Data Sheet 1_The CD38+HLA-DR+ T cells with activation and exhaustion characteristics as predictors of severity and mortality in COVID-19 patients.docx by Qiuyue Long (11381148)

“…</p>Results<p>We revealed a significant increase in CD38⁺HLA-DR⁺ T cells in non-survivor COVID-19 patients, establishing them as an independent risk factor for 28-day mortality. …”

Supplementary Material for: The efficacy of hemoperfusion in severe COVID-19 patients: A systematic review and meta-analysis by figshare admin karger (2628495)

“…After hemoperfusion, the P/F ratio (WMD 95.79[74.46, 117.12]mmHg; p < 0.05; I2 = 5.8%) increased, while CRP (WMD -44.03[-68.97, -19.09]mg/L; p < 0.05; I2 = 86.9%) decreased.…”

Table 1_Global, regional, and national anemia burden among women of reproductive age (15–49 years) from 1990 to 2021: an analysis of the Global Burden of Disease Study 2021.docx by Wenshuai Zheng (21641225)

“…Background<p>Anemia remains a significant global health challenge, disproportionately affecting women of reproductive age (WRA, 15 to 49 years) due to physiological and socioeconomic factors. …”

Table1_Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and coloca... by Jingshuang Song (11340138)

“…</p>Results<p>Gene-predicted levels of ten proteins were associated with breast cancer risk. Decreased levels of CASP8, DDX58, CPNE1, ULK3, PARK7, and BTN2A1, as well as increased levels of TNFRSF9, TNXB, DNPH1, and TLR1, were linked to an elevated risk of breast cancer. …”

DataSheet1_Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and co... by Jingshuang Song (11340138)

“…</p>Results<p>Gene-predicted levels of ten proteins were associated with breast cancer risk. Decreased levels of CASP8, DDX58, CPNE1, ULK3, PARK7, and BTN2A1, as well as increased levels of TNFRSF9, TNXB, DNPH1, and TLR1, were linked to an elevated risk of breast cancer. …”

Image 2_Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activa... by Jiaochen Luan (9704384)

“…Multi-omics analysis revealed significant enrichment in lipid metabolic pathways, with Fasn identified as a hub gene. …”

Image2_Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway.TIF by Sisi Lei (10999575)

“…</p>Results<p>The MS-related IR model exhibited a decreased p-Akt/Akt ratio and increased fasting glucose, insulin, homeostatic model assessment of IR, and hepatic lipid metabolism factors. …”

Supplementary file 1_Comparative effects of high-intensity interval training versus moderate-intensity continuous training on body composition and blood pressure in overweight adol... by Xilin Li (1913320)

“…Background and aims<p>Adolescent overweight and obesity are increasing worldwide, posing a growing public health concern. …”

Data Sheet 1_Microbial dysbiosis in obstructive sleep apnea: a systematic review and meta-analysis.docx by Yang Guo (399435)

“…Furthermore, in comparison to the non-OSA individuals, the gut environment of patients with OSA exhibited an increased relative abundance of phylum Firmicutes, along with elevated levels of genera Lachnospira; conversely, there was a decreased relative abundance of phylum Bacteroidetes and genus Ruminococcus and Faecalibacterium. …”

Table2_Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway.XLSX by Sisi Lei (10999575)

“…</p>Results<p>The MS-related IR model exhibited a decreased p-Akt/Akt ratio and increased fasting glucose, insulin, homeostatic model assessment of IR, and hepatic lipid metabolism factors. …”

Table 1_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…</p>Results<p>Globally, the incidence of pediatric IE declined by 27.6% (95% UI, −30.9% to −24.9%) and mortality by 21.4% (95% UI, −35.2% to −0.8%) between 1990 and 2021, with an estimated annual percentage change (EAPC) of −1.37% (95% CI, −1.49% to −1.24%) and −0.64% (95% CI, −0.75% to −0.54%), respectively. DALYs decreased by 19.2% (95% UI, −33.2% to 1.9%). Marked disparities persisted, with high-SDI regions, notably China, achieving the greatest reductions in burden, while sub-Saharan Africa and Eastern Europe exhibited stagnant or increasing rates. …”

Image1_Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway.TIF by Sisi Lei (10999575)

“…</p>Results<p>The MS-related IR model exhibited a decreased p-Akt/Akt ratio and increased fasting glucose, insulin, homeostatic model assessment of IR, and hepatic lipid metabolism factors. …”

Table 3_The global burden of pediatric infective endocarditis (5–14 years): epidemiological patterns from 1990 to 2021 and projected trajectories.pdf by Ying Xiao (6517)

“…</p>Results<p>Globally, the incidence of pediatric IE declined by 27.6% (95% UI, −30.9% to −24.9%) and mortality by 21.4% (95% UI, −35.2% to −0.8%) between 1990 and 2021, with an estimated annual percentage change (EAPC) of −1.37% (95% CI, −1.49% to −1.24%) and −0.64% (95% CI, −0.75% to −0.54%), respectively. DALYs decreased by 19.2% (95% UI, −33.2% to 1.9%). Marked disparities persisted, with high-SDI regions, notably China, achieving the greatest reductions in burden, while sub-Saharan Africa and Eastern Europe exhibited stagnant or increasing rates. …”

DataSheet2_Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and co... by Jingshuang Song (11340138)

“…</p>Results<p>Gene-predicted levels of ten proteins were associated with breast cancer risk. Decreased levels of CASP8, DDX58, CPNE1, ULK3, PARK7, and BTN2A1, as well as increased levels of TNFRSF9, TNXB, DNPH1, and TLR1, were linked to an elevated risk of breast cancer. …”

Data Sheet 1_Reconstructing Holocene centennial cooling events: synthesized temperature changes, chronology, and forcing in the Northern Hemisphere.docx by Sergey A. Gorbarenko (13696381)

“…The Holocene Thermal Maximum (HTM) happened between HCCEs 5 and 4a and was interrupted by HCCE 4c and 4b, coeval, with a significant southward shift of the ITCZ, likely related to cooling in the tropical zone. …”

Supplementary Material for: Genetical predicted causal relationship between gut microbiota and different types of kidney diseases by figshare admin karger (2628495)

“…Butyricicoccus, Catenibacterium, Flavonifractor, and Lachnospira were associated with an increased risk of membranous nephropathy, while RuminococcaceaeUCG011 was associated with a decreased risk of membranous nephropathy. …”

Table 4_Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activa... by Jiaochen Luan (9704384)

“…Multi-omics analysis revealed significant enrichment in lipid metabolic pathways, with Fasn identified as a hub gene. …”

Image 1_Association between controlling nutritional status score and mortality in older patients with dysphagia in Japan: a retrospective cohort study.tif by Yan Wang (15435)

“…Median survival durations decreased progressively: 716 days (mild), 362 days (moderate), and 106 days (severe). …”

Image 3_Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activa... by Jiaochen Luan (9704384)

“…Multi-omics analysis revealed significant enrichment in lipid metabolic pathways, with Fasn identified as a hub gene. …”

Table1_Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin resistance in metabolic syndrome by regulating the LXRα/SREBP-1 signaling pathway.XLSX by Sisi Lei (10999575)

“…</p>Results<p>The MS-related IR model exhibited a decreased p-Akt/Akt ratio and increased fasting glucose, insulin, homeostatic model assessment of IR, and hepatic lipid metabolism factors. …”