Data Sheet 1_Global, regional, and national burden of pneumococcal disease among children and adolescents aged <20 years from 1990 to 2021: a predictive analysis.docx by Gan-min Wang (21188933)

“…Background<p>Pneumococcal infections remain a leading cause of preventable deaths among children and adolescents aged <20 years. Despite a global decrease in burden, significant regional and socioeconomic disparities, as well as long-term trends, are not fully understood.…”

Image_1_High-fat diet mouse model receiving L-glucose supplementations propagates liver injury.JPEG by Johnny Amer (495285)

“…D- and L-Glu supplementations showed significant decrease of Glycogenesis (low GYS2/PYGL ratio) and unchanged p-AKT pattern compared to their RD counterparts.…”

Table4_Efficacy and safety of guanxinshutong capsule combined with western medicine on stable angina pectoris: a systematic review and meta-analysis.DOC by Liyuan Yu (5341841)

“…GXST and WM combination was significantly more effective than WM alone across several metrics: clinical efficacy rate (odds ratio [OR] = 4.05, 95% confidence interval [CI] = 3.42–4.80), electrocardiogram improvement (OR = 3.39, 95% CI = 2.35–4.87), enhancement in left ventricular ejection fraction (mean difference [MD] = 1.07, 95% CI = 0.69–1.46), reduction in total cholesterol levels (MD = −0.78, 95% CI = −1.20 to −0.35), decrease in tumor necrosis factor-alpha (MD = −1.36, 95% CI = −2.18 to −0.53), and improvement in Chinese medicine evidence score (OR = 3.77, 95% CI = 2.20–6.43). …”

JAK/STAT signaling can activate MMP expression. by Bente Winkler (20760273)

“…In pupal stages, <i>Mmp2</i> expression decreases significantly upon <i>STAT92E</i> downregulation and reaches control levels. …”

Image1_Efficacy and safety of guanxinshutong capsule combined with western medicine on stable angina pectoris: a systematic review and meta-analysis.JPEG by Liyuan Yu (5341841)

“…GXST and WM combination was significantly more effective than WM alone across several metrics: clinical efficacy rate (odds ratio [OR] = 4.05, 95% confidence interval [CI] = 3.42–4.80), electrocardiogram improvement (OR = 3.39, 95% CI = 2.35–4.87), enhancement in left ventricular ejection fraction (mean difference [MD] = 1.07, 95% CI = 0.69–1.46), reduction in total cholesterol levels (MD = −0.78, 95% CI = −1.20 to −0.35), decrease in tumor necrosis factor-alpha (MD = −1.36, 95% CI = −2.18 to −0.53), and improvement in Chinese medicine evidence score (OR = 3.77, 95% CI = 2.20–6.43). …”

Table_1_Trends and predictions of maternal sepsis and other maternal infections among women of childbearing age: a systematic analysis for the global burden of disease study 2019.X... by Hang Qian (444740)

“…From 1990 to 2019, the estimated global age-standardized incidence and mortality rates of MSMIs (AAPC: -1.32, 95% CI: −1.34 to −1.30; AAPC: -3.39, 95% CI: −4.28 to −2.48) in WCBA both demonstrated significant declining trends. The changing trends varied significantly across 6 regions and 204 countries. …”

Image_1_High-fat diet mouse model receiving L-glucose supplementations propagates liver injury.JPEG by Johnny Amer (495285)

“…D- and L-Glu supplementations showed significant decrease of Glycogenesis (low GYS2/PYGL ratio) and unchanged p-AKT pattern compared to their RD counterparts.…”

Supplementary file 2_Wuzi-Yanzong-Wan inhibits testicular mitochondrial apoptosis in rats by downregulating TAp73-Mediated P38 MAPK-ADAM17 pathway.docx by Ziao Liu (8938748)

“…Mechanistic investigations revealed that WZYZW markedly suppressed germ cell apoptosis (flow cytometry confirmed a significant decrease in apoptotic cell proportion) and attenuated DNA damage (indicated by significantly reduced γ-H2AX (a DNA damage marker) fluorescence intensity). …”

Table3_Efficacy and safety of guanxinshutong capsule combined with western medicine on stable angina pectoris: a systematic review and meta-analysis.DOC by Liyuan Yu (5341841)

