Cell-targeted transgenic control of 5HT_2AR levels in neurons and glia during the experience-dependent critical period. by Vanessa Kay Miller (19775496)

“…Two-way ANOVA with Tukey’s multiple comparison shows EB experience-dependent increase in 5HT_2A receptor levels in both transgenic controls (<i>n</i> = 10 each, <i>repo-</i>Gal4<i>; p</i> = 5.38 × 10⁻¹⁰, <i>elav</i>-Gal4; <i>p</i> = 0.0205), a significant decrease in 5HT_2A receptor levels in both RNAi conditions (<i>n</i> = 10 each, <i>repo-</i>Gal4<i>; p</i> = 4.63 × 10⁻¹⁰, <i>elav-</i>Gal4; <i>p</i> = 1.05 × 10⁻⁹), and a significant elevated EB response with glial <i>5HT</i>_<i>2A</i><i>R</i> OE (<i>n</i> = 10/condition, <i>p</i> = 2.36 × 10⁻⁹). …”

Data Sheet 1_Temperature extremes across elevation gradients: evidence from two German mountain observatories.pdf by Monica Ionita (6486275)

“…Temperature extremes have also changed markedly: cold extremes have declined significantly at both locations (e.g., the duration of cold spells has decreased by 16 days at Hohenpeißenberg and by 10 days at Zugspitze, over the period 1981–2024), while warm extremes exhibit a pronounced rise, especially in the Warm Spell Duration Index (WSDI), which has nearly doubled since the 1980s. …”

Data Sheet 1_Mechanisms of c-Fos regulation of mTOR signaling via ERα/β in abnormal lipid metabolism of granulosa cells in PCOS.pdf by Xinyi Chen (491760)

“…In PCOS patients, c-Fos and p-mTOR/mTOR protein levels were higher than in male factor infertility patients, while ERα levels were lower, with no significant difference in ERβ expression between the two groups. …”

Image 2_NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.tiff by M. Firoz Mian (10013314)

“…However, DMPA significantly decreased the total number of VT CD4+ and CD8+ T cells and the number of IFN-γ producing CD4 and CD8 T cells and increased the percentage of CD4 and CD8 T cells producing TNF-α compared to untreated mice. …”

Image 3_NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.tiff by M. Firoz Mian (10013314)

“…However, DMPA significantly decreased the total number of VT CD4+ and CD8+ T cells and the number of IFN-γ producing CD4 and CD8 T cells and increased the percentage of CD4 and CD8 T cells producing TNF-α compared to untreated mice. …”

Image 5_NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.tiff by M. Firoz Mian (10013314)

“…However, DMPA significantly decreased the total number of VT CD4+ and CD8+ T cells and the number of IFN-γ producing CD4 and CD8 T cells and increased the percentage of CD4 and CD8 T cells producing TNF-α compared to untreated mice. …”

Image 4_NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.tiff by M. Firoz Mian (10013314)

“…However, DMPA significantly decreased the total number of VT CD4+ and CD8+ T cells and the number of IFN-γ producing CD4 and CD8 T cells and increased the percentage of CD4 and CD8 T cells producing TNF-α compared to untreated mice. …”

Image 1_NET-EN treatment leads to delayed HSV-2 infection, enhanced mucin and T cell functions in the female genital tract when compared to DMPA in a preclinical mouse model.tiff by M. Firoz Mian (10013314)

“…However, DMPA significantly decreased the total number of VT CD4+ and CD8+ T cells and the number of IFN-γ producing CD4 and CD8 T cells and increased the percentage of CD4 and CD8 T cells producing TNF-α compared to untreated mice. …”

Supplementary Material for: Impact of robotic surgery on postoperative pancreatic fistula for high-risk pancreaticojejunostomy after pancreatoduodenectomy by Fuji T. (13875467)

“…These results suggest that RPD may be significantly associated with a decreased incidence of CR-POPF in high-risk anastomoses.…”

AjMLKL is involved in 10⁸ CFU/mL AJ01 induced lytic coelomocyte death independent on its phosphorylation. by Kaiyu Chen (11691918)

“…Coelomocyte viability was significantly increased (L), and coelomocytes plasma membrane disruption (M) and the percentage of Annexin V+/PI+ coelomocytes significantly decreased (N). …”

Related to Fig 3. by Mohammad Nafees Ansari (22232505)

“…(<b>O</b>, <b>P</b>) Cell proliferation assay confirms an increase in cell proliferation of BT-474_ZFX^OE cells (mean ± SEM, <i>n</i> = 5) (O), whereas BT-474_ZFX^SL cells (mean ± SEM, <i>n</i> = 3) show decreased cell proliferation (P). (<b>Q</b>) Tumor growth kinetics recorded a significantly higher growth of BT-474_ZFX^OE (mean ± SEM, <i>n</i> = 5) than BT-474_VECT^OE tumors. …”

Data Sheet 1_Lung microbiome alterations correlate with immune imbalance in non-small cell lung cancer.docx by Jiuling Cheng (16890546)

“…Furthermore, patients with higher abundance of Prevotella and Veillonella exhibited a significantly elevated systemic immune-inflammation index (SII) compared to the lower-abundance group (P = 0.0329), while their CD8⁺ T cell levels were significantly decreased in the higher abundance group (P = 0.0027).…”

Data Sheet 1_Increased vegetation disturbance intensity reduces soil nutrients while enhancing microbial network interactions.pdf by Boya Gao (8840498)

“…Bacterial abundance under moderate and extreme disturbances was significantly lower than that in the control, whereas fungal abundance was significantly higher under extreme disturbance. …”

Data Sheet 2_Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy.docx by Wenjun Li (41954)

“…The levels of pro-inflammatory cytokines in blood were also significantly decreased in shPD-L1 treated mice. Additionally, T cell apoptosis rates in the spleen showed a 2-fold increase in treated mice. …”

Data Sheet 1_Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy.pdf by Wenjun Li (41954)

“…The levels of pro-inflammatory cytokines in blood were also significantly decreased in shPD-L1 treated mice. Additionally, T cell apoptosis rates in the spleen showed a 2-fold increase in treated mice. …”

Analyzing the global burden of 11 subtypes of congenital birth defects: trends, sociodemographic correlates, and outcomes from 1990 to 2021 by Enhui Yang (11844002)

“…The findings advocate for enhanced prevention and management strategies specifically designed for regions with lower SDIs.</p> <p></p><p>The prevalence, mortality, and DALYs attributable to congenital birth defects (CBDs) significantly decreased globally from 1990 to 2021, though notable regional disparities persist.…”

Image 3_Low CD46 expression on activated CD4+ T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donor... by Julie Stichova (19729855)

“…The calcitriol-induced regulatory effect manifested by a stronger surface decrease of CD46 on activated CD4⁺ T cells (by 40% in HDs and by 26% in AEA), accompanied by a significant inhibition of IFN-γ and increased IL-10 production (by 31% in HDs and by 85% in AEA). …”

Image 1_Low CD46 expression on activated CD4+ T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donor... by Julie Stichova (19729855)

“…The calcitriol-induced regulatory effect manifested by a stronger surface decrease of CD46 on activated CD4⁺ T cells (by 40% in HDs and by 26% in AEA), accompanied by a significant inhibition of IFN-γ and increased IL-10 production (by 31% in HDs and by 85% in AEA). …”

Image 4_Low CD46 expression on activated CD4+ T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donor... by Julie Stichova (19729855)

“…The calcitriol-induced regulatory effect manifested by a stronger surface decrease of CD46 on activated CD4⁺ T cells (by 40% in HDs and by 26% in AEA), accompanied by a significant inhibition of IFN-γ and increased IL-10 production (by 31% in HDs and by 85% in AEA). …”

Image 2_Low CD46 expression on activated CD4+ T cells predict improved Th1 cell reactivity to calcitriol in majority of patients with allergic eosinophilic asthma and healthy donor... by Julie Stichova (19729855)

“…The calcitriol-induced regulatory effect manifested by a stronger surface decrease of CD46 on activated CD4⁺ T cells (by 40% in HDs and by 26% in AEA), accompanied by a significant inhibition of IFN-γ and increased IL-10 production (by 31% in HDs and by 85% in AEA). …”