i>α</i> expression and impaired brown adipocyte differentiation and thermogenesis. …”

<i>Edwardsiella piscicida</i> employs C3 derivative to mediate internalization and infection via the teleost-specific receptor by Mo-Fei Li (21624535)

“…When PoCD18 was knocked down or blocked, bacterial infection and tissue lesions were significantly decreased. Mechanistically, the intracellular domain of PoCD18 subsequently interacted with PoCytohesin and triggered the phosphorylation of the phosphatidylinositol 3-kinase (PI3K)/serine-threonine protein kinase (Akt) signalling pathway. …”

Data Sheet 3_The power of GM-CSF: immune regulation in the defense against Phialophora verrucosa infection.pdf by Qi Dong (119569)

“…</p>Results<p>Compared to WT mice, GM-CSF deficiency significantly delayed fungal clearance and prolonged disease progression, accompanied by reduced inflammatory responses and decreased neutrophil infiltration. …”

Supplementary file 3_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.jpeg by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Supplementary file 4_Intracerebroventricular calycosin attenuates cerebral ischemia-reperfusion injury in rats via HMGB1-dependent pyroptosis inhibition.docx by Yuhui Zhang (399617)

“…</p>Results and Discussion<p>Calycosin significantly reduced neurological impairments and brain infarction in a dose-dependent manner, alleviated neuronal damage and decreased the expression of pyroptosis-related markers, including NLRP3, GSDMD, HMGB1, IL-1β, IL-18, and caspase-1. …”

Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis by Yuechu Zhao (20481846)

“…Ferroptosis-related proteins were significantly increased post-MI in Apelin^−/− mice whereas p-AMPK was greatly decreased. …”

Table 2_Epidemiological trends and disparities in iodine, vitamin A, and iron deficiencies among children aged 0–14 years globally, 1990–2021.docx by Fang Peng (327071)

“…Vitamin A deficiency incidence rate decreased by 94.9% (EAPC: −2.02), while DALY rates fell 92.8%. …”

Data Sheet 1_The power of GM-CSF: immune regulation in the defense against Phialophora verrucosa infection.pdf by Qi Dong (119569)

“…</p>Results<p>Compared to WT mice, GM-CSF deficiency significantly delayed fungal clearance and prolonged disease progression, accompanied by reduced inflammatory responses and decreased neutrophil infiltration. …”

Data Sheet 1_Confronting the anxiety of Generation Z: electroacupuncture therapy regulates oxidative stress and microglia activity in amygdala-basolateral of socially isolated mice... by Tong Yin (3576917)

“…Introduction<p>Anxiety disorders are prevalent mental health conditions characterized by significant impairments in daily functioning and social interactions. …”

Table 1_Exploring the role of LOX family in glioma progression and immune modulation.docx by Chen Liu (75209)

“…LOX expression correlated with increased infiltration of macrophages and eosinophils and decreased presence of Treg and CD8+ T cells. Knockdown of LOX genes impaired glioma cell functions, induced apoptosis, and altered immune cell behavior by reducing M2 macrophage polarization and enhancing CD8+ T cell activity.…”

Supplementary Materials -Table by Shaojie Zhang (20807333)

“…In the present study, we discovered that hypobaric hypoxia exposure not only reduced the number of colonic goblet cells in mice by 27.6% but also impaired their mucus secretion. Transcriptome sequencing analysis of sorted goblet cells from the mice colon revealed significant changes in gene expression profiles, particularly in the expression of canonical goblet cell markers such as calcium-activated chloride channel regulator 1 (Clca1) and Fcγ-binding protein (Fcgbp). …”