“…GXST and WM combination was significantly more effective than WM alone across several metrics: clinical efficacy rate (odds ratio [OR] = 4.05, 95% confidence interval [CI] = 3.42–4.80), electrocardiogram improvement (OR = 3.39, 95% CI = 2.35–4.87), enhancement in left ventricular ejection fraction (mean difference [MD] = 1.07, 95% CI = 0.69–1.46), reduction in total cholesterol levels (MD = −0.78, 95% CI = −1.20 to −0.35), decrease in tumor necrosis factor-alpha (MD = −1.36, 95% CI = −2.18 to −0.53), and improvement in Chinese medicine evidence score (OR = 3.77, 95% CI = 2.20–6.43). …”

Table 3_Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis.docx by Tainã Luís de Souza (21574790)

“…A notable finding was the decrease in the CD68⁺NOS2⁺/CD68⁺Arginase-1⁺ ratio in animals with higher parasite load. …”

Table1_Microbe-immune interactions: new perspectives on coagulation deficiencies, purpura, and other hemorrhagic conditions under the regulation of the gut microbiota.xlsx by Ruhua Ren (19815546)

“…The mediating effect is opposite to the overall trend and has a relatively small impact. No significant heterogeneity or pleiotropy was observed.…”

Data Sheet 1_TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury.zip by Yunsheng Zhang (474242)

“…Background<p>Traumatic brain injury (TBI) triggers a cascade of neuroinflammatory responses mediated by microglial activation, which significantly contributes to secondary brain damage. …”

Table2_Microbe-immune interactions: new perspectives on coagulation deficiencies, purpura, and other hemorrhagic conditions under the regulation of the gut microbiota.docx by Ruhua Ren (19815546)

“…The mediating effect is opposite to the overall trend and has a relatively small impact. No significant heterogeneity or pleiotropy was observed.…”

Image 5_The global burden of neonatal sepsis attributable to air pollution from 1990 to 2021: findings from the global burden of disease study 2021.jpeg by Jiajia Duan (9351878)

“…</p>Conclusion<p>Overall, air pollution remains a significant public health challenge threatening neonatal health. …”

Table_3_Effectiveness of written emotional disclosure interventions for eating disorders: a systematic review and meta-analysis.pdf by Yufei Wang (171069)

“…The written emotional disclosure intervention can decrease eating disorder symptoms scores (SMD = −0.20, 95% CI [−0.34, −0.05], Z = 2.59, p = 0.01), body dissatisfaction scores (SMD = 0.37, 95% CI [0.21, 0.52], Z = 4.59, p < 0.001), and thin ideal internalization score (SMD = 0.42, 95% CI [0.22, 0.62], Z = 4.12, p < 0.001). …”

Image_4_Trends and predictions of maternal sepsis and other maternal infections among women of childbearing age: a systematic analysis for the global burden of disease study 2019.J... by Hang Qian (444740)

“…From 1990 to 2019, the estimated global age-standardized incidence and mortality rates of MSMIs (AAPC: -1.32, 95% CI: −1.34 to −1.30; AAPC: -3.39, 95% CI: −4.28 to −2.48) in WCBA both demonstrated significant declining trends. The changing trends varied significantly across 6 regions and 204 countries. …”

Table 1_Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis.docx by Tainã Luís de Souza (21574790)

“…A notable finding was the decrease in the CD68⁺NOS2⁺/CD68⁺Arginase-1⁺ ratio in animals with higher parasite load. …”

Data Sheet 1_Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction.pdf by Leonardo Elias Sternkopf (22308115)

“…Apoptotic signaling was predominantly mediated by a dynamic remodeling of caspase 9 pathway, accompanied by a significant loss of mitochondrial potential and a sharp decrease in Bid and Bcl2 transcription, favoring the intrinsic over the FasL-dependent extrinsic pathway and mechanisms. …”

Dataset: Foraminiferal denitrification and deep bioirrigation influence benthic biogeochemical cycling in a seasonally hypoxic fjord by Subhadeep Rakshit (19702714)

“…</p><p dir="ltr">Abstract of the paper: </p><p dir="ltr">Benthic macro- and micro-biota often play significant roles in controlling the biogeochemical dynamics in sediments. …”

Supplementary file 1_Multi-omics exploration of chaperone-mediated immune-proteostasis crosstalk in vascular dementia and identification of diagnostic biomarkers.docx by Wentong Li (492392)

“…Single-cell resolution analysis showed HSP90AA1 to be specifically overexpressed in oligodendrocytes (72.23%), significantly correlating with glial depletion (4.56% decrease in oligodendrocytes, p<0.01) and aberrant neuronal proliferation (144.23% increase, p=0.0032). …